Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

Abstract

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins. Many of them are expressed in myeloid cells and signal in response to pathogen-derived or self ligands to initiate or regulate cell activation. Here, we review the properties of myeloid CLRs, highlighting how their signaling function is coordinated with that of other innate receptor families to control immunity to infection.

Proteomic Cornerstones of Hematopoietic Stem Cell Differentiation: Distinct Signatures of Multipotent Progenitors and Myeloid Committed Cells

“…Such proteases serve for bacterial killing in specialized lysosomal granules and are known to be specifically expressed in early myeloid progenitors (61). Further, C-type lectins (Clec10a, Clec12a), which are involved in sensing of bacterial carbohydrates (62) and their downstream mediator Card9 (63) were pronounced in the myeloid compartment. Notably, numerous ER stress response proteins that participate in unfolded protein response and immunomodulatory functions (e.g.…”

Pattern Recognition Receptors and Infectious Diseases

“…The mechanism of activation and signalling cascades involved in this process are highly complex and contain a significant level of overlap, redundancy and cross-talk. A more comprehensive discussion of these processes can be found in a variety of excellent review articles and the references they contain (Davis et al, 2011;Kawai and Akira, 2011;Loo and Gale, 2011;Osorio and Reis e Sousa, 2011).In the following sections we will see that although pathogens usually activate a number of PRRs, they have adapted their modes of attack so as to bypass the innate immune system, and hence be able to colonise the body.…”

Pattern Recognition Receptors and Cancer: Is There Any Role of Inherited Variation?

“…The summary of the most modern conceptual data about members of these families and about their structure and functions can be obtained from the recent comprehensive reviews (Elinav et al, 2011;Kawai and Akira, 2011;Osorio and Reis E Sousa, 2011;Loo and Gale, 2011), and the schemes of their signaling are presented in Figures 1-2. Fig.…”