Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Abstract

Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation of immune responses in many pathological conditions and are closely associated with poor clinical outcomes in cancer. Recent studies have indicated key distinctions between MDSCs and classical neutrophils and monocytes, and, in this Review, we discuss new data on the major genomic and metabolic characteristics of MDSCs. We explain how these characteristics shape MDSC function and could facilitate therapeutic targeting of these cells, particularly in cancer and in autoimmune diseases. Additionally, we briefly discuss emerging data on MDSC involvement in pregnancy, neonatal biology and COVID-19.

Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

“…Our results show that ASC can induce features of PMN-MDSC in mature neutrophils: low density, increased LOX-1 expression, and T-cell suppressor function. These results are consistent with the growing understanding of granulocyte diversity in the TME (50,51), and the notion of granulocyte subsets acquiring suppressor function through distinct pathways that include abnormal granulopoiesis (bona fide PMN-MDSC) and signaling pathways induced in the TME that render normal mature neutrophils suppressive.…”

CD244+ polymorphonuclear myeloid‑derived suppressor cells reflect the status of peritoneal dissemination in a colon cancer mouse model

“…The findings in this study are also consistent with those of previous studies that have analyzed the clinical samples derived from patients with gastric cancer (31), cervical cancer (32), and breast cancer (33). In addition, human cancers have extremely high heterogeneity, by which MDSCs can be induced through a wide variety of tumor-relevant mechanisms (34). Based on these findings, we believe that the findings in this study can be generalized at least to some extent.…”

Multi-Omics Perspective Reveals the Different Patterns of Tumor Immune Microenvironment Based on Programmed Death Ligand 1 (PD-L1) Expression and Predictor of Responses to Immune Checkpoint Blockade across Pan-Cancer

“…To compare the difference in the proportion of T cell exhaustion and MDSCs between four TIME subtypes, we used the gene set obtained for previous studies [ 69 , 70 ] to calculate the GSVA score across four subtypes.…”