Myeloblastic leukaemia in a Morgan horse mare

Clark, P.; Cornelisse, C.J.; Schott, H. C.; Swenson, Cheryl L.; Bell, Thomas G.

doi:10.1111/j.2042-3306.1999.tb03847.x

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…Myeloproliferative disease is rarely reported in horses; there have been less than 20 reported cases in the past 30 years. Forms of myeloproliferative disease previously described in horses include myeloblastic leukaemia, 1,2 chronic granulocytic leukaemia, 3–5 myelomonocytic leukaemia, 6–12 monocytic leukaemia 13,14 and eosinophilic myeloproliferative disorder 15 . No age predilection is apparent.…”

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confidence: 99%

Acute myeloid leukaemia (M6B: pure acute erythroid leukaemia) in a Thoroughbred foal

et al. 2011

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A 10-week-old Thoroughbred filly was referred for anaemia of 4 weeks' duration. Haematology revealed severe anaemia and panleucopenia. Cytological examination of bone marrow smears revealed a myeloid to erythroid ratio <0.02:1 (reference range 0.5-2.4:1.0) and an abundance of erythroid precursor cells. The erythroid cell population included rubriblasts, prorubricytes and rubricytes, with only scant numbers of metarubricytes present. There were numerous mitotic erythroid cells, some of which were atypical and megaloblastic. These cytomorphological changes are consistent with pure acute erythroid leukaemia. No treatment was instituted and the filly died three days after presentation. This case illustrates the need to consider both haematology and bone marrow findings to establish a diagnosis of pure erythroid leukaemia. To our knowledge, there is no documented case of acute myeloproliferative disease in horses involving cells of erythroid lineage, but this condition should be considered a differential diagnosis for horses presenting with anaemia.

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confidence: 99%

Acute myeloid leukaemia (M6B: pure acute erythroid leukaemia) in a Thoroughbred foal

et al. 2011

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“…A review of the literature revealed 2 cases of AML and 1 case of chronic myelogenous leukemia (CML) in horses. [3][4][5] Differentiation of chronic leukemia (myelogenous or lymphocytic) and leukemoid reaction due to inflammation is often challenging. The low number of atypical cells in the peripheral blood in CGL makes the diagnosis less confident based only on CBC.…”

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confidence: 99%

“…Marked thrombocytopenia has also been a feature of previously reported cases of granulocytic leukemia. [3][4][5] A lack of megakaryocytes in the bone marrow indicated that platelet production was impeded by the marked myelogenous proliferation. Furthermore, this horse had profound hypoalbuminemia.…”

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Chronic Granulocytic Leukemia in a Horse

Johansson

Skidell

Lilliehöök

et al. 2007

Veterinary Internal Medicne

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“…Differentiation between primary lymphoid leukemia and the leukemic phase of a lymphoma can be achieved with the finding of solid tumors in lymphoma cases. Most cases of lymphoid leukemia are secondary to a lymphoma and only a few cases of primary LL have been reported in horses (Roberts, 1977;Ringger et al, 1997;Clark et al, 1999). No solid tumor was found during clinical and gross examination in this case.…”

Section: Discussionmentioning

confidence: 79%

Acute B-lymphoid leukemia in a mare: a case report

Bezděková¹,

Faldyna²,

Zapletal³

et al. 2009

Vet. Med. - Czech

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An 8-year-old Friesen mare was admitted to the Equine Clinic, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic with ventral edema and weight loss which had proceeded over the course of a few weeks. Clinical examination revealed poor body condition, depression, weakness, pale mucous membranes, enlarged mandibular lymph nodes and ventral edema. Thoracic percussion revealed fluid level reaching the shoulder on both sides. CBC revealed a severe disproportion of red and white cells. The horse was anemic and there was leucocytosis with the majority being blast cells (leucocyte concentration was 450.4 × 10 9 /l) which included mitotic figures. The serum chemistry profile revealed hypoalbuminemia and increased alkaline phosphatase bone isoenzyme (BALP was 784.3 µkat/l). Based on the number of precursors in the peripheral blood acute leukemia was diagnosed. The peripheral blood was examined by flow cytometry and cytochemistry. The final diagnosis was determined as acute B cell lymphoid leukemia. The mare was treated with corticosteroids. On the second day of treatment the white blood cell count and alkaline phosphatase level decreased. The improvement continued until the fifth day, when the mare's status deteriorated and the horse was euthanized. Gross examination was carried out but no neoplastic mass was discovered. Final differentiation between primary and secondary lymphoid leukemia was not possible in this case.

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Myeloblastic leukaemia in a Morgan horse mare

Cited by 18 publications

References 8 publications

Acute myeloid leukaemia (M6B: pure acute erythroid leukaemia) in a Thoroughbred foal

Acute myeloid leukaemia (M6B: pure acute erythroid leukaemia) in a Thoroughbred foal

Chronic Granulocytic Leukemia in a Horse

Acute B-lymphoid leukemia in a mare: a case report

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