Mycotoxin production profiles ofPenicillium vulpinum (Cooke &amp; Massee) Seifert &amp; Samson strains

Козловский, А. Г.; Vinokurova, N. G.; Желифонова, В. П.

doi:10.1007/bf02757254

Cited by 8 publications

(5 citation statements)

References 3 publications

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“…The brevianamid F content of the dried cassava product samples was highest in fine white gari (44.0 µg/kg) and the lowest in fufu flour (7.1 µg/kg). Fellutanine A is one of the bio-active diketopiperazine alkaloids often produced by Penicillium fellutanum and Penicillium simplicissimum [ 56 ], which is also a non-annulated analogue of cyclo (L-Trp-L-Trp). This implied that fellutanine can also be produced from the amino acid tryptophan during fermentation [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…Fellutanine A is one of the bio-active diketopiperazine alkaloids often produced by Penicillium fellutanum and Penicillium simplicissimum [ 56 ], which is also a non-annulated analogue of cyclo (L-Trp-L-Trp). This implied that fellutanine can also be produced from the amino acid tryptophan during fermentation [ 56 ]. The concentration range of this metabolite in the samples was 0.02 µg/kg to 4.14 µg/kg, with fine white gari having the highest, and tapioca the lowest, concentrations.…”

Section: Resultsmentioning

confidence: 99%

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Occurrence of Regulated Mycotoxins and Other Microbial Metabolites in Dried Cassava Products from Nigeria

Abass

Awoyale

Sulyok

et al. 2017

Toxins

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Dried cassava products are perceived as one of the potential sources of mycotoxin ingestion in human foods. Processing either contributes to the reduction of toxins or further exposes products to contamination by microorganisms that release metabolic toxins into the products. Thus, the prevalence of microbial metabolites in 373 processed cassava products was investigated in Nigeria. With the use of liquid chromatography tandem-mass spectrometry (LC-MS/MS) for the constituent analysis, a few major mycotoxins (aflatoxin B1 and G1, fumonisin B1 and B2, and zearalenone) regulated in food crops by the Commission of the European Union were found at concentrations which are toxicologically acceptable in many other crops. Some bioactive compounds were detected at low concentrations in the cassava products. Therefore, the exposure of cassava consumers in Nigeria to regulated mycotoxins was estimated to be minimal. The results provide useful information regarding the probable safety of cassava products in Nigeria.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Occurrence of Regulated Mycotoxins and Other Microbial Metabolites in Dried Cassava Products from Nigeria

Abass

Awoyale

Sulyok

et al. 2017

Toxins

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“…1078-01). It is known that aflatoxins are the waste products of the Aspergillus flavus fungi [11], [12], while patulinof the Penicillium expansum fungi [5], [13], [14]. Mycotoxins are synthesized from a rather limited number of products of the main metabolism, such as acetate, mevalonate, and certain amino acids.…”

Section: Resultsmentioning

confidence: 99%

Toxins and Mechanisms of Their Interaction in Fruit Wines

Gnetko¹,

Nerovnykh²,

Гишева³

et al. 2019

IJITEE

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The purpose of the work was to ensure the environmental safety of fruit wines based on studying the content of secondary metabolites of mold fungi – mycotoxins – and their properties in them. The study objects included different varieties of apples that were damaged in a different way. The whole apples that were not damaged by pests and diseases were used as a reference group. To define the content of patulin and aflatoxins A and G, thin layer chromatography and high-performance liquid chromatography were used. In order to define the mass concentrations of amino acids, the method of liquid ion-exchange eluent chromatography was used. The analysis of wine materials produced from apples that had various types of damage has showed that they contained mycotoxins, namely, aflatoxins A and G and patulin. It has been determined that the degree of contamination of the apples surface with mold fungi depends on the type of the fruit damage. The content of toxins increases in the following sequence: mechanically damaged apples < pest damaged apples < apples damaged by diseases. All objects were characterized by a considerable content of patulin. An attempt has been made to define possible areas for the patulin synthesis with mold fungi. The impact of mold fungi on the composition of amino acids in fruit materials has been studied. The difference in the concentration of amino acids in low alcoholic and highly alcoholic environments has been revealed. It has been defined that the reason for obtaining fermented juices with a depleted amino acid composition is the use of the fruits damaged with rot. The increase in the content of certain amino acids in fermented alcoholized juices indicates the inhibitory effect of the alcoholic medium on the metabolic processes of mold fungi and a decrease in their enzymatic activity. The mechanism of the interaction between patulin and amino acids of fruit materials has been explained.

