Myeloid Sarcoma of the Breast Misdiagnosed as Poorly Differentiated Mammary Carcinoma with Lobular Features

Stewart, Rachel L.; Dell, Carol M.; Samayoa, Luis

doi:10.1111/tbj.12377

Cited by 15 publications

(12 citation statements)

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“…However, GS of the breast is often indistinguishable from benign tumors or lymphoma. For example, previous studies have reported patients presenting with an asymptomatic lump (5)(6)(7)(8), while other studies have reported patients presenting with a tender lump (9)(10)(11). Therefore, it is difficult to define typical features of affected patients.…”

Section: Introductionmentioning

confidence: 83%

Granulocytic sarcoma of the breast: A case report

Huang

Zhou

2015

Oncology Letters

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Abstract. Granulocytic sarcoma (GS) is an unusual type of tumor composed of immature cells outside the bone marrow. The disease exhibits a correlation with acute myeloid leukemia and other myeloproliferative disorders. Although it can invade a number of areas of the body, the involvement of the breast is uncommon. The present study reports the case of a 58-year-old female with a mildly tender lump in the left breast that had been apparent for one year. Available diagnostic techniques, including ultrasound, magnetic resonance imaging and mammography, were systematically used to determine a diagnosis of GS, and lumpectomy and systemic chemotherapy were performed. The patient was satisfied with the result of no local recurrence at the one year follow-up examination. The present study discusses the clinical and pathological characteristics of the present case of GC.

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Section: Introductionmentioning

confidence: 83%

Granulocytic sarcoma of the breast: A case report

Huang

Zhou

2015

Oncology Letters

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“…Of all breast leukemias, acute myelogenous leukemia is the most commonly occurring and it presents as myeloid sarcoma [11]. Myeloid sarcoma is an extramedullary hematological malignant tumor of myeloid cells showing varying degrees of maturation, and is most commonly observed in patients with previously diagnosed myeloid leukemia [3,12]. According to the World Health Organization, myeloid sarcomas can be classified into 3 categories: blastic (composed mainly of myeloblasts), immature (composed of myeloblast and promyelocytes), and differentiated (composed of promyelocytes and more mature neutrophils) [13].…”

Section: Discussionmentioning

confidence: 99%

“…The gold standard for the final diagnosis of myeloid sarcoma is histopathological examination combined with immunohistochemical testing [4]. Myeloperoxidase staining is often strongly positive in myeloid sarcoma [3].…”

Section: Discussionmentioning

confidence: 99%

“…Myeloid sarcoma is a rarely observed hematologic malignancy occurring as a soft tissue mass at extramedullary sites [1,2]. Myeloid sarcomas comprise myeloid cells with variable degrees of maturation and usually manifest simultaneously with or subsequently to the diagnosis of myeloid leukemia [3]. Premature cells that are differentiated from hematopoietic precursor cells interact with fibroblasts to induce myeloid metaplasia in nonhematopoietic tissues [4].…”

Section: Introductionmentioning

confidence: 99%

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Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Kim

2019

Am J Case Rep

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Patient: Female, 24 Final Diagnosis: Myeloid sarcoma of the breast Symptoms: Breast lump Medication: — Clinical Procedure: Core needle biopsy Specialty: Radiology Objective: Rare disease Background: Myeloid sarcoma is a rarely observed extramedullary presentation of myeloid leukemia that seldom manifests in the breast. Myeloid sarcoma can occur before, concurrently with, or following acute myeloid leukemia presentation. Few reports have focused on the imaging findings in cases of myeloid sarcoma of the breast, and the existing findings are variable and nonspecific; the present case report aimed to bridge this gap. Case Report: A 24-year-old female presented with a palpable lump at the upper outer quadrant of her right breast. She had noticed the mass 2 days prior to presentation. She was first diagnosed with acute myelogenous leukemia 18 months before the lump presentation and had undergone haploidentical stem cell transplantation 6 months prior. At the time of the breast lump presentation, she was undergoing chemotherapy for relapsed acute myeloid leukemia. Ultrasonography of her right breast revealed a circumscribed, oval mass corresponding to the palpable lump. Ultrasonography-guided 14-gauge core needle biopsy was performed on the breast mass, leading to a pathological diagnosis of myeloid sarcoma. Conclusions: We reported a case of myeloid sarcoma involving the breast. On sonography, although the internal echotexture resembled that of breast hamartoma, the observed hard elasticity and high vascularity raised suspicions of malignancy.

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“…Although MS is an extramedullary hematological malignancy, in which myeloid cells show various degrees of maturation, it is frequently seen in patients with previously diagnosed myeloid leukemia (9,10). According to the World Health Organization, MS is diagnosed based on three classes: blastic (consisting of myeloblasts), immature (consisting of myeloblasts and promyelocytes), and differentiated (consisting of promyelocytes and more mature neutrophils) (8).…”

Section: Discusson and Conclusionmentioning

confidence: 99%

Breast Recurrence of Acute Myeloid Leukemia After Bone Marrow Transplantation: A Case Report About Myeloid Sarcoma of the Breast

Varol

Kiraz

Güler

et al. 2021

EJBH

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Myeloid sarcoma of the breast is a rare malignancy, can be seen after bone marrow transplantation. Although there are no specific features for this malignancy which is difficult to diagnose, some common features draw attention in the published case reports. Since there is no consensus on the treatment of myeloid sarcoma of the breast, we aimed to explain our own diagnosis and treatment methods in this case report.

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Myeloid Sarcoma of the Breast Misdiagnosed as Poorly Differentiated Mammary Carcinoma with Lobular Features

Cited by 15 publications

References 0 publications

Granulocytic sarcoma of the breast: A case report

Granulocytic sarcoma of the breast: A case report

Sonographic Features of a Myeloid Sarcoma of the Breast as a Relapse of Acute Myeloid Leukemia After Stem-Cell Transplantation: A Case Report

Breast Recurrence of Acute Myeloid Leukemia After Bone Marrow Transplantation: A Case Report About Myeloid Sarcoma of the Breast

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