Myeloperoxidase in the pericardial fluid improves the performance of prediction rules for postoperative atrial fibrillation

Liu, Yisi; Yu, Meng; Wu, Ying; Wu, Fangqin; Feng, Xinwei; Zhao, Haibo

doi:10.1016/j.jtcvs.2021.06.027

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…The plasma samples were analyzed using proteomics, metabolomics, and bioinformatics to identify the differential proteins and differential metabolites. POAF prediction based on different studies differs significantly [ 16 , 29 , 30 , 31 ]. These studies just explored preoperative plasma in patients with POAF; plasma reflects the overall state of the whole body and has no specificity.…”

Section: Discussionmentioning

confidence: 99%

“…MPO is a crucial prerequisite for the structural remodeling of the myocardium, leading to an increased vulnerability to pre-AF [ 37 ]. Yisi Liu et al [ 16 ] explored the local release of MPO into the pericardial space, mainly from damaged atrial tissue, which may be the main source of MPO in postoperative pericardial drainage fluid. Thus, the pericardial MPO concentration is an indicator of the degree of atrial inflammation and atrial MPO activity.…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic Luminex ® assays are magnetic bead-based antibody microarrays that can be used to facilitate simultaneous quantitation in a single sample [ 17 ]. Previous studies have demonstrated the feasibility of using Luminex to measure cytokines in pericardial fluid [ 16 , 18 , 19 ]. In the study, we custom-made a Luminex (R&D Systems, Inc., Minneapolis, MN, USA) panel including MPO to assess the impact of pericardial fluid on POAF.…”

Section: Methodsmentioning

confidence: 99%

“…Structural remodeling of the atria is important in the pathogenesis of ambulatory AF, and this is likely also important for POAF. In previous studies, it was found that MPO was significantly increased in the postoperative pericardial drainage fluid of patients with POAF; however, the MPO of intraoperative pericardial fluid was not explored [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Myeloperoxidase Levels in Pericardial Fluid Is Independently Associated with Postoperative Atrial Fibrillation after Isolated Coronary Artery Bypass Surgery

Liu

Yang

et al. 2022

JCM

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Background: Postoperative atrial fibrillation (POAF) is the most common complication after surgery for atherosclerotic cardiovascular disease (ASCVD) and leads to extended hospital stays and increased mortality. Myeloperoxidase (MPO) in postoperative pericardial drainage fluid is associated with an increased risk of POAF; however, the correlations between MPO in intraoperative pericardial fluid and POAF remain largely unknown. The aim of the study was to evaluate whether MPO is associated with POAF. Methods: A total of 97 patients with no history of atrial arrhythmia who had undergone coronary artery bypass surgery (CABG) were identified. We prospectively measured the levels of MPO in intraoperative pericardial fluid and blood using the human magnetic Luminex assay. Then, the occurrence of atrial fibrillation was continuously observed by postoperative ECG and telemetry strips until discharge. Results: Our data showed that POAF occurred in 24 of 97 patients (24.74%). MPO levels in blood were higher in the POAF group than the SR group (p = 0.064). Patients with POAF had significantly higher intraoperative pericardial fluid MPO levels than patients who remained in SR (p = 0.021). There was no significant correlation between pericardial fluid MPO levels and blood MPO levels (r = −0.47, p = 0.770). In a multivariable logistic regression model, pericardial fluid MPO levels were significantly associated with a higher risk of POAF (odds ratio = 1.016, 95% confidence interval, 1.001–1.031; p = 0.031). Conclusions: Higher intraoperative pericardial fluid MPO levels are linked with POAF in patients undergoing CABG. This finding provides insight into a possible mechanism of MPO in pericardial fluid increase susceptibility to developing POAF in patients undergoing CABG.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Myeloperoxidase Levels in Pericardial Fluid Is Independently Associated with Postoperative Atrial Fibrillation after Isolated Coronary Artery Bypass Surgery

Liu

Yang

et al. 2022

JCM

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“…Atrial electrical and structural remodeling constitute the physiological substrate for this arrhythmia in which MPO was related. 59 Holzwirth et al's study also concluded that increased MPO in AF could originate from the left atrium. The missing association of MPO levels with AF progression or recurrence supports the theory that MPO release due to unknown stimuli induces fibrotic processes and is not a surrogate marker of fibrotic remodeling.…”

Section: Role Of Major Inflammatory Biomarkers In Atrial Fibrillationmentioning

confidence: 94%

The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation

RAFAQAT¹,

AFZAL²,

KHURSHID³

et al. 2022

J Innov Cardiac Rhythm Manage.

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Many studies have reported a relationship between inflammation and atrial fibrillation (AF). According to the literature, inflammation is the key component in pathophysiological processes during the development of AF; the amplification of inflammatory pathways triggers AF, and, at the same time, AF increases the inflammatory state. The plasma levels of several inflammatory biomarkers are elevated in patients with AF; therefore, inflammation might contribute to both the maintenance and occurrence of AF and its thromboembolic complications. Numerous inflammatory markers have been linked to AF, including CD40 ligand, fibrinogen, matrix metalloproteinase (MMP)-9, monocyte chemoattractant protein-1, myeloperoxidase, plasminogen activator inhibitor-1, and serum amyloid A. There are many pathophysiological aspects of AF that are linked to these inflammatory biomarkers, including atrial structural remodeling and atrial dilatation, increased atrial myocyte expression, fluctuations in calcium cycling, cardiac remodeling promotion, increased cardiac myocyte proliferation and terminal differentiation, production of several MMPs, the pathogenesis of atherosclerosis and cardiomyocyte apoptosis, an increased degree of fibrosis in atrial myocardium, and the progression and development of atherogenesis and atherothrombosis. The present review article aims to provide an updated overview and focus on the basic role of different biomarkers of inflammation in the pathophysiological aspects of the pathogenesis of AF.

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Pericardial Immune Cells and Their Evolving Role in Cardiovascular Pathophysiology

Isidoro

Deniset

2023

Canadian Journal of Cardiology

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Myeloperoxidase in the pericardial fluid improves the performance of prediction rules for postoperative atrial fibrillation

Cited by 7 publications

References 31 publications

Myeloperoxidase Levels in Pericardial Fluid Is Independently Associated with Postoperative Atrial Fibrillation after Isolated Coronary Artery Bypass Surgery

Myeloperoxidase Levels in Pericardial Fluid Is Independently Associated with Postoperative Atrial Fibrillation after Isolated Coronary Artery Bypass Surgery

The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation

Pericardial Immune Cells and Their Evolving Role in Cardiovascular Pathophysiology

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