Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

Li, You; Nepovimová, Eugenie; Valko, Marián; Wu, Qinghua; Kuča, Kamil

doi:10.1007/s00204-022-03423-x

Cited by 15 publications

(8 citation statements)

References 89 publications

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“…From the turquoise module, 630 promising candidates were identified ( Figure 3E ). We performed GO, and KEGG analysis on these genes, and not surprisingly these genes were associated with Thyroid hormone synthesis, Ubiquitin mediated proteolysis, Nucleotide excision repair, Cellular senescence, and histone acetyltransferase complex ( Figure 3F ), which are related to oxygen metabolism/hypoxia ( 34 – 38 ).…”

Section: Resultsmentioning

confidence: 99%

Hypoxia-associated genes predicting future risk of myocardial infarction: a GEO database-based study

Zhang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundPatients with unstable angina (UA) are prone to myocardial infarction (MI) after an attack, yet the altered molecular expression profile therein remains unclear. The current work aims to identify the characteristic hypoxia-related genes associated with UA/MI and to develop a predictive model of hypoxia-related genes for the progression of UA to MI.Methods and resultsGene expression profiles were obtained from the GEO database. Then, differential expression analysis and the WGCNA method were performed to select characteristic genes related to hypoxia. Subsequently, all 10 hypoxia-related genes were screened using the Lasso regression model and a classification model was established. The area under the ROC curve of 1 shows its excellent classification performance and is confirmed on the validation set. In parallel, we construct a nomogram based on these genes, showing the risk of MI in patients with UA. Patients with UA and MI had their immunological status determined using CIBERSORT. These 10 genes were primarily linked to B cells and some inflammatory cells, according to correlation analysis.ConclusionOverall, GWAS identified that the CSTF2F UA/MI risk gene promotes atherosclerosis, which provides the basis for the design of innovative cardiovascular drugs by targeting CSTF2F.

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Section: Resultsmentioning

confidence: 99%

Hypoxia-associated genes predicting future risk of myocardial infarction: a GEO database-based study

Zhang

et al. 2023

Front. Cardiovasc. Med.

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“…During MSCs senescence, RB is in a state of low phosphorylation, which inhibits the expression of the E2F1 factor closely related to the S phase and leads to the permanent arrest of the cell cycle [ 78 ]. Studies [ 79 ] have shown that mycotoxins can induce cell senescence, increase the expression of p16 and p21, and decrease the expression of Cyclin D1 and CDK4, leading to cell-cycle arrest in senescent cells. BZBS significantly upregulated Cyclin D1, CDK4, and transcription factor E2F1.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Bazi Bushen capsule in delaying the senescence of mesenchymal stem cells based on network pharmacology and experimental validation

Zhang,

Wang,

Song

et al. 2024

Heliyon

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“…It is an important sign of DDR activation and necessary for the formation of repair complexes at DSBs 83–85 . Members of the phosphatidylinositol 3‐kinase‐related kinase family (PI3KK), such as ATM–Chk2 and ATR–Chk1 kinases, frequently phosphorylate H2A.X, but may not be the only ones to do so 86 . ATM is generally activated by the binding of the MRE11–RAD50–NBS1 complex to DNA breaks 87 .…”

Section: Morphological Features Of Senescence and Their Role In Tumor...mentioning

confidence: 99%

“… 83 , 84 , 85 Members of the phosphatidylinositol 3‐kinase‐related kinase family (PI3KK), such as ATM–Chk2 and ATR–Chk1 kinases, frequently phosphorylate H2A.X, but may not be the only ones to do so. 86 ATM is generally activated by the binding of the MRE11–RAD50–NBS1 complex to DNA breaks. 87 The subsequent attraction of DNA damage checkpoint protein 1 (MDC1) by γH2A.X generates a complex feedback loop to maintain γH2A.X amplification and stability 88 , 89 ; therefore, a framework is developed for further recruitment and accumulation of DNA repair components, and DSB repair can therefore be carried out through nonhomologous end joining (NHEJ) and homologous recombination.…”

Section: Morphological Features Of Senescence and Their Role In Tumor...mentioning

confidence: 99%

Cellular senescence in cancer: molecular mechanisms and therapeutic targets

Jin,

Duan,

et al. 2024

MedComm

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Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades, research into the role of cellular senescence on tumor progression has received widespread attention. While how senescence limits the course of cancer is well established, senescence has also been found to promote certain malignant phenotypes. The tumor‐promoting effect of senescence is mainly elicited by a senescence‐associated secretory phenotype, which facilitates the interaction of senescent tumor cells with their surroundings. Targeting senescent cells therefore offers a promising technique for cancer therapy. Drugs that pharmacologically restore the normal function of senescent cells or eliminate them would assist in reestablishing homeostasis of cell signaling. Here, we describe cell senescence, its occurrence, phenotype, and impact on tumor biology. A “one‐two‐punch” therapeutic strategy in which cancer cell senescence is first induced, followed by the use of senotherapeutics for eliminating the senescent cells is introduced. The advances in the application of senotherapeutics for targeting senescent cells to assist cancer treatment are outlined, with an emphasis on drug categories, and the strategies for their screening, design, and efficient targeting. This work will foster a thorough comprehension and encourage additional research within this field.

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Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

Cited by 15 publications

References 89 publications

Hypoxia-associated genes predicting future risk of myocardial infarction: a GEO database-based study

Hypoxia-associated genes predicting future risk of myocardial infarction: a GEO database-based study

Mechanism of Bazi Bushen capsule in delaying the senescence of mesenchymal stem cells based on network pharmacology and experimental validation

Cellular senescence in cancer: molecular mechanisms and therapeutic targets

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