Myelin-like structures in heart muscle cells after administration of adrenalin

Kleimenova, N. N.; Belen'kiĭ, E E

doi:10.1007/bf00835193

Cited by 1 publication

(1 citation statement)

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“…2B) are abundant in O. kimflemingiae-infected muscle. The appearance of myelin-like structures occurs in rat heart muscle following administration of adrenalin (Kleimenova and Belen'kii, 1975), suggesting that these bodies form in response to hypercontraction. Together, the data presented in the present study detailing z-line swelling, sarcomere shortening and disruption, sarcolemma blebbing and the formation of myelin-like bodies in infected muscle (Fig.…”

Section: Discussionmentioning

confidence: 99%

Zombie ant death grip due to hypercontracted mandibular muscles

Mangold

Ishler

Loreto

et al. 2019

Journal of Experimental Biology

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There are numerous examples of parasites that manipulate the behavior of the hosts that they infect. One such host-pathogen relationship occurs between the 'zombie-ant fungus' Ophiocordyceps unilateralis sensu lato and its carpenter ant host. Infected ants climb to elevated locations and bite onto vegetation where they remain permanently affixed well after death. The mandibular muscles, but not the brain, of infected ants are extensively colonized by the fungus. We sought to investigate the mechanisms by which O. unilateralis s.l. may be able to influence mandibular muscle contraction despite widespread muscle damage. We found that infected muscles show evidence of hypercontraction. Despite the extensive colonization, both motor neurons and neuromuscular junctions appear to be maintained. Infection results in sarcolemmal damage, but this is not specific to the death grip. We found evidence of precise penetration of muscles by fungal structures and the presence of extracellular vesicle-like particles, both of which may contribute to mandibular hypercontraction.

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Section: Discussionmentioning

confidence: 99%