Myelofibrosis in Chronic Granulocytic Leukaemia

Clough, V.; Geary, C. G.; Hashmi, Khalid Zafar; Davson, J.; T, Knowlson

doi:10.1111/j.1365-2141.1979.tb01164.x

Cited by 68 publications

(23 citation statements)

References 24 publications

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“…[1][2][3][4][5][6] Whether MF provides prognostic information independent of other significant prognostic factors is discussed controversially. 3,[7][8][9] Recently, an independent poor prognostic significance has been detected on basis of a prospective controlled trial.…”

Section: Introductionmentioning

confidence: 99%

Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia

et al. 2004

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“…Although some early reports pointed to the possible prognostic value of marrow histology in CGL [7][8][9][10], studies in this field have been scarce and limited to the prognostic evaluation of marrow fibrosis [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…The development of marrow fibrosis has been ac cepted as a poor prognostic factor [7][8][9][10], but its unfa vorable prognostic influence at diagnosis has only re cently been extensively analyzed [12,13]. Gralnick et al [7] evaluated 181 patients, in 39 of whom myelofi brosis was demonstrated during the course of the dis ease.…”

Section: Discussionmentioning

confidence: 99%

“…Several workers have pointed out myelofibrosis as a poor prognostic feature in CGL, chiefly when it ap pears during the course of the disease, whereas its sig nificance at diagnosis has been less extensively evalu ated [7][8][9][10][11][12][13], However, the prognostic significance of other initial bone marrow biopsy features in CGL has not been analyzed.…”

Section: Introductionmentioning

confidence: 99%

“…These attempts at prognostic classification have been based on the use of several clinical and biological fea tures. However, although some data exist in the litera ture suggesting a prognostic value of marrow biopsy in CGL [7][8][9][10][11][12][13], bone marrow histopathological chan ges have not been included in such analyses.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Evaluation of Initial Bone Marrow Histopathological Features in Chronic Granulocytic Leukemia

Cervantes¹,

Rozmán²,

Feliú³

1989

Acta Haematol

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In 100 patients with nonblastic Ph¹-positive chronic granulocytic leukemia (CGL) the main features from the initial bone marrow biopsy were correlated with other clinical and hematological parameters and analyzed for prognostic significance. The mean number ( ± SD) of megakaryocytes per square millimeter of marrow tissue was 25.9 ± 18.8. Marked reticulin fibrosis was observed in 19% of the patients but in only 5 cases it was diffuse, whereas collagen deposition was found in 10. patients. Reticulin fibrosis correlated significantly with white blood cell count and peripheral blood blast cell percentage, but not with platelet count. Actuarial survival studies demonstrated that marked diffuse reticulin fibrosis (p = 0.0005) and more than 15 megakaryocytes/mm3 of marrow tissue (p = 0.01) were associated with a poorer prognosis. However, they lost their prognostic influence when included in a multivariate regression model together with the patients’ relative risk according to the currently most widely accepted CGL prognostic system. Such results indicate that bone marrow biopsy features add little prognostic weight to known prognostic indicators in CGL.

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The relevance of reticulin stain-measured fibrosis at diagnosis in chronic myelogenous leukemia

Dekmezian

Kantarjian

Keating

et al. 1987

Cancer

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Although collagen myelofibrosis indicates poor prognosis in late stages of chronic myelogenous leukemia, the significance of reticulin stain-measured fibrosis in newly diagnosed patients is unknown. One hundred and thirty-eight patients with untreated or minimally treated chronic phase Philadelphia chromosome-positive chronic myelogenous leukemia had reticulin stain studies made on their bone marrows at diagnosis. Reticulin fibrosis was graded on a scale of 1 to 4. Significant (Grade 3 or 4) fibrosis was noted in 65 patients (47%). Compared with patients with mild (Grade 1 to 2) reticulin fibrosis, those with significant fibrosis had a higher incidence of splenomegaly greater than or equal to 10 cm (29% versus 49%; P = 0.02), hemoglobin less than 10 g/dl (19% versus 49%; P less than 0.01), weight loss greater than or equal to 6.75 kg (10% versus 30%; P = 0.11), marrow blasts greater than or equal to 5% (7% versus 28%; P less than 0.01), peripheral blasts greater than or equal to 3% (30% versus 46%; P = 0.09), and additional karyotypic abnormalities (1% versus 17%; P less than 0.01). The incidence of thrombocytosis was similar in the two groups. Prognostically, median survival was significantly shorter for the 26 patients with Grade 4, compared with the 39 patients with Grade 3, and the 73 patients with Grade 1 or 2 reticulin fibrosis (32 versus 49 versus 57 months; P = 0.03). Reticulin fibrosis is a useful biologic and prognostic index in newly diagnosed patients with chronic phase chronic myelogenous leukemia.

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Myelofibrosis in Chronic Granulocytic Leukaemia

Cited by 68 publications

References 24 publications

Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia

Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia

Prognostic Evaluation of Initial Bone Marrow Histopathological Features in Chronic Granulocytic Leukemia

The relevance of reticulin stain-measured fibrosis at diagnosis in chronic myelogenous leukemia

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