Myelin and Myelination*

Aschner, Michael; Toews, Arrel D.

doi:10.1016/b978-0-08-046884-6.01312-9

Cited by 3 publications

(2 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the SN tissue in WT is very rich in lipids compared to the other tissues in WT. This can be explained by the fact that the myelin in peripheral nerve tissue contains more lipids [27]. In fact, the lipidomic analysis was carried out on the entire tissue, so not only do the cell membranes of all neural cells contribute to the lipid profile, but it is also worth considering the contribution of myelin and lipid rafts, enriched with some lipids such as galactosyl ceramide, sphingomyelin, and cholesterol [28,29].…”

Section: Within-class Comparison Of Lipid Profiles Of Diseased and He...mentioning

confidence: 99%

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Alabed,

Del Grosso,

Bellani

et al. 2023

Biomolecules

View full text Add to dashboard Cite

Krabbe disease is a rare neurodegenerative disease with an autosomal recessive character caused by a mutation in the GALC gene. The mutation leads to an accumulation of psychosine and a subsequent degeneration of oligodendrocytes and Schwann cells. Psychosine is the main biomarker of the disease. The Twitcher mouse is the most commonly used animal model to study Krabbe disease. Although there are many references to this model in the literature, the lipidomic study of nervous system tissues in the Twitcher model has received little attention. This study focuses on the comparison of the lipid profiles of four nervous system tissues (brain, cerebellum, spinal cord, and sciatic nerve) in the Twitcher mouse compared to the wild-type mouse. Altogether, approximately 230 molecular species belonging to 19 lipid classes were annotated and quantified. A comparison at the levels of class, molecular species, and lipid building blocks showed significant differences between the two groups, particularly in the sciatic nerve. The in-depth study of the lipid phenotype made it possible to hypothesize the genes and enzymes involved in the changes. The integration of metabolic data with genetic data may be useful from a systems biology perspective to gain a better understanding of the molecular basis of the disease.

show abstract

Section: Within-class Comparison Of Lipid Profiles Of Diseased and He...mentioning

confidence: 99%

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Alabed,

Del Grosso,

Bellani

et al. 2023

Biomolecules

View full text Add to dashboard Cite

show abstract

“…To perform its insulating function, peripheral nerve myelin is ∼80% lipid as compared to most plasma membranes that are ∼50% lipid. 147 The polyunsaturated fatty acids in the myelin plasma membrane are susceptible targets for lipid peroxidation resulting from agents producing free radicals directly or that increase oxidative stress through other mechanisms. The formation and maintenance of compact myelin is dependent upon a number of membrane-associated proteins and the metabolism of specific lipids present within the lipid bilayers (Figure 8).…”

Section: Vulnerabilities Of Schwann Cells and Myelin To Toxicantsmentioning

confidence: 99%

Toxic Peripheral Neuropathies: Agents and Mechanisms

Valentine¹

2019

Toxicol Pathol

View full text Add to dashboard Cite

Toxic peripheral neuropathies are an important form of acquired polyneuropathy produced by a variety of xenobiotics and different exposure scenarios. Delineating the mechanisms of neurotoxicants and determining the degenerative biological pathways triggered by peripheral neurotoxicants will facilitate the development of sensitive and specific biochemical-based methods for identifying neurotoxicants, designing therapeutic interventions, and developing structure–activity relationships for predicting potential neurotoxicants. This review presents an overview of the general concepts of toxic peripheral neuropathies with the goal of providing insight into why certain agents target the peripheral nervous system and produce their associated lesions. Experimental data and the main hypotheses for the mechanisms of selected agents that produce neuronopathies, axonopathies, or myelinopathies including covalent or noncovalent modifications, compromised energy or protein biosynthesis, and oxidative injury and disruption of ionic gradients across membranes are presented. The relevance of signaling between the main components of peripheral nerve, that is, glia, neuronal perikaryon, and axon, as a target for neurotoxicants and the contribution of active programmed degenerative pathways to the lesions observed in toxic peripheral neuropathies is also discussed.

show abstract

Stressed Astrocytes: Insights on the Pathology of Alexander Disease

Guilfoyle¹

2013

View full text Add to dashboard Cite

Myelin and Myelination*

Cited by 3 publications

References 93 publications

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Untargeted Lipidomic Approach for Studying Different Nervous System Tissues of the Murine Model of Krabbe Disease

Toxic Peripheral Neuropathies: Agents and Mechanisms

Stressed Astrocytes: Insights on the Pathology of Alexander Disease

Contact Info

Product

Resources

About