Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition

Saratov, George A.; Belogurov, Alexey A.; Kudriaeva, Anna A.

doi:10.1016/j.biochi.2024.04.011

Biochimie

2024

DOI: 10.1016/j.biochi.2024.04.011

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Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition

George A. Saratov,

Alexey A. Belogurov,

Anna A. Kudriaeva

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2024

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Is Autophagy a Friend or Foe in SARS-CoV-2 Infection?

Khan,

Ling,

2024

Viruses

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As obligate parasites, viruses need to hijack resources from infected cells to complete their lifecycle. The interaction between the virus and host determines the viral infection process, including viral propagation and the disease’s outcome. Understanding the interaction between the virus and host factors is a basis for unraveling the intricate biological processes in the infected cells and thereby developing more efficient and targeted antivirals. Among the various fundamental virus–host interactions, autophagy plays vital and also complicated roles by directly engaging in the viral lifecycle and functioning as an anti- and/or pro-viral factor. Autophagy thus becomes a promising target against virus infection. Since the COVID-19 pandemic, there has been an accumulation of studies aiming to investigate the roles of autophagy in SARS-CoV-2 infection by using different models and from distinct angles, providing valuable information for systematically and comprehensively dissecting the interplay between autophagy and SARS-CoV-2. In this review, we summarize the advancements in the studies of the interaction between SARS-CoV-2 and autophagy, as well as detailed molecular mechanisms. We also update the current knowledge on the pharmacological strategies used to suppress SARS-CoV-2 replication through remodeling autophagy. These extensive studies on SARS-CoV-2 and autophagy can advance our understanding of virus–autophagy interaction and provide insights into developing efficient antiviral therapeutics by regulating autophagy.

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Is Autophagy a Friend or Foe in SARS-CoV-2 Infection?

Khan,

Ling,

2024

Viruses

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Myelin basic protein antagonizes the SARS-CoV-2 protein ORF3a-induced autophagy inhibition

Cited by 1 publication

References 32 publications

Is Autophagy a Friend or Foe in SARS-CoV-2 Infection?

Is Autophagy a Friend or Foe in SARS-CoV-2 Infection?

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