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“…In the present study, a comparison between the effect of PAT and P. vulpinum culture filtrate on some enzymatic activities was investigated. Kozlovskii et al [ 4 ] reported that the culture filtrate of P. vulpinum comprises several alkaloids (cyclopeptin, cyclopenin, meleagrin, and oxaline) that possess antibiotic activities and may become dangerous due to possible synergistic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Patulin (4-hydroxy-4 H -furo[3,2-c] pyran-2(6 H )-one) (PAT, Figure 1 ) is a mycotoxin produced by large number of fungal species within several genera such as Aspergillus , Byssochlamys, Eupenicillium , Paecilomyces , and Penicillium [ 1 ], including Penicillium vulpinum (Cooke & Massee) Seifert & Samson (formerly P. claviforme ), a phytotoxic fungus associated with decaying plant roots [ 2 , 3 ]. This fungal species was reported to produce several mycotoxins such as α-cyclopiazonic acid, griseofulvin, PAT, and roquefortine C, in addition to alkaloids (cyclopeptin, cyclopenin, meleagrin, and oxaline) [ 4 ]. Of these mycotoxins, PAT is the most potent mycotoxin and is frequently found in vegetables and fruits (in particular in ripe apples and their juices) [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Patulin from Penicillium vulpinum on the Activity of Glutathione-S-Transferase and Selected Antioxidative Enzymes in Maize

Ismaiel

Papenbrock

2017

IJERPH

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Abstract:The mycotoxin patulin (PAT) was purified from Penicillium vulpinum CM1 culture that has been isolated from a soil cultivated with maize. The effect of PAT and of a fungal culture filtrate on the activities of glutathione-S-transferase (GST) and some antioxidant enzymes viz. ascorbate peroxidase (APX), glutathione reductase (GR), dehydroascorbate reductase (DHAR) and monodehydroascorbate reductase (MDHAR) was investigated in roots and shoots of 8-day-old maize seedlings. PAT and culture filtrate caused significant reduction effects in a dose-related manner on the total GST activity. Upon application of the high PAT concentration (25 µg·mL −1 ) and of the concentrated fungal filtrate (100%, v/v), the reduction in GST activity of roots was 73.8-76.0% and of shoots was 60-61.7%. Conversely, significant increases in the activities of antioxidant enzymes were induced. Application of 25 µg·PAT·mL −1 increased APX, GR, DHAR, and MDHAR activity of root by 2.40-, 2.00-, 1.24-, and 2.16-fold, respectively. In shoots, the enzymatic activity was increased by 1.57-, 1.45-, 1.45-, and 1.61-fold, respectively. Similar induction values of the enzymatic activity were obtained upon application of the concentrated fungal filtrate. This is the first report describing the response of GST and antioxidant enzyme activities of plant cells to PAT toxicity.

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Mycotoxin production profiles ofPenicillium vulpinum (Cooke & Massee) Seifert & Samson strains

Cited by 8 publications

References 3 publications

Occurrence of Regulated Mycotoxins and Other Microbial Metabolites in Dried Cassava Products from Nigeria

Occurrence of Regulated Mycotoxins and Other Microbial Metabolites in Dried Cassava Products from Nigeria

Toxins and Mechanisms of Their Interaction in Fruit Wines

Effect of Patulin from Penicillium vulpinum on the Activity of Glutathione-S-Transferase and Selected Antioxidative Enzymes in Maize

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