2007
DOI: 10.1016/j.micinf.2007.03.007
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MyD88-dependent activation of dendritic cells and CD4+ T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria

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Cited by 64 publications
(73 citation statements)
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References 30 publications
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“…injection of a low dose of LPS (19). Together, these results suggest that, in addition to TLR9 (12,(17)(18)(19)(20), other MyD88-dependent TLRs are involved in the inflammatory response and pathogenesis of ECM. In this regard, the use of E6446 to treat malaria is highly appropriate.…”
Section: Discussionmentioning
confidence: 75%
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“…injection of a low dose of LPS (19). Together, these results suggest that, in addition to TLR9 (12,(17)(18)(19)(20), other MyD88-dependent TLRs are involved in the inflammatory response and pathogenesis of ECM. In this regard, the use of E6446 to treat malaria is highly appropriate.…”
Section: Discussionmentioning
confidence: 75%
“…4C, Lower). Nucleic acid-sensing TLRs (e.g., TLR9, TLR7) are highly expressed on dendritic cells (DCs) and were shown to be activated by Plasmodium products that play a relevant role in malaria pathogenesis (18,30,31). We thus sought to identify the effect of E6446 on cytokines produced by myeloid CD11c + MHCII + DCs using a flow cytometry (FACS) assay for intracellular cytokine staining.…”
Section: E6446 Prevents Hyperresponsiveness Of Tlrs and Lps-induced Smentioning
confidence: 99%
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“…IFN␥ has been shown not only to increase TLR expression but also to prime cells to LPS responses in a number of experimental infections (27)(28)(29)(30) and has also been pointed as crucial to prime macrophages to release high amounts of TNF upon LPS administration and contribute to LPS induced septic shock (31). We (12) and others (14) have shown that TLR9 accounts for a considerable amount of IFN␥ produced during malaria. Furthermore, production of IL12, a potent IFN␥ inducer, is diminished in BMDCs from TLR9 Ϫ/Ϫ mice upon in vitro stimulation with P. chabaudi iRBCs.…”
Section: Discussionmentioning
confidence: 94%
“…Indeed, there is a growing body of literature that TLRs are central mediators of proinflammatory responses during malaria (11). For example, mice deficient in MyD88, an essential adapter molecule for all of the TLRs except TLR3, displayed impaired synthesis of proinflammatory cytokines and commensurate attenuation of symptoms when infected with different Plasmodium strains (12)(13)(14).…”
mentioning
confidence: 99%