Mycotoxin Removal by Lactobacillus spp. and Their Application in Animal Liquid Feed

Ragoubi, Chaima; Quintieri, Laura; Greco, Donato; Mehrez, Amel; Maatouk, Imed; D’Ascanio, Vito; Landoulsi, Ahmed; Avantaggiato, Giuseppina

doi:10.3390/toxins13030185

Cited by 35 publications

(9 citation statements)

References 57 publications

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“…Due the high toxicity and exposure risk associated with AFB1, many methods are developed to mitigate its adverse effects. Among them, the use of microbials to remove AFB1 from materials has garnered significant attention, particularly in the feed industry [34]. A lot of microbial species, such as Lactobacillus rhamnosus, Accharomyces cerevisiae, and Leurotus eryngii, have been identified for their ability to remove AFB1, achieving an average clearance rate of 86% [19,[35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Auricularia auricular Adsorbs Aflatoxin B1 and Ameliorates Aflatoxin B1-Induced Liver Damage in Sprague Dawley Rats

Huang

Jiao

et al. 2023

Foods

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Aflatoxin B1 (AFB1), as a class I carcinogen, poses a substantial health risk to individuals. Contamination of food sources, particularly grains and nuts, with Aspergillus flavus (A. flavus) contributes to the prevalence of AFB1. The impact of global warming has spurred research into the development of AFB1 prevention technologies. While edible fungi have shown potential in detoxifying AFB1, there is a scarcity of literature on the application of Auricularia auricular (A. auricular) in this context. This study aimed to investigate the ability and underlying mechanism of A. auricular mycelia to adsorb aflatoxin B1, as well as evaluate its protective effects on the AFB1-induced liver damage in SD rats. Additionally, the effects of temperature, time, pH, and reaction ratio on the adsorption rate were examined. Combining thermodynamic and kinetic data, the adsorption process was characterized as a complex mechanism primarily driven by chemical adsorption. In SD rats, the A. auricular mycelia exhibited alleviation of AFB1-induced liver damage. The protective effects on the liver attributed to A. auricular mycelia may involve a reduction in AFB1 absorption in the intestine, mitigation of oxidative stress, and augmentation of second-phase detoxification enzyme activity. The adsorption method for AFB1 not only ensures safety and non-toxicity, but also represents a dietary regulation strategy for achieving effective defense against AFB1.

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Section: Discussionmentioning

confidence: 99%

Auricularia auricular Adsorbs Aflatoxin B1 and Ameliorates Aflatoxin B1-Induced Liver Damage in Sprague Dawley Rats

Huang

Jiao

et al. 2023

Foods

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“…Besides bacteriocins, inhibition of the growth of pathogenic bacteria, yeasts, and molds gained by the synergistic action of the LAB metabolome, where lactic acid, acetic acid, hydrogen peroxide, lactate peroxidase, lysozyme, and reuterin can affect the surrounding microbiome [35] and decrease total plate counts. LAB are also well-known as potent participants in mycotoxin biocontrol [13,36,37]. L. plantarum and L. brevis are well-known as inoculants for ensilaging; however, the aim of their usage usually is in their volatile organic carbon production and not their biocontrol capability [1].…”

Section: Discussionmentioning

confidence: 99%

Microbiological and Toxicological Evaluation of Fermented Forages

et al. 2022

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Several feed preservation methods can ensure lower mycotoxin contamination levels enter the food life cycle, and a relatively common wet preservation method of forage plant materials is fermentation. This study aimed to characterize the microbiological state and mycotoxin contamination of fermented silages and haylages (corn, alfalfa, rye, and triticale), their main microbiota, and isolation of bacteria with mycotoxin resistance. Bacteria that remain viable throughout the fermentation process and possess high mycotoxin resistance can have a biotechnological benefit. Lactic acid bacteria, primarily found in corn silage, were Lactiplantibacillus plantarum isolates. Meanwhile, a high percentage of alfalfa silage and haylage was characterized by Lactiplantibacillus pentosus. In rye silage and haylage samples, Pediococci were the typical bacteria. Bacterial isolates were characterized by deoxynivalenol and zearalenon resistance. Some of them were sensitive to aflatoxin B1, while ochratoxin A caused 33–86% growth inhibition of the cultures. The mycotoxin resistant organisms are under further research, aiming for mycotoxin elimination in feed.

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“…L. acidophilus CIP 76.13T and L. delbrueckii subsp. bulgaricus CIP 101027T cells removed up to 57% of ZEA ( Ragoubi et al, 2021 ). For L. paracasei and L. lactis , the maximum sorption effectiveness was 53.3%, and 41.0%, respectively ( Rogowska et al, 2019 ; Złoch et al, 2020 ).…”

Section: Enzymatic and Physical Removal Of Fusarium ...mentioning

confidence: 99%

Fusarium biocontrol: antagonism and mycotoxin elimination by lactic acid bacteria

Krishnan,

Nampoothiri,

Suresh

et al. 2024

Front. Microbiol.

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Mycotoxins produced by Fusarium species are secondary metabolites with low molecular weight formed by filamentous fungi generally resistant to different environmental factors and, therefore, undergo slow degradation. Contamination by Fusarium mycotoxins in cereals and millets is the foremost quality challenge the food and feed industry faces across the globe. Several types of chemical preservatives are employed in the mitigation process of these mycotoxins, and they help in long-term storage; however, chemical preservatives can be used only to some extent, so the complete elimination of toxins from foods is still a herculean task. The growing demand for green-labeled food drives to evade the use of chemicals in the production processes is getting much demand. Thus, the biocontrol of food toxins is important in the developing food sector. Fusarium mycotoxins are world-spread contaminants naturally occurring in commodities, food, and feed. The major mycotoxins Fusarium species produce are deoxynivalenol, fumonisins, zearalenone, and T2/HT2 toxins. Lactic acid bacteria (LAB), generally regarded as safe (GRAS), is a well-explored bacterial community in food preparations and preservation for ages. Recent research suggests that LAB are the best choice for extenuating Fusarium mycotoxins. Apart from Fusarium mycotoxins, this review focuses on the latest studies on the mechanisms of how LAB effectively detoxify and remove these mycotoxins through their various bioactive molecules and background information of these molecules.

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Mycotoxin Removal by Lactobacillus spp. and Their Application in Animal Liquid Feed

Cited by 35 publications

References 57 publications

Auricularia auricular Adsorbs Aflatoxin B1 and Ameliorates Aflatoxin B1-Induced Liver Damage in Sprague Dawley Rats

Auricularia auricular Adsorbs Aflatoxin B1 and Ameliorates Aflatoxin B1-Induced Liver Damage in Sprague Dawley Rats

Microbiological and Toxicological Evaluation of Fermented Forages

Fusarium biocontrol: antagonism and mycotoxin elimination by lactic acid bacteria

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