Myeloid marker expression on antiviral CD8⁺ T cells following an acute virus infection

Abstract

CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or macrophage populations. In this study, the expression of all three markers was observed on CD8 + T cells following infection of mice with several distinct viruses. Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b + CD8 + and CD11c + CD8 + T cells were present in the periphery than in primary lymphoid organs; in contrast, the F4/ 80 + CD8 + T cell population was more prevalent in the spleen. All three myeloid markers were detected on virus-specific CTL. The expression of CD11b and CD11c on CD8 + T cells correlated with their level of CTL activity, whereas the F4/80 + CD8 + T cell population increased after the peak of the CTL response but did not have higher CTL activity. These data suggest that there is a differential induction of CD11b, CD11c, and F4/80 on virus-specific CD8 + T cells following an acute virus infection.

Differential use of autophagy by primary dendritic cells specialized in cross-presentation

“…S2B). Therefore, this suggests the impaired CTL generation following immunization of Atg7-DC CKO mice most likely results from deletion of Atg7 in CD8 C T cells, that can express CD11c when activated, 41 rather than a true requirement for autophagy in DC-mediated cross-presentation of cell-associated antigen.…”

p150/95 (CD11c/CD18) Expression Is Required for the Development of Experimental Autoimmune Encephalomyelitis

“…Nevertheless, our results provide strong indirect evidence suggesting that p150/95 may be important for cellular trafficking into the CNS. p150/95 expression increases on activated B and T cells, particularly cytotoxic T cells, the latter of which suggests a role in adhesive events leading to target cell killing [15][16][17]32,35 These studies also raise the possibility that p150/95 contributes to the development and or stability of the immunological synapse along with LFA-1. The absence of p150/95 on either T cells or antigen-presenting cells (APCs) could result in reduced T-cell activation and an altered pattern of cytokine production, a finding we obtained with CD11c Ϫ/Ϫ mice in EAE ( Figure 6).…”

Evaluation of Immunological Paradigms in a Virus Model: Are Dendritic Cells Critical for Antiviral Immunity and Viral Clearance?

“…In contrast, depletion of DC profoundly suppressed clonal expansion of tetramer ϩ cells in both lymphoid and nonlymphoid compartments. Inhibition of the proliferative response reflected ablation of DCs and not toxicity of DT for activated CD11c ϩ T cells (10,43,44). Thus, DT treatment administered at a time when DCs were no longer required for T cell activation, failed to inhibit clonal expansion.…”

“…A potential complication in the interpretation of our data is expression of CD11c on activated T cells (10,43,44). Thus, inhibition of T cell clonal expansion by DT may reflect ablation of activated CD11c ϩ T cells and not DCs.…”