Myelin characterization of fetal brain with mono-point estimated T1-maps

Almajeed, Adnan Abd; Adamsbaum, C.; Langevin, François

doi:10.1016/j.mri.2004.01.004

Cited by 17 publications

(20 citation statements)

References 12 publications

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“…Previous research conducted in human fetuses in utero reported T1 values in WM (3) and T2* values in various regions of WM and in the THA (4) to be significantly higher than those measured in the adult brain, with a trend to decrease with fetal age found for the T2* values.…”

Section: Introductionmentioning

confidence: 76%

3D in utero quantification of T2* relaxation times in human fetal brain tissues for age optimized structural and functional MRI

Blazejewska

Seshamani

Mckown

et al. 2016

Magnetic Resonance in Med

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Purpose Maximization of the BOLD fMRI contrast requires TE of the MR sequence to match the T2* value of the tissue of interest, which is expected to be higher in the fetal brain compared to a child or an adult. Methods T2* values of the cortical plate/cortical grey matter tissue in utero in healthy fetuses from mid-gestation onwards (20–36 GW) were measured using 3D T2* maps calculated from 2D dual-echo T2*-w data corrected for between-slice motion and reconstructed in 1.0 mm3 isotropic resolution from a sequence of multiple time points, together with 1.0 mm3 isotropic resolution T2-w structural data. Results Mean T2* relaxation times of the cortical tissue were about two times higher than previously reported in adults. In a supporting single seed analysis experiment default mode and auditory networks appeared better localized and less noisy while using TE=100 ms versus TE=43 ms. The results of the previous study reporting a trend for T2* values to decrease with fetal age were reproduced and extended to include subjects in earlier gestation (20–26 GW) and cortical tissues. Conclusions The first measurement of T2* values in fetal cortical tissues suggested the appropriate TE range for fetal BOLD fMRI protocol optimization to be 130–190 ms.

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Section: Introductionmentioning

confidence: 76%

3D in utero quantification of T2* relaxation times in human fetal brain tissues for age optimized structural and functional MRI

Blazejewska

Seshamani

Mckown

et al. 2016

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…The reason for this is that although the degree of myelination was minimally different in the perirolandic and surrounding gyri, the difference in signal intensity was more conspicuous [21]. As shown in some reports [22,23], water content of the brain tissue decreases markedly with increasing gestational age, causing shortening of T 1 /T 2 relaxation and decreased diffusivity, which lead to high signals on T 1 -weighted image and low signals on T 2 -weighted images. Structural or metabolic/chemical composition of the intra-or extracellular environment of brain tissue may be an additional reason for the different signal intensities among various regions of the developing brain.…”

Section: Discussionmentioning

confidence: 95%

Prominent signal intensity of T1/T2 prolongation in subcortical white matter of the anterior temporal region on conventional screening MRI of late preterm infants with normal development

Wuttikul

Taoka

Akashi

et al. 2008

Magnetic Resonance Imaging

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“…WM:GM volume ratios of the total brain were also calculated three times. For the fetal measurements, native T2-weighted images were used because these images displayed better detail of structure edges than PD-weighted images, which was most likely a function of higher water content in fetal brains (Almajeed et al, 2004). For all dolphins, CSF volumes were not calcu-lated because these measurements were most likely inaccurate due to postmortem leakage.…”

Section: Segmentation Analysismentioning

confidence: 99%

Volumetric Neuroimaging of the Atlantic White‐Sided Dolphin (Lagenorhynchus acutus) Brain from in situ Magnetic Resonance Images

Montie

Schneider

Ketten

et al. 2008

The Anatomical Record

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The structure and development of the brain are extremely difficult to study in free-ranging marine mammals. Here, we report measurements of total white matter (WM), total gray matter (GM), cerebellum (WM and GM), hippocampus, and corpus callosum made from magnetic resonance (MR) images of fresh, postmortem brains of the Atlantic white-sided dolphin (Lagenorhynchus acutus) imaged in situ (i.e., the brain intact within the skull, with the head still attached to the body). WM:GM volume ratios of the entire brain increased from fetus to adult, illustrating the increase in myelination during ontogeny. The cerebellum (WM and GM combined) of subadult and adult dolphins ranged from 13.8 to 15.0% of total brain size, much larger than that of primates. The corpus callosum mid-sagittal area to brain mass ratios (CCA/BM) ranged from 0.088 to 0.137, smaller than in most mammals. Dolphin hippocampal volumes were smaller than those of carnivores, ungulates, and humans, consistent with previous qualitative results assessed from histological studies of the bottlenose dolphin brain. These quantitative measurements of white matter, gray matter, corpus callosum, and hippocampus are the first to be determined from MR images for any cetacean species. We establish here an approach for accurately determining the size of brain structures from in situ MR images of stranded, dead dolphins. This approach can be used not only for comparative and developmental studies of marine mammal brains but also for investigation of the potential impacts of natural and anthropogenic chemicals on neurodevelopment and neuroanatomy in exposed marine mammal populations.

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Myelin characterization of fetal brain with mono-point estimated T1-maps

Cited by 17 publications

References 12 publications

3D in utero quantification of T2* relaxation times in human fetal brain tissues for age optimized structural and functional MRI

3D in utero quantification of T2* relaxation times in human fetal brain tissues for age optimized structural and functional MRI

Prominent signal intensity of T1/T2 prolongation in subcortical white matter of the anterior temporal region on conventional screening MRI of late preterm infants with normal development

Volumetric Neuroimaging of the Atlantic White‐Sided Dolphin (Lagenorhynchus acutus) Brain from in situ Magnetic Resonance Images

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