Myeloid-Derived Suppressor Cells in Some Oncohematological Diseases

Пономарев, А. В.

doi:10.21320/2500-2139-2017-10-1-29-38

Cited by 2 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Эти клетки представляют собой патологическое состояние активации моноцитов и относительно незрелых нейтрофилов. Характерная особенность MDSC -их способность ингибировать функции Т-клеток, что может способствовать патогенезу различных заболеваний [1], в том числе и онкогематологических [2]. Моноцитарные MDSC имеют фенотип CD14 + HLA-DR low / - [1].…”

Section: Introductionunclassified

“…Моноцитарные MDSC имеют фенотип CD14 + HLA-DR low / - [1]. Данные клетки показывают положительную корреляцию их количества в периферической крови с опухолевой нагрузкой и стадией заболевания при В-клеточном хроническом лимфоцитарном лейкозе (В-ХЛЛ) [2].…”

Section: Introductionunclassified

See 1 more Smart Citation

EFFECT OF HLA-DR ANTIBODY CONCENTRATION ON ESTIMATION OF THE NUMBER OF CD14+HLA-DRLOW /–-CELLS IN THE BLOOD OF PATIENTS WITH B-CELL chronic lymphocytic leukemia

Пономарев

Мисюрин

Барышникова

2020

Rossijskij bioterapevtičeskij žurnal

View full text Add to dashboard Cite

Introduction. Immunoregulatory functions of myeloid-derived suppressor cells have been extensively studied over the recent decades. Additionally, myeloid-derived suppressor cells have been investigated as a prognostic factor.Objective. To optimize the measurement of monocytic myeloid-derived suppressor cells in the peripheral blood of patients with B-cell chronic lymphocytic leukemia.Materials and methods. The number of myeloid-derived suppressor cells with CD14+HLA-DRlow/–-phenotype was determined in the peripheral blood of patients with B-cell chronic lymphocytic leukemia and healthy donors by flow cytometry. The measurement was carried out at two points, which differed in the concentration of anti-HLA-DR antibodies − 15 and 4 μl.Results. The median amount of myeloid-derived suppressor cells in the peripheral blood of B-cell chronic lymphocytic leukemia patients with 15 μl of anti-HLA-DR antibody was 1.9 %, and with 4 μl of antibody concentration – 7 %. Healthy donors had that median of 0.15 % with 15 μl of antibody and 0.3 % with 4 μl concentration.Conclusion. The number of CD14+HLA-DRlow/–-cells in the blood of patients with B-cell chronic lymphocytic leukemia is sensitive to the concentration of the HLA-DR antibody.Compliance with patient rights and principles of bioethics. The study protocol No 3 of 13.02.2020 was approved by the biomedical ethics committee of Research Institute of Experimental Diagnostics and Therapy of Tumors N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation. All patients gave written informed consent to participate in the study.

show abstract

Section: Introductionunclassified

EFFECT OF HLA-DR ANTIBODY CONCENTRATION ON ESTIMATION OF THE NUMBER OF CD14+HLA-DRLOW /–-CELLS IN THE BLOOD OF PATIENTS WITH B-CELL chronic lymphocytic leukemia

Пономарев

Мисюрин

Барышникова

2020

Rossijskij bioterapevtičeskij žurnal

View full text Add to dashboard Cite

show abstract

Insights Into Mechanisms of Tumor and Immune System Interaction: Association With Wound Healing

Пономарев¹,

Шубина²

2019

Front. Oncol.

View full text Add to dashboard Cite

A large number of studies have presented a great deal of information about tumor and immune system interaction. Nevertheless, the problem of tumor evasion from the immune reaction is still difficult to resolve. Understanding the ways in which immunosuppressive tumor microenvironment develops and maintains its potential is of utmost importance to ensure the best use of the suppressed immune functions. The study presents a review covering the data on tumor-associated antigens, mechanisms of tumor evasion from the immune reactions, and search for common immunosuppressive processes of tumor growth and normal wound healing. The study discusses the important role of monocytes/macrophages in the regulation of immune system reactions. We suggest that the simultaneous actions of growth factors and pro-inflammatory cytokines may result in the suppression of the immune system. The study describes intracellular signaling molecules that take part in the regulation of the myeloid cell functions. If the hypothesis is proved correct, the indicated interaction of cytokines could be regarded as a prospective target for antitumor therapy.

show abstract

Myeloid-Derived Suppressor Cells in Some Oncohematological Diseases

Cited by 2 publications

References 79 publications

EFFECT OF HLA-DR ANTIBODY CONCENTRATION ON ESTIMATION OF THE NUMBER OF CD14<sup>+</sup>HLA-DR<sup>LOW /–</sup>-CELLS IN THE BLOOD OF PATIENTS WITH B-CELL chronic lymphocytic leukemia

EFFECT OF HLA-DR ANTIBODY CONCENTRATION ON ESTIMATION OF THE NUMBER OF CD14<sup>+</sup>HLA-DR<sup>LOW /–</sup>-CELLS IN THE BLOOD OF PATIENTS WITH B-CELL chronic lymphocytic leukemia

Insights Into Mechanisms of Tumor and Immune System Interaction: Association With Wound Healing

Contact Info

Product

Resources

About