Mycotoxins and mycotoxigenic fungi in aquaculture and seafood: a review and new perspective

Alizadeh, Adel Mirza; Khaneghah, Amin Mousavi; Hosseini, Hedayat

doi:10.1080/15569543.2021.2010759

Cited by 7 publications

(5 citation statements)

References 37 publications

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“…Cells were grown in William's E medium supplemented with 10% fetal calf serum (FCS), 100 U/mL penicillin, 100 µg/mL streptomycin, 2 mM glutamine, 5 µg/mL insulin, and 50 µM hydrocortisone hemisuccinate. HepaRG cells (passages [13][14][15][16][17][18][19] were seeded at a density of 26,000 cells/cm 2 in 96-well plates.…”

Section: • Heparg Cellsmentioning

confidence: 99%

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An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines

Marzougui

Hégarat

Hogeveen

et al. 2023

IJMS

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This study investigates the genotoxicity and cytotoxicity of C17-sphinganine analog mycotoxin (C17-SAMT) using in vitro assays. C17-SAMT was previously identified as the cause of unusual toxicity in cultured mussels from the Bizerte Lagoon in northern Tunisia. While a previous in vivo genotoxicity study was inconclusive, in vitro results demonstrated that C17-SAMT induced an increase in micronucleus formation in human lymphoblastoid TK6 cells at concentrations of 0.87 µM and 1.74 µM. In addition, multiparametric cytotoxicity assays were performed in the human hepatoma HepaRG cell line, which showed that C17-SAMT induced mitochondrial dysfunction, decreased cellular ATP levels, and altered the expression of various proteins, including superoxide dismutase SOD2, heme oxygenase HO-1, and NF-κB. These results suggest that C17-SAMT is mutagenic in vitro and can induce mitochondrial dysfunction in HepaRG cells. However, the exact mode of action of this toxin requires further investigation. Overall, this study highlights the potential toxicity of C17-SAMT and the need for further research to better understand its effects.

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Section: • Heparg Cellsmentioning

confidence: 99%

“…have contaminated sediments and mussels in shellfish farming areas [15]. Recently, aflatoxins (AFs), ochratoxins (OTAs), deoxynvalenol (DON), and zearalenone (ZEN) [16], well-known for their contamination of terrestrial ecosystems and for their hazardous effects to humans and animals, have been also detected in seafood.…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines

Marzougui

Hégarat

Hogeveen

et al. 2023

IJMS

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“…Zearalenone and its metabolites (αzearalenol) bind to the estrogen receptor and induce a range of reproductive issues due to their structural similarities to estradiol (McCauley et al, 2017). ZEN was related with feminization, decreased libido, lower blood testosterone levels, decreased testicular weight, and altered spermatogenesis in boars (Mirza Alizadeh et al, 2022). In pigs, ZEN poisoning caused vulvovaginitis, fetal mortality, anestrus, reduced LH and P4 production, delayed postweaning estrus, and promoted germinal epithelial degeneration (Imran et al, 2020).…”

Section: Effects Of Zearalenone On Animal Healthmentioning

confidence: 99%

Different Molds and their Toxins: As Contaminants in one Health Perspective

2023

IJAB

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“…Feeding is considered of fundamental importance for all segments of animal production, including fish farming; it can represent more than 81% of production costs, depending on the adopted cultivation strategies [ 1 ]. Feeds formulated for fish must meet their nutritional needs; however, their composition can be compromised as it is possible to contain negative microbiological interference, possibly caused by inadequate storage [ 2 ]. Fungi and their mycotoxins can not only influence the texture and chemical composition of fish feeds, but they can also stimulate the proliferation of tumor cells in fish [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of Mycotoxigenic Fungi in Fish Farm Water and Fumonisins in Feeds for Farmed Colossoma macropomum

Sousa Terada-Nascimento,

Vieira Dantas-Filho,

Temponi-Santos

et al. 2023

Toxics

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This study aimed to evaluate the occurrence of mycotoxigenic fungi in fish farm water and mycotoxins in feeds for farmed tambaqui (Colossoma macropomum). A total of 40 samples of freshwater from fish farms and 16 samples of feed were collected and analyzed for microbiology. A total of five species of free-living fungi were identified in fish farms: Aspergillus fumigatus, Penicillium citrinum, P. implicatum, Fusarium oxysporum and Alternaria alternata. These fungi species were counted in water samples at 35.14 CFU mL−1 and 24.69 CFU mL−1 in the dry seasons. In all fish farms, there was a higher abundance of fungi species in the rainy season. During visits to the fish farmers, it was possible to verify poor feed storage conditions. Concerning mutations in blood cells, in tambaqui (C. macropomum), a total of 159 anomalies were found, and in Leptodactylus petersii, 299 anomalies were found, with higher incidences in conditions above 1.0 CFU mL−1 in log10(x+1) fungi and in the rainy season. The occurrence of mycotoxicological contamination was confirmed in 81.25% of the analyzed samples. The quantified mycotoxin was Fumonisins B1 + B2 (375 to 1418 μg kg−1). Pearson’s correlation analysis showed a significant positive correlation between Fumonisins and feed samples (r = 0.83). There was also a significant positive correlation between the abundance of fungi in water and the quantification of Fumonisins (r = 0.79). Based on the results obtained, it can be concluded that free-living fungi can be used as bioindicators of water quality in fish farms. Consequently, the lack of good management practices caused microbiological contamination of the aquatic environment.

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Mycotoxins and mycotoxigenic fungi in aquaculture and seafood: a review and new perspective

Cited by 7 publications

References 37 publications

An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines

An Evaluation of the Cytotoxic and Genotoxic Effects of the Marine Toxin C17-SAMT in Human TK6 and HepaRG Cell Lines

Different Molds and their Toxins: As Contaminants in one Health Perspective

Monitoring of Mycotoxigenic Fungi in Fish Farm Water and Fumonisins in Feeds for Farmed Colossoma macropomum

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