Myeloperoxidase-antineutrophil cytoplasmic antibody-associated sensorineural hearing loss

Maguchi, Shiroh; Fukuda, Satoshi; Chida, Eiji; Terayama, Yoshihiko

doi:10.1016/s0385-8146(00)00103-6

Cited by 17 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Wegener's granulomatosis, the most frequent affected organs are skin, upper and lower respiratory tracts, the peripheral and central nervous system joints, and kidneys. The main cause of hearing loss in Wegener's granulomatosis is due to otitis media or mastoiditis (13,14). The present patient did not have skin, respiratory tract or nervous system lesions and otitis media or mastoiditis.…”

Section: Discussionmentioning

confidence: 43%

A Patient with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Polyangiitis Who Developed Sensorineural Hearing Loss and Scleritis

et al. 2011

View full text Add to dashboard Cite

A 70-year-old woman was admitted to our hospital because of sudden hearing loss. She was treated with intratympanic dexamethasone, but her hearing impairment progressed. After admission, she developed scleritis of her left eye. Laboratory findings included elevated white blood cell count and C-reactive protein level, microhematuria, and proteinuria. Serology was positive for myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA), but negative for proteinase 3 (PR3)-ANCA. Renal biopsy revealed a single glomerulus with extensive glomerular tuft necrosis, indicating necrotizing vasculitis. She was diagnosed with MPO-ANCA-associated polyangiitis. ANCA-related polyangiitis should be considered in the differential diagnosis of sudden deafness or scleritis.

show abstract

Section: Discussionmentioning

confidence: 43%

A Patient with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Polyangiitis Who Developed Sensorineural Hearing Loss and Scleritis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…However, based on information from our case and another literature review [8][9][10], early diagnosis and initiation of treatment for AAV can save hearing loss. AAV should be considered in the differential diagnosis of hearing loss that is resistant to conventional treatment.…”

Section: Discussionmentioning

confidence: 83%

AP-VAS 2012 case report: a case of myeloperoxidase antineutrophil cytoplasmic antibody-positive microscopic polyangiitis with rapidly progressive glomerulonephritis and hearing loss

et al. 2013

View full text Add to dashboard Cite

A 74-year-old Japanese woman was admitted to our hospital because of fever, fatigue, and hearing loss associated with vertigo. She had a 1-year history of hearing impairment that got worse gradually and had been treated as otitis media with effusion, but without remarkable improvement. After admission, she developed renal dysfunction associated with hematuria and proteinuria. Laboratory tests showed leukocytosis and elevated C-reactive protein. Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) was elevated, but proteinase-3 antineutrophil cytoplasmic antibody (PR3-ANCA) was negative. Renal biopsy revealed pauci-immune focal necrotizing glomerulonephritis with crescents. She was diagnosed as having MPO-ANCA-associated polyangiitis. After treatment with 500 mg methylprednisolone applied intravenously for 3 days, followed by 40 mg prednisolone administered orally, renal function recovered completely. Her hearing also improved. Although otolaryngological symptoms are common in PR3-ANCA associated vasculitis, hearing loss is a rare manifestation of MPO-ANCA associated vasculitis (MPO-AAV). Our case suggests that AAV should be considered in the differential diagnosis of hearing loss.

show abstract

“…Maguchi et al [4] reported an MPO-ANCA-positive case of PTU-induced sensorineural hearing loss. In their patient as in ours, withdrawal of PTU and administration of high-dose methylprednisolone resulted in excellent recovery of hearing.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly most cases of PTU-induced ANCA-associated small-vessel vasculitis have been reported from Japan [2][3][4], but the reasons for this geographic distribution remain unclear. However, most Japanese patients whose hyperthyroidism shows resistance to drug treatment hesitate to undergo radioiodine therapy or thyroidectomy, opting instead for higher doses of drugs over longer periods than commonly used by patients in other countries [5].…”

Section: Discussionmentioning

confidence: 99%

Progressive Bilateral Sensorineural Hearing Loss Induced by an Antithyroid Drug

Sano

Kitahara²,

Kunikata³

2004

ORL

View full text Add to dashboard Cite

We report a patient with antithyroid drug-induced progressive bilateral sensorineural hearing loss associated with myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA). While antithyroid drugs have been linked to MPO-ANCA-associated small-vessel vasculitis, sensorineural hearing loss rarely was noted. A 36-year-old man treated for hyperthyroidism with propylthiouracil (PTU) developed progressive bilateral sensorineural hearing loss accompanied by fever and arthritis. MPO-ANCA were demonstrated in serum. Distortion product otoacoustic emissions test results suggested dysfunction of outer hair cells of the organ of Corti. Inner ear blood flow impairment from ANCA-associated small-vessel vasculitis presumably caused cochlear dysfunction. PTU withdrawal and high-dose methylprednisolone administration greatly improved hearing on both sides.

show abstract

Myeloperoxidase-antineutrophil cytoplasmic antibody-associated sensorineural hearing loss

Cited by 17 publications

References 12 publications

A Patient with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Polyangiitis Who Developed Sensorineural Hearing Loss and Scleritis

A Patient with Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Positive Polyangiitis Who Developed Sensorineural Hearing Loss and Scleritis

AP-VAS 2012 case report: a case of myeloperoxidase antineutrophil cytoplasmic antibody-positive microscopic polyangiitis with rapidly progressive glomerulonephritis and hearing loss

Progressive Bilateral Sensorineural Hearing Loss Induced by an Antithyroid Drug

Contact Info

Product

Resources

About