Myeloproliferative Neoplasms: Fatigue, depression & hemoglobi

Abstract

Objective: To evaluate existing relationships and differences in fatigue, depression, and hemoglobin value in individuals with Myeloproliferative Neoplasms. Methods:This study utilized the Fatigue Severity Scale, Beck Depression Inventory-II, and self-report of MPN diagnosis and latest hemoglobin value to assess the dependent variables. To promote optimal opportunity for participation in this study, potential subjects were recruited through three online-based disease-specifi c support groups. A total of 125 individuals consented to participate in the study.Results: Findings support prior fi ndings including that fatigue is a prominent characteristic of MPNs and that depression within this population necessitates further study. Additionally, there is a need for further elucidation regarding underlying causes of fatigue that are not directly associated with hemoglobin value (F(4, 134) = 5.306, p = .001, Wilk's Λ = 0.745, partial η 2 = .137). Conclusions:This study supports prior research that has demonstrated that individuals with MPNs manifest greater-than-expected intensity of fatigue as well as notable accounts of depression. Of particular interest is the average hemoglobin values did not demonstrate anemia, suggesting there is a need to investigate other potential underlying causes.