Myiasis in patients with oral squamous cell carcinoma—a systematic review and protocol for management

Jain, Anuj

doi:10.1007/s10006-019-00757-2

Cited by 16 publications

(22 citation statements)

References 18 publications

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“…As stated by Girardi and Scrofernecker, 135 individuals with head and neck cancer are at risk to develop secondary myiasis. A representative percentage of these individuals have neglected and advanced tumors, usually in exposed areas with necrotic tissues, becoming attractive regions for egg deposition 1,138,139 . In that series, most individuals with myiasis were older people and had different types of histopathological diagnoses 135 .…”

Section: Discussionmentioning

confidence: 96%

“…Jain 139 developed a protocol for the management of oral myiasis associated with oral malignant neoplasms. A combination of local treatment (wound flushing with turpentine oil followed by mechanical removal once daily; overnight dressing with turpentine oil; wound flushing with normal saline and 5% povidone iodine solution twice daily; and surgical debridement if possible) and systemic treatment (ivermectin tablets, <15 mg/kg per day for 3 days; clindamycin tablets, 300 mg thrice a day for 5 days; and albendazole tablets, 400 mg twice daily for 3 days) has been recommended to treat these cases.…”

Section: Discussionmentioning

confidence: 99%

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Oral myiasis: Analysis of cases reported in the English literature from 1990 to 2020

Passos

Coelho

Arruda

et al. 2020

Special Care in Dentistry

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Myiasis is an infection caused by the deposition of fly larvae in tissues, and its involvement in the human oral cavity is uncommon. Herein, we have performed a data analysis of published cases of oral myiasis. A search was performed in PubMed, Ovid, Web of Science, Scopus, and LILACS. Geographic distribution, demographic data, associated factors, clinical features, fly types, treatment, and presence of sequelae were analyzed. A total of 122 articles reported the cases of 157 infected individuals. The most affected countries were India (41%) and Brazil (29.5%). Male predominance (67.5%) and a mean of 41.9 years of age were observed. