MYH9 is a novel cancer stem cell marker and prognostic indicator in esophageal cancer that promotes oncogenesis through the PI3K/AKT/mTOR axis

Kai, Jindan; Cheng, Liang‐Hao; Li, Binfeng; Kang, Kai; Xiong, Fei; Fu, Jing‐Chun; Wang, Sheng

doi:10.1002/cbin.11894

Cited by 20 publications

(9 citation statements)

References 28 publications

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“…Existing studies have proved that activation of mapk12a participates in the heterodimerization of myod and E proteins, leading to myod activation and myogenic cell differentiation [ 37 ]. myh9 encodes the heavy chain of nonmuscle myosin IIA, a ubiquitously expressed cytoplasmic myosin that regulates the actin cytoskeleton, cell migration, and PI3K/Akt/mTOR signaling in cells [ 38 ]. Some studies suggest that myl9 and mylk may play important roles in skeletal muscle growth and strength [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing

Cao

Han

et al. 2023

Aquaculture Nutrition

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Branched-chain amino acids (BCAAs) can be critically involved in skeletal muscle growth and body energy homeostasis. Skeletal muscle growth is a complex process; some muscle-specific microRNAs (miRNAs) are involved in the regulation of muscle thickening and muscle mass. Additionally, the regulatory network between miRNA and messenger RNA (mRNA) in the modulation of the role of BCAAs on skeletal muscle growth in fish has not been studied. In this study, common carp was starved for 14 days, followed by a 14-day gavage therapy with BCAAs, to investigate some of the miRNAs and genes that contribute to the regulation of normal growth and maintenance of skeletal muscle in response to short-term BCAA starvation stress. Subsequently, the transcriptome and small RNAome sequencing of carp skeletal muscle were performed. A total of 43,414 known and 1,112 novel genes were identified, in addition to 142 known and 654 novel miRNAs targeting 22,008 and 33,824 targets, respectively. Based on their expression profiles, 2,146 differentially expressed genes (DEGs) and 84 differentially expressed miRNA (DEMs) were evaluated. Kyoto Encyclopedia of Genes and Genome pathways, including the proteasome, phagosome, autophagy in animals, proteasome activator complex, and ubiquitin-dependent protein catabolic process, were enriched for these DEGs and DEMs. Our findings revealed the role of atg5, map1lc3c, ctsl, cdc53, psma6, psme2, myl9, and mylk in skeletal muscle growth, protein synthesis, and catabolic metabolism. Furthermore, miR-135c, miR-192, miR-194, and miR-203a may play key roles in maintaining the normal activities of the organism by regulating genes related to muscle growth, protein synthesis, and catabolism. This study on transcriptome and miRNA reveals the potential molecular mechanisms underlying the regulation of muscle protein deposition and provides new insights into genetic engineering techniques to improve common carp muscle development.

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Section: Discussionmentioning

confidence: 99%

Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing

Cao

Han

et al. 2023

Aquaculture Nutrition

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“…For nodular fasciitis the typical fusion partner tends to be MYH9 , which is a gene encoding a non-muscle myosin IIA, an acting binding molecular motor helping to power the contraction of actin-myosin filaments 26. Although MYH9 expression has been found in many tumours it’s exact role in neoplastic processes remains unclear 26 27. Other described fusion partners of USP6 are TPM4 , EIF5A , PPP6R3 , CTNNB1 , SPARC , THBS2 , COL6A2 , TNC , SEC31A , COL1A1 , COL1A2, COL3A1 , CALU , NACA , SLFN1 , LDHA , SERPINH1, PDLIM7, MYL12A, PAFAH1B1 and MIR22HG as previously mentioned 9 12–25.…”

Section: Discussionmentioning

confidence: 99%

Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature

et al. 2023

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AimsThis retrospective non-randomised study aims to identify new and rare fusion partners withUSP6in the setting of nodular fasciitis. It has been proven, that nodular fasciitis can harbour different variants ofUSP6fusions, which can be used in routine diagnostics and even determine the biological behaviour of the process.MethodsA total of 19 cases of nodular fasciitis examined between 2011 and 2022 at Motol University Hospital in Prague were included into this study. Next to the histopathological evaluation, all cases were assessed using immunohistochemistry, RT-PCR and Anchored multiplex RNA methods. Patient’s main demographic characteristics and corresponding clinical data were also analysed.ResultsThis study presents one novel (KIF1A) and five rare examples (TMP4, SPARC, EIF5A, MIR22HG, COL1A2) of fusion partners withUSP6among 19 cases of nodular fasciitis.ConclusionIdentification ofUSP6fusion partners in nodular fasciitis helps to understand the biology of such lesions. Moreover, it can be useful in routine histopathological practice of soft-tissues diagnostics, especially in preventing possible misdiagnosis of malignancy.

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“…MYH9 gene, encodes the heavy chain of nonmuscle myosin IIA, regulates cell migration, actin cytoskeleton, cell polarization and signal transduction in cancer cells. There are several studies represented the correlation of MYH9 expression with oncogenesis and chemotherapeutic resistance [42].…”

Section: Discussionmentioning

confidence: 99%

“…Kai and colleagues reported MYH9 as a novel cancer stem cells biomarker, drug target and prognostic indicator in esophageal cancer (EC) which triggered tumorigenesis through regulating PI3K/AKT/mTOR signaling [42]. Another study represented the upregulation of MYH9 in metastatic gastric cancer (GC) tissue which associated with a poor prognosis of GC patients.…”

Section: Discussionmentioning

confidence: 99%

Identification of Common Genes and Pathways Underlying Imatinib and Nilotinib Treatment in CML: a Bioinformatics Study

Hekmatshoar,

Saadat,

Özkan

et al. 2023

Preprint

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Imatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide new targets for CML treatment by transcriptome analysis. Microarray data GSE19567 was downloaded and analyzed from Gene Expression Omnibus (GEO) to identify common genes which are downregulated or upregulated in K562-imatinib and K562-nilotinib treated cells. The differentially expressed genes (DEGs) were assessed, and STRING and Cytoscape were used to create the protein–protein interaction (PPI) network. In imatinib and nilotinib treated groups’ comparison, there were common 626 upregulated and 268 downregulated genes which were differentially expressed. The GO analysis represented the enrichment of DEGs in iron ion binding, protein tyrosine kinase activity, transcription factor activity, ATP binding, sequence-specific DNA binding, cytokine activity, the mitochondrion, sequence-specific DNA binding, plasma membrane and cell-cell adherens junction. KEGG pathway analysis revealed that downregulated DEGs were associated with pathways including microRNAs in cancer and PI3K-Akt signaling pathway. Furthermore, upregulated DEGs were involved in hematopoietic cell lineage, lysosome and chemical carcinogenesis. Among the upregulated genes, MYH9, MYH14, MYL10, MYL7, MYL5, RXRA, CYP1A1, FECH, AKR1C3, ALAD, CAT, CITED2, CPT1A, CYP3A5, CYP3A7, FABP1, HBD, HMBS and PPOX genes were found as hub genes. Moreover, 20 downregulated genes, YARS, AARS, SARS, GARS, CARS, IARS, RRP79, CEBPB, RRP12, UTP14A, PNO1, CCND1, DDX10, MYC, WDR43, CEBPG, DDIT3, VEGFA, PIM1 and TRIB3 were identified as hub genes. These genes have the potential to become target genes for diagnosis and therapy of CML patients.

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MYH9 is a novel cancer stem cell marker and prognostic indicator in esophageal cancer that promotes oncogenesis through the PI3K/AKT/mTOR axis

Cited by 20 publications

References 28 publications

Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing

Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing

Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature

Identification of Common Genes and Pathways Underlying Imatinib and Nilotinib Treatment in CML: a Bioinformatics Study

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