2014
DOI: 10.1002/art.38369
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Myeloid‐Related Proteins 8 and 14 Contribute to Monosodium Urate Monohydrate Crystal–Induced Inflammation in Gout

Abstract: Objective. Monosodium urate monohydrate (MSU) crystal-induced interleukin-1␤ (IL-1␤Monosodium urate monohydrate (MSU) crystalinduced arthritis, or gout, is the most common inflammatory arthritis and is characterized by recurrent selflimiting attacks of acute joint inflammation (1). The inflammatory phase is associated with the release of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-1␤, and tumor necrosis factor ␣ (TNF␣), and with the infiltration of leukocytes (2-5). In the last couple of years … Show more

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Cited by 59 publications
(38 citation statements)
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“…In pDC, supernatant from lcSSc S100A8/A9 is specifically increased (145.4±30.5) compared with that of pDCs from dSSc patients (32.2±5.8 (dcSSc); p<0.0001) and their healthy counterparts (35.4±8.7; p=0.0003) (figure 1B). S100A8/A9 was markedly higher in serum of SSc patients (530±32) compared with the known cut-off level (mean+2 times SD) of 480 historical healthy controls 13 14. A second replication cohort, comprising 20 SSc patients and 20 controls, confirmed this observation of increased levels of S100A8/A9 in SSc (p=0.009) .…”
Section: Resultsmentioning
confidence: 58%
“…In pDC, supernatant from lcSSc S100A8/A9 is specifically increased (145.4±30.5) compared with that of pDCs from dSSc patients (32.2±5.8 (dcSSc); p<0.0001) and their healthy counterparts (35.4±8.7; p=0.0003) (figure 1B). S100A8/A9 was markedly higher in serum of SSc patients (530±32) compared with the known cut-off level (mean+2 times SD) of 480 historical healthy controls 13 14. A second replication cohort, comprising 20 SSc patients and 20 controls, confirmed this observation of increased levels of S100A8/A9 in SSc (p=0.009) .…”
Section: Resultsmentioning
confidence: 58%
“…The priming of inflammasome is also a critical step in the process of gouty flare. Interestingly, cytoplasmic S100A8/9 protein heterodimers are highly expressed in neutrophils (Edgeworth et al, 1991) and increase in synovial fluid (Holzinger et al, 2014) and plasma (Ryckman et al, 2003) during a gout flare. Furthermore, S100A8 can activate TLR4 (Vogl et al, 2007) and MSU stimulates the secretion of S100A8/9 from neutrophils (Ryckman et al, 2004).…”
Section: Resultsmentioning
confidence: 99%
“…Pro-inflammatory factors expressed in the gouty tophus include interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α) and myeloid-related proteins-8 and -14 [2][3][4]. Transforming growth factor-β (TGF-β) is also expressed in the tophus [2].…”
Section: Composition Of the Tophusmentioning
confidence: 99%