Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis

Pohl‐Koppe, Annette; Burchett, Sandra; Thiele, Elizabeth A.; Hafler, David A.

doi:10.1016/s0165-5728(98)00125-8

Cited by 83 publications

(49 citation statements)

References 33 publications

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“…The ability of high dose steroids to so quickly abrogate MS symptoms suggests that the acute edema and its subsequent resolution underlie the clinical relapse and remission, respectively. Studies in acute disseminated encephalomyelitis (ADEM) in humans (26) and EAE in rodents (27) suggest that immunologically, acute attacks are self-limited by regulatory T cells.…”

Section: Natural Historymentioning

confidence: 99%

“…However, typical ADEM is seen in pediatric populations and has more of an explosive course associated with alterations in mental status, and a post-viral or postvaccination history is often elicited. This disease is associated with significant responses to myelin proteins, indicated both by T cell and antibody measurements (26,36). It is usually not difficult to distinguish this disease entity from "singular sclerosis," and the laboratory measurement of circulating high affinity antimyelin basic protein antibodies in ADEM but not MS may aid in the diagnosis.…”

Section: Diagnosismentioning

confidence: 99%

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Multiple sclerosis

Hafler¹

2004

J. Clin. Invest.

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315

118

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Section: Natural Historymentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Multiple sclerosis

Hafler¹

2004

J. Clin. Invest.

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315

118

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“…Antibodies to gangliosides such as GM1 and GD1a and myelin basic protein-reactive T-helper 2 cells may be present in some patients with ADEM [65,66]. In the pediatric patients with dystonia and behavioral abnormalities, enzyme-linked immunosorbent assay showed elevated antibasal ganglia antibodies and fluorescent immunohistochemistry revealed specific binding to large striatal neurons; neither finding was present in control patients [18••].…”

Section: Pathogenesismentioning

confidence: 99%

Postinfectious encephalomyelitis

Wingerchuk

2003

Curr Neurol Neurosci Rep

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Postinfectious forms of encephalomyelitis, also termed acute disseminated encephalomyelitis (ADEM), form one of several categories of inflammatory demyelinating disorders of the central nervous system (CNS). Recent large, retrospective case series have refined our understanding of the clinical, laboratory, and neuroimaging characteristics of ADEM. The differences between childhood and adult ADEM, risks of development of multiple sclerosis, and the contributions of recent studies to refining the nosology of CNS demyelinating syndromes are discussed.

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“…2 One study demonstrated a 10-fold greater reactivity of T lymphocytes directed towards myelin basic protein in those with ADEM, compared with normal controls and encephalitis patients. 3 Antimyelin-associated glycoprotein (anti-MAG) and anti-myelin basic protein (anti-MBP) antibodies have been detected in cerebrospinal fluid (CSF). 4 Immunomodulation in the form of steroids, i.v.…”

mentioning

confidence: 99%

“…This is consistent with the presumed T-cell-mediated pathogenesis of autoimmune ADEM. 3 A number of disparate reports support the notion that donor T cells may invade the host CNS, resulting in a spectrum of neurological disease. Cerebral angiitis 10 and a chronic demyelinating polyneuropathy have both been reported in association with chronic systemic GVHD.…”

mentioning

confidence: 99%