Myelopathy associated with mixed connective tissue disease: clinical manifestation, diagnosis, treatment, and prognosis

Hao, Yulei; Xin, Meiying; Wang, Shuang; Ma, Di; Feng, Jiachun

doi:10.1007/s10072-019-03935-y

Cited by 3 publications

(2 citation statements)

References 91 publications

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“…However, we feel that our study is beneficial yet as there are few studies about the urinary tract dysfunction in patients with lumbar and lumbosacral disc herniation surgery whereas there are many studies about urinary tract dysfunction in other spinal disorders. 25,[29][30][31]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Patients with Neurogenic Bladder Following Lumbar and Lumbosacral Disc Herniation Surgery: A Retrospective Cross-Sectional Study

ERTÜRK ÇELİK,

ERSÖZ,

ERDEN

et al. 2024

J PMR Sci

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The aim of this study was to explore the urodynamic features and renal/bladder functions in patients following lumbar or lumbosacral disc herniation surgery. Material and Methods: This retrospective study included 28 patients with a history of lumbar disc herniation surgery. Demographic and clinical data were collected. Data comparisons were performed in the subgroups according to gender, bladder filling sensation, and postoperative duration. Results: A total of 28 patients (16 males, 12 females) with a mean age of 52.9±12.7 years were enrolled. The mean duration since the lumbar disc operation was 26.1±27.1 months. When the patients were allocated two groups with respect to postoperative duration (<6 months, ≥6 months), statistically significant difference was observed in emptying method at admission (p=0.024). Similarly, when the patients were allocated two groups with respect to gender (male-female) statistically significant difference was observed in emptying method at admission (p=0.049). Frequency of indwelling urethral catheter use was higher in male patients and in patients with postoperative duration <6 months while spontaneous voiding/emptying without catheter frequencies were higher in female patients and in patients with a postoperative duration of ≥6 months. Conclusion: Higher indwelling urethral catheter frequencies were observed in patients with short postoperative duration and in male patients. Evaluation of the patients with indwelling urethral catheters as soon as possible and shifting to spontaneous voiding or intermittent catheterisation will diminish the side effects of indwelling urethral catheters in these patients.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Patients with Neurogenic Bladder Following Lumbar and Lumbosacral Disc Herniation Surgery: A Retrospective Cross-Sectional Study

ERTÜRK ÇELİK,

ERSÖZ,

ERDEN

et al. 2024

J PMR Sci

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“…As a chronic autoimmune disorder with multiple systems involvement, MCTD has a broad range of clinical manifestations shared by systemic lupus erythematosus, systemic sclerosis, polymyositis/DM, and rheumatoid arthritis, which is featured with high serum titers of anti-U1 RNP antibodies. 13 The main clinical manifestations of MCTD are puffy hands, Raynaud's phenomenon, arthritis, myositis, pleuritis, pericarditis, sclerodactyly, digital ulcers, and hypomotility or dilatation of esophagus. 14 Our patient did not have the above characteristics, but mainly showed the manifestations of anti-MDA5 + DM, which may be due to treatment in other hospitals, or may be hidden by the clinical manifestations of the latter.…”

Section: Discussionmentioning

confidence: 99%

Anti‐MDA5 antibody dermatomyositis‐associated rapidly progressive interstitial lung disease patient complicated with mixed connective tissue disease: A case report

Liu

Deng

et al. 2023

Int J of Rheum Dis

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Anti‐MDA5 antibody dermatomyositis (DM) is a special type of myositis, which can potentially cause rapidly progressive interstitial lung disease (RP‐ILD). Mixed connective tissue disease (MCTD) is a complex disease with different characteristics of autoimmune connective tissue disease, associated with ILD. Both are rare diseases, and few patients with both diseases have been reported. A 71‐year‐old woman complained of palpitations, with a 2 months history of rash around her hands, extensor surface of right elbow, and the nape of her neck. Subsequently, the patient had acute exacerbation of dyspnea and tachypnea. Anti‐Ro52, U1 RNP and MDA5 antibodies were positive; the presenting evidence was suggestive of anti‐MDA5+DM‐RP‐ILD complicated with MCTD. Our patient deteriorated rapidly and had a fatal outcome, despite “triple therapy” for RP‐ILD. This case illustrates that patients with coexisting anti‐MDA5+DM and MCTD have the former's typical clinical manifestations, and may develop ILD quickly rather than slowly as in MCTD, especially with the coexistence of anti‐Ro52 antibodies.

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A novel arabinogalactan extracted from Epiphyllum oxypetalum (DC.) Haw improves the immunity and gut microbiota in cyclophosphamide‐induced immunosuppressed mice

Dai,

Zhou,

Chen

et al. 2024

eFood

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A novel type I arabinogalactan (AG‐I) polysaccharide (EPS) from Epiphyllum oxypetalum (DC.) Haw's flowers is hypothesized to possess immunomodulatory activity. This study investigated EPS's effects on immune functions and its potential mechanism for enhancing intestinal health in immunosuppressed mice. The results showed that supplementing EPS significantly alleviated immune organ damage, increased the thymus index (p < 0.01), and regulated the key immune factors, including the tumor necrosis factor‐alpha (TNF‐α), immunoglobulin A (IgA), and complement 3 (C3) in the liver (p < 0.05). EPS promoted the expression of intestinal immune barrier and chemical barrier proteins such as interferon‐γ (IFN‐γ) and mucin 2 (MUC2) (p < 0.05), effectively repairing intestinal damage. EPS improved the diversity and structure of intestinal microbiota in immunosuppressed mice (p < 0.05) and significantly altered the abundance of intestinal immune‐related microbial taxa, including Lactobacillaceae and Lactobacillus (p < 0.01). Furthermore, EPS supplementation altered intestinal lactic acid metabolism, significantly increasing lactic acid levels by up to 3.4‐fold (p < 0.01), and enhanced the expression of Gpr81, Wnt3a, and β‐catenin proteins at the bottom of the colonic crypts, which may repair the intestinal physical barrier. Overall, EPS represents a novel AG‐I immunomodulatory dietary polysaccharide that enhances immunity and improves gut health.

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Myelopathy associated with mixed connective tissue disease: clinical manifestation, diagnosis, treatment, and prognosis

Cited by 3 publications

References 91 publications

Evaluation of Patients with Neurogenic Bladder Following Lumbar and Lumbosacral Disc Herniation Surgery: A Retrospective Cross-Sectional Study

Evaluation of Patients with Neurogenic Bladder Following Lumbar and Lumbosacral Disc Herniation Surgery: A Retrospective Cross-Sectional Study

Anti‐MDA5 antibody dermatomyositis‐associated rapidly progressive interstitial lung disease patient complicated with mixed connective tissue disease: A case report

A novel arabinogalactan extracted from Epiphyllum oxypetalum (DC.) Haw improves the immunity and gut microbiota in cyclophosphamide‐induced immunosuppressed mice

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