Mycotoxin exposure and pregnancy

Gönenç, İ̇lknur Münevver; Sezer, Neslihan Yılmaz; Yılmaz, Serkan

doi:10.1080/10408444.2020.1803791

Cited by 18 publications

(5 citation statements)

References 54 publications

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“…Importantly, FGR in human fetuses has been associated with maternal exposure to environmental pollutants (Gómez-Roig et al, 2021). For instance, maternal exposure to airborne pollutants, mycotoxins, phthalates, as well as to drinking water contaminated with nitrate and pesticide, has been linked to a higher occurrence of FGR (Alvito and Pereira-da-Silva, 2022; Bach et al, 2015; Chang et al, 2022; Gönenç et al, 2020; Macchi et al, 2021; Santos et al, 2021; Smith et al, 2017)As our study demonstrates for the first time a small but consistent growth delay in mice embryos upon maternal exposure to an environmental level of CBZ, further studies are needed to determine whether the mild growth restriction found in the CBZ-exposed mice at GD9.5 persists throughout gestation, in order to conclude whether CBZ from the environment may induce FGR in mice, which may be comparable to clinical evidences in humans (Dilworth et al, 2011). If so, it would appear necessary to begin exploring whether higher incidences of FGR are detected in regions with relatively high levels of CBZ in treated wastewater, surface water and groundwater.…”

Section: Resultsmentioning

confidence: 99%

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Douek-Maba

Kalev-Altman

Mordehay

et al. 2023

Preprint

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As chemical pollution is constantly increasing, the impact on the environment and public health must be investigated. This study focuses on the anticonvulsant drug carbamazepine (CBZ), which is ubiquitously present in the environment. Due to its physicochemical properties and stability during wastewater treatment, CBZ is detected in reclaimed wastewater, surface water and groundwater. In water-scarce regions heavily relying on treated wastewater for crop irrigation, CBZ is detected in arable land, produce and even in humans consuming crops irrigated with recealimed wastewater. Although environmental levels of CBZ are very low, risks associated with unintentional exposure to CBZ are essential to be revealed. In perinatal medicine, CBZ is a teratogen; its prescription to pregnant women increases the risk for fetal malformations. This raises the concern of whether environmental exposure to CBZ may also impact embryogenesis. Studies in zebrafish and chick embryos or in cell culture have indicated negative outcomes upon exposure to low CBZ levels. Yet, these systems do not recapitulate the manner by which human fetuses are exposed to pharmaceuticals via maternal uptake. Here, we employed the mouse model to determine whether maternal exposure to environmental-relevant doses of CBZ will impact embryonic development. No effects on fertility, number of gestation sacs, gross embryonic malformations or fetal survival were detected. Yet, embryos were growth-delayed compared to controls (p=0.0011), as manifested in lower embryonic stage and somite number, earlier morphological features and reduction in mitotically-active cells. This study provides the first evidence for the effect of environmental concentration of CBZ on the developmental kinetics of maternally-exposed mammalian embryos. While the developmental delay was relatively modest, its consistency in high number of biological replicates, together with the known implication of developmental delay on post-natal health, calls for further in-depth risk analyses to reveal the effects of pharmaceuticals released to the environment on public health.

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Section: Resultsmentioning

confidence: 99%

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Douek-Maba

Kalev-Altman

Mordehay

et al. 2023

Preprint

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“…Some data suggests that mycotoxins can negatively impact a pregnancy. These potential unfavorable factors include lower birth weight, neonatal jaundice, fetal loss, fetal anomalies, preterm birth, maternal anemia, and hypertension [18]. When compared to the World Health Organization (WHO) standard growth curves, aggregate assessments of child growth in LMICs portray an alarmingly constant picture of serious development failure.…”

Section: Effect Of Environmental Toxins On Pregnancymentioning

confidence: 99%

Effects of Pollution on Pregnancy and Infants

Rani¹,

Dhok²

2023

Cureus

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The fetus is particularly susceptible to environmental contaminants as it is developing at the time of pregnancy and is, therefore, more susceptible to their effects. Pregnancy loss, which includes stillbirth and spontaneous abortion (miscarriage), preterm labor and delivery, and neonatal death, is the worst pregnancy outcome. Stunting and its related health and developmental effects are particularly common in populations living in underdeveloped countries or those exposed to high levels of particle pollution. Several environmental toxins can affect an embryo, fetus, or infant as they are developing. This study explores the following questions: What part do pesticides, heavy metals, dioxin derivatives, and polychlorinated diphenyl compounds play as macroenvironmental pollutants in mutagenesis and teratogenesis? What effects do substances that exposed persons have considerable control over, such as alcohol, narcotics, and tobacco smoke, have on the microenvironment? What consequences should practitioners be aware of these toxins in terms of ethics and the law? This study seeks to assess pertinent primary scientific studies on how pollution affects the health of the fetus and newborn during pregnancy.

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“…Nevertheless, the evidence for the association between mycotoxin exposure during pregnancy and newborn and infant growth outcomes remains inconsistent and are mainly limited with AFs and FBs. While certain studies have documented an association between exposure to certain mycotoxin groups and a higher risk of adverse birth outcomes and suboptimal infant growth, others have indicated no clear association or have even suggested a positive correlation with improved growth (Gönenç et al, 2020; Kyei et al, 2020; Tesfamariam et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Prenatal ochratoxin A exposure, birth outcomes and infant growth in rural Burkina Faso: a human biomonitoring sub-study from the MISAME-III trial

Bastos-Moreira,

Argaw,

Dailey-Chwalibóg

et al. 2024

Preprint

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Mycotoxin exposure during pregnancy has been associated with adverse birth outcomes and poor infant growth in low- and middle-income countries. We assessed multiple biomarkers and metabolites of exposure to mycotoxins during pregnancy and their associations with birth outcomes and infant growth in 305 pregnant participants, between 30 and 34 completed weeks of gestation, in rural Burkina Faso. In this study, whole blood microsamples were analyzed for mycotoxin concentrations using ultra-performance liquid chromatography coupled to tandem mass spectrometry. Unadjusted and adjusted associations between mycotoxin exposure, and birth outcomes and infant growth at 6 months were estimated using linear regression models for continuous outcomes and linear probability models with robust variance estimation for binary outcomes. Infant growth trajectories from birth to 6 months were compared by exposure status using mixed-effects models with random intercept for the individual infant and random slope for the infant’s age. Ochratoxin A (OTA) exposure was detected in 50.8% of the study participants, with aflatoxin G1, aflatoxin M1, cyclopiazonic acid, deoxynivalenol and T-2-toxin being detected in the range of 0.33% and 2.31% of the population. We found no statistically significant (allp≥ 0.05) associations between OTA exposure, and birth outcomes and infant growth. Despite this, the findings indicate a significant presence of ochratoxin A among pregnant participants. Public health policies and nutrition-sensitive interventions must ensure that OTA exposure is reduced in Burkina Faso.

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Mycotoxin exposure and pregnancy

Cited by 18 publications

References 54 publications

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

Effects of Pollution on Pregnancy and Infants

Prenatal ochratoxin A exposure, birth outcomes and infant growth in rural Burkina Faso: a human biomonitoring sub-study from the MISAME-III trial

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