Myeloid Cell HO-ming in AKI

Abstract

Human monocyte-derived macrophages spontaneously differentiated in vitro show distinct phenotypes. J Cell Physiol 228: 1464-1472, 2013 18. Polak ME, Thirdborough SM, Ung CY, Elliott T, Healy E, Freeman TC, Ardern-Jones MR: Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation.

Heme Oxygenase-1 Gene Polymorphisms—Toward Precision Medicine for AKI

“…HO-1 has been a subject of key reviews and editorials, with several focusing on its importance in the kidney. 1,[3][4][5] In this issue of the Journal of the American Society of Nephrology, Leaf et al 6 highlight the importance of an association between genetic polymorphisms in the HO-1 promoter and the risk for developing AKI after major cardiac surgery. The polymorphism pertains to variations in length in a GTrepeat region in the proximal promoter of the human HO-1 gene, which typically ranges between 12 and 40.…”

“…1 Although the causes of graft (and patient) loss are often complex and multifactorial, it has been increasingly recognized that antibodymediated (humoral) immune responses play an important role in kidney transplant failures. [2][3][4] Antibody-mediated allograft injury represents a continuum of damage, ranging from hyper-acute rejection to acute antibody-mediated rejection (AMR) to chronic antibody-mediated rejection (cAMR). These manifestations can develop in patients with preexisting donor-specific antibody (DSA) or in patients who develop de novo DSA, and the antibody-mediated damage adversely affects allograft survival.…”