2024
DOI: 10.1101/2024.05.02.590528
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Myeloid cell networks determine reinstatement of original immune environments in recurrent ovarian cancer

Eleonora Ghisoni,
Fabrizio Benedetti,
Aspram Minasyan
et al.

Abstract: Immunotherapy has produced disappointing results in recurrent ovarian cancer (OC). However, the prognostic value of tumour-infiltrating lymphocytes (TILs) is largely based on the analysis of treatment-naive tumours. To understand the immunobiology of recurrent cancers, and their evolution, we profiled 170 patient-matched primary-recurrent OC samples from 69 patients of two independent cohorts. By capturing heterogeneous TIL distributions, we identified four immune phenotypes associated with differential progno… Show more

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