Mycosis fungoides—like lesions associated with phenytoin and carbamazepine therapy

Rijlaarsdam, Udo; Scheffer, E.; Meijer, Chris J.L.M.; Kruyswijk, M.R.J.; Willemze, Rein

doi:10.1016/0190-9622(91)70029-2

Cited by 80 publications

(34 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…41,46,47 Drug-induced pseudolymphoma may be remarkably similar to MF with a dense, bandlike, lymphoid infiltrate in the superficial dermis; mild lymphocyte enlargement and atypia; and intraepidermal lymphocytes (Figure 4, C through H). 40,41,44 Pautrier microabscess-like structures have been reported. 41,46 However, DIP is more commonly found as a single lesion, whereas unilesional MF is uncommon.…”

Section: -34mentioning

confidence: 99%

“…41,46 However, DIP is more commonly found as a single lesion, whereas unilesional MF is uncommon. 40,44,[48][49][50] In addition, MF is more likely to involve sun-protected skin and show a variety of clinical morphologies. 4,48 On biopsy, the presence of spongiosis, dyskeratotic keratinocytes, extravasated erythrocytes, pigment incontinence, dermal edema, and/or numerous eosinophils are more supportive of a diagnosis of DIP.…”

Section: -34mentioning

confidence: 99%

“…Patients with anticonvulsant-induced pseudolymphoma may develop a characteristic pseudolymphoma syndrome, 40,41,43,44 which many experts include within the spectrum of hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms. 42,45,47,48 Uncommonly, this syndrome may occur with medications other than anticonvulsants.…”

Section: -34mentioning

confidence: 99%

“…Lesions are often associated with a new medication and resolve completely with discontinuation of the offending drug, although that may take several months. [40][41][42] The clinical presentation ranges from a diffuse, maculopapular eruption to papules, plaques, and/or nodules that may be solitary or multiple. [41][42][43][44][45][46] Rare cases of erythroderma have been reported (Figure 4, A and B).…”

Section: -34mentioning

confidence: 99%

See 3 more Smart Citations

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Arps

Chen

Fullen

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, and genetic features must be considered carefully because there are few sensitive and specific clues to the diagnosis. Moreover, an appropriate clinical presentation is essential to the diagnosis and helps to favor or exclude inflammatory/reactive processes. Herein, we discuss 3 important inflammatory dermatoses that may closely simulate mycosis fungoides, and we review the use of ancillary studies in these challenging cases.

show abstract

Section: -34mentioning

confidence: 99%

Section: -34mentioning

confidence: 99%

Section: -34mentioning

confidence: 99%

Section: -34mentioning

confidence: 99%

See 2 more Smart Citations

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Arps

Chen

Fullen

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…18 Perhaps AHS is an appropriate name for the former, and the latter entity should be identified as "cutaneous pseudolymphoma," or "mycosis fungoides-like lesions," as described in 1991. 20 …”

Section: 16mentioning

confidence: 99%

Anticonvulsant Hypersensitivity Syndrome

2001

IJPHARM

View full text Add to dashboard Cite

Background: Anticonvulsant hypersensitivity syndrome (AHS) is a serious but poorly understood and little known disease. It has been variously described in the literature since 1934. Fatalities are rare but have been reported.Methods: A MEDLINE search was undertaken from 1991 to present, using the keywords "anticonvulsant," "phenytoin," and "hypersensitivity." English language articles and their endnotes were reviewed, and neurologists, dennatologists, and specialists in hematology-oncology were consulted.Results: A case of AHS is described. Investigators have reported epidemiologic data and described the pathophysiology, diagnostic criteria, and management options.Conclusions: Family physicians should be aware of the AHS because of the high likelihood that patients with this syndrome will come first to their primary care physicians for care. Certain anticonvulsant medications have a high degree of cross-reactivity, the incidence of AHS is higher among first-degree relatives, and the disorder mimics systemic infection. If AHS is suspected, the antiepileptic drug should be discontinued. Supportive care should be directed to the appropriate organ systems, with particular attention to skin, eyes, and liver. Corticosteroid treatment might be effective in reversing the drug reactions, but it is not recommended in cases of suspected or actual infection because of the increased risk of immunocompromise, sepsis, and associated mortality. (J Am Board Fam Praet 2000;13:

show abstract

Hydantoin-Induced Cutaneous Pseudolymphoma With Clinical, Pathologic, and Immunologic Aspects of Sézary Syndrome

D’Incan¹

1992

Arch Dermatol

View full text Add to dashboard Cite

show abstract

Mycosis fungoides—like lesions associated with phenytoin and carbamazepine therapy

Cited by 80 publications

References 14 publications

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Anticonvulsant Hypersensitivity Syndrome

Hydantoin-Induced Cutaneous Pseudolymphoma With Clinical, Pathologic, and Immunologic Aspects of Sézary Syndrome

Contact Info

Product

Resources

About