Myfortic in pediatric transplantation

Zimmerhackl, Lothar Bernd; Jungraithmayr, Therese; Wiesmayr, Silke; Filler, Guido

doi:10.1111/j.1399-3046.2008.00979.x

Pediatric Transplantation

2008

DOI: 10.1111/j.1399-3046.2008.00979.x

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Myfortic in pediatric transplantation

Lothar Bernd Zimmerhackl

Therese Jungraithmayr

Silke Wiesmayr³

et al.

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Cited by 2 publications

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“…To limit gastric toxicity, an enteric‐coated formulation of mycophenolate sodium (EC‐MPS, Myfortic; Novartis Pharma AG, Basel, Switzerland) was developed as an alternative agent to MMF. The enteric coating is acid‐resistant but labile at neutral pH, so as to delay the mycophenolate sodium absorption until the drug reaches the small intestine, thus improving the GI side effects (13–16). The drug is not approved for pediatric use, but it has been used in children off‐license.…”

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confidence: 99%

Efficacy and safety of conversion of mycophenolate mofetil to enteric-coated mycophenolate sodium in Mexican renal transplant children

Reyes

Hernández

Valverde³

et al. 2010

Pediatric Transplantation

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The aim of the study was to evaluate the efficacy and safety of the conversion of MMF to EC-MPS in pediatric renal transplant recipients. We included 12 patients with stable graft function who were receiving MMF treatment. In the first visit, a complete medical examination was performed, which included a GSRS, a nine-point pharmacokinetic profile, samples for renal, liver and hematological tests and evaluation of IMPDH2 gene expression. The patients were transferred to an equimolar dose of EC-MPS. Two wk later, a clinical evaluation and blood collection, as in the first visit were performed. There was no change in serum creatinine, leukocyte count, serum albumin, or transaminase levels, but we found a statistically significant reduction of hemoglobin after conversion (13.2 +/- 1.6 g/dL with MMF vs. 12.5 +/- 1.3 g/dL when receiving EC-MPS). The GSRS total mean score was 16 +/- 12 with MMF vs. 8 +/- 5 with EC-MPA (p < 0.05). There was no statistically significant difference between formulations in the gene expression of IMPDH 2, in the AUC(0-12h) or in C(max). However, peak concentration occurred later with EC-MPS.

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confidence: 99%

Efficacy and safety of conversion of mycophenolate mofetil to enteric-coated mycophenolate sodium in Mexican renal transplant children

Reyes

Hernández

Valverde³

et al. 2010

Pediatric Transplantation

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Children Are Not Small Adults: Similarities and Differences in Renal Transplantation Between Adults and Pediatrics

Puliyanda,

Barday,

Barday

et al. 2023

Seminars in Nephrology

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Myfortic in pediatric transplantation

Cited by 2 publications

References 24 publications

Efficacy and safety of conversion of mycophenolate mofetil to enteric-coated mycophenolate sodium in Mexican renal transplant children

Efficacy and safety of conversion of mycophenolate mofetil to enteric-coated mycophenolate sodium in Mexican renal transplant children

Children Are Not Small Adults: Similarities and Differences in Renal Transplantation Between Adults and Pediatrics

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