Mycoviruses: A New Dimension in Microbiology

Bozarth, R. F.

doi:10.2307/3428096

Cited by 11 publications

(13 citation statements)

References 44 publications

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“…Although mycoviruses have been isolated from a number of economically and industrially important fungi, such as Ustilago maydis, Helminthosporium maydis, Penicillium chrysogenurn and Aspergillus niger (Bozarth, 1972; Lemke & Nash,1g74), evidence is limited concerning the regulatory function fungal metabolites may exert in controlling virus replication and, eventually, survival of a virus in a fungal species.…”

Section: Introductionmentioning

confidence: 99%

Patulin Inhibition of Mycovirus Replication in Penicillium stoloniferum

Detroy¹,

Still²

1976

Journal of General Microbiology

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SUMMARY Penicillium stolonferum ~~~1 , 5 2 6 7contains two electrophoretically distinct viruses (PsV-F and PsV-S). An in vivo system was developed to test whether a number of fungal metabolites had antiviral properties on PsV-F replication in P. stoloniferum. Preliminary results indicated that the mycotoxin patulin can block mycovirus replication. Portions of 48 h mycelium were incubated in the presence of varying levels of patulin, and after an additional 48 h incubation, PsV-F content was measured in Ezso units by polyacrylamide gel electrophoresis. Patulin at I I , 16 and 20 pg/mg dry wt mycelia blocked PsV-F replication 26, 61 and 71 %, respectively, compared with untreated controls. At these levels, host biomass RNA and protein synthesis were minimally affected. Non-proliferating fungal mycelium is capable of continued support of PsV-F replication, which is sensitive to patulin. Apparently, inhibitory doses of patulin stimulated PsV-S replication during this 48 h incubation. The preferential action of patulin may arise from metabolite binding to functional enzymes required for virus replication.

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Section: Introductionmentioning

confidence: 99%

Patulin Inhibition of Mycovirus Replication in Penicillium stoloniferum

Detroy¹,

Still²

1976

Journal of General Microbiology

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“…A complete list of mycoviruses of plant pathogenic fungi can be found in a recent review by Pearson et al [4]. Despite the limited data on mycoviruses of human pathogenic fungi, evidence is provided that mycoviruses do exist in various fungal genera that are pathogenic to humans [6][7][8][9][10][11][12][13][14][15][16][17][18]. The mycoviruses that are associated with fungal genera that can cause human fungal disease and are also formally known by the ICTV are listed in Table 1.…”

Section: Mycovirus Biology and Interaction With The Fungal Hostmentioning

confidence: 99%

Mycoviruses: future therapeutic agents of invasive fungal infections in humans?

Sande

Lo-Ten-Foe

Belkum

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…By Rokuo UsHIYAMA, * * ) Yukitaka NAKAI, * * > and Masato IKEGAMI* * *> (Communicated by Naohide HIRATSUKA, M. J. A., Oct. 12, 1976) Viruses or Virus-like particles have been demonstrated in various species of fungi and most of them are characterized biochemically to contain double-stranded RNA (ds-RNA) (reviwed by Bozarth, 1972 andby Lemke &Nash, 1974) , although very little is so far known with regard to a single-stranded RNA (ss-RNA) (Tuveson & Peterson, 1972;Kuntzel et al, 1973). In previous works, we have reported that three morphologically distinct sizes of polyhedral viruslike particles with a diameter of approx.…”

Section: Detection O F Doublestranded Rna From Polyhedralmentioning

confidence: 99%