Myelin oligodendrocyte glycoprotein-IgG associated disorders (MOGAD) following SARS-CoV-2 infection: A case series

Lambe, Jeffrey; McGinley, Marisa; Moss, Brandon P; Mao-Draayer, Yang; Kassa, Roman M.; Ciotti, John R.; Mariotto, Sara; Kunchok, Amy

doi:10.1016/j.jneuroim.2022.577933

Cited by 19 publications

(15 citation statements)

References 10 publications

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“…Латентный период от момента постановки диагноза коронавирусной инфекции до развития неврологических симптомов составлял от нескольких дней до нескольких недель. Характерными были благоприятный прогноз и отсутствие клинико-радиологических рецидивов в ходе динамического наблюдения в срок до 2 месяцев [12].…”

Section: Discussionunclassified

COVID-19 Associated Serous Meningitis and Optic Neuritis: A Case Report

Чечик¹,

Лихачев²,

Каплич³

et al. 2023

Неврология И Нейрохирургия. Восточная Европа

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В настоящее время описаны различные варианты поражений нервной системы, ассоциированные с коронавирусной инфекцией COVID-19. Особое внимание уделяется таким остро развивающимся заболеваниям, как менингоэнцефалиты, инсульты, судорожные припадки, моно- и полиневропатии, энцефалопатии. Несмотря на имеющееся на текущий момент большое количество публикаций, данная проблема требует дальнейшего тщательного изучения, что связано с необходимостью систематизации данных, выявления новых патогенетических механизмов и разработки оптимальных терапевтических подходов. Огромный интерес также вызывает возможность возникновения у 1 пациента нескольких вариантов острого поражения структур центральной и периферической нервной системы. В статье представлено описание собственного клинического наблюдения пациента, у которого развились серозный менингит и оптический неврит, ассоциированные с коронавирусной инфекцией COVID-19. На примере клинического наблюдения рассмотрены особенности течения заболевания, подходы к диагностике и лечению, а также возможные сложности в процессе дифференциально-диагностического поиска. Nowadays, a variety of nervous system lesions associated with COVID-19 infection has been described. A special attention is paid to such acute developing diseases as meningoencephalitis, strokes, seizures, mono- and polyneuropathy, and encephalopathy. Despite the large number of available publications, this issue requires further careful study due to the necessity of systematizing data, identifying new pathogenetic mechanisms, and developing optimal therapeutic approaches. The possibility of several variants of acute damage to the structures of the central and peripheral nervous system in the same patient is also of great interest. The article describes the own clinical observation of a patient who developed serous meningitis and optic neuritis associated with COVID-19 infection. The clinical features of the disease course and approaches to diagnosis, as well as possible difficulties in the differential diagnostic process are considered.

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Section: Discussionunclassified

COVID-19 Associated Serous Meningitis and Optic Neuritis: A Case Report

Чечик¹,

Лихачев²,

Каплич³

et al. 2023

Неврология И Нейрохирургия. Восточная Европа

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“…Several authors described MOGAD after SARS-CoV-2 infection. 9 – 12 Sawalha et al 13 report a case of a 44-year-old Hispanic male patient presented with bilateral eye pain and vision loss. Two weeks prior the onset of symptoms, he had tested positive for SARS-CoV-2 disease.…”

Section: Discussionmentioning

confidence: 99%

MOG-IgG positive optic neuritis after SARS-CoV-2 infection

Gilardi

Cortese

Ferraro

et al. 2022

European Journal of Ophthalmology

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Background Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG. Objective To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger. Methods Retrospective single case report. Results We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection. Conclusion This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.

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“…26 Case series of MOG associated optic neuritis in COVID-19 suggest it presents very similarly to non-COVID-19 MOG optic neuritis: generally occurs 2-4 weeks post infection, presents with reduced visual acuity with retro-orbital pain and pain on eye movements, demonstrates involvement of the anterior aspect of the optic nerve often with perineural enhancement on MR imaging, and responds well to corticosteroids. [26][27][28] However, so far in the reported literature all cases have been monophasic which is not the case in non-COVID-19 MOG optic neuritis. 28 Despite a specific auto-antibody directed against the MOG protein it is unlikely that this represents a form of molecular mimicry with the proteins found on the COVID-19 virus as there is no homology between the MOG protein and viral proteins.…”

Section: Immune Mediated Disordersmentioning

confidence: 96%

“…[26][27][28] However, so far in the reported literature all cases have been monophasic which is not the case in non-COVID-19 MOG optic neuritis. 28 Despite a specific auto-antibody directed against the MOG protein it is unlikely that this represents a form of molecular mimicry with the proteins found on the COVID-19 virus as there is no homology between the MOG protein and viral proteins. 27 It is more likely to occur due to loss of self-tolerance in an activated adaptive immune system.…”

Section: Immune Mediated Disordersmentioning

confidence: 96%

“…Case series of MOG associated optic neuritis in COVID‐19 suggest it presents very similarly to non‐COVID‐19 MOG optic neuritis: generally occurs 2–4 weeks post infection, presents with reduced visual acuity with retro‐orbital pain and pain on eye movements, demonstrates involvement of the anterior aspect of the optic nerve often with perineural enhancement on MR imaging, and responds well to corticosteroids 26–28 . However, so far in the reported literature all cases have been monophasic which is not the case in non‐COVID‐19 MOG optic neuritis 28 . Despite a specific auto‐antibody directed against the MOG protein it is unlikely that this represents a form of molecular mimicry with the proteins found on the COVID‐19 virus as there is no homology between the MOG protein and viral proteins 27 .…”

Section: Potential Pathogenesis Of Covid‐19 Related Neurological Comp...mentioning

confidence: 99%

See 1 more Smart Citation

An eye to the future: Acute and long‐term neuro‐ophthalmological and neurological complications of COVID‐19

Wesselingh

2023

Clinical Exper Ophthalmology

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COVID‐19 has had a significant impact on the global population and has produced compelling evidence of non‐pulmonary organ dysfunction, including the nervous system. It is vital that specialists in ophthalmology and neurology are informed of the potential complications of COVID‐19 and gain a deeper understanding of how COVID‐19 can cause diseases of the nervous system. In this review we detail four possible mechanisms by which COVID‐19 infection may result in neurological or neuro‐ophthalmological complications: (1) Toxic and metabolic effects of severe pulmonary COVID‐19 disease on the neural axis including hypoxia and the systemic hyper‐inflammatory state, (2) endothelial dysfunction, (3) dysimmune responses directed again the neuroaxis, and (4) direct neuro‐invasion and injury by the virus itself. We explore the pathological evidence for each of these and how they may link to neuro‐ophthalmological disorders. Finally, we explore the evidence for long‐term neurological and neuro‐ophthalmological complications of COVID‐19, with a focus on neurodegeneration.

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Myelin oligodendrocyte glycoprotein-IgG associated disorders (MOGAD) following SARS-CoV-2 infection: A case series

Cited by 19 publications

References 10 publications

COVID-19 Associated Serous Meningitis and Optic Neuritis: A Case Report

COVID-19 Associated Serous Meningitis and Optic Neuritis: A Case Report

MOG-IgG positive optic neuritis after SARS-CoV-2 infection

An eye to the future: Acute and long‐term neuro‐ophthalmological and neurological complications of COVID‐19

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