Mycothiol Peroxidase Activity as a Part of the Self-Resistance Mechanisms against the Antitumor Antibiotic Cosmomycin D

Abstract

Anthracycline compounds are DNA intercalating agents widely used in cancer chemotherapeutic protocols. This work focused on the self-resistance mechanisms developed by the cosmomycin-producing bacterium Streptomyces olindensis .

A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel Strain Streptomyces sp. 21So2-11 Isolated from Antarctic Soil

“…Microorganisms have developed different strategies to prevent self-toxicity because they must be resistant to the biological effects of bioactive compounds to survive during natural product production/accumulation [ 61 ]. As the function of bacterial defense against self-toxicity is intimately linked to virulence factors and antibiotic resistance genes [ 62 , 63 ], abundant pathogenic and virulence-related genes as well as antibiotic resistance genes found in the 21So2-11 genome can contribute to preventing the self-toxicity of bacteria caused by secondary metabolites, including auroramycin, capreomycin, enteromycin, gaudimycin, leucomycin, naphthomycin, neomediomycin, streptolydigin and kinamycin. At the same time, these virulence factors and antibiotic resistance genes can provide strain 21So2-11 with an advantage in competing with organisms inhabiting the same habitat, especially those that are sensitive to the antibiotics produced by strain 21So2-11.…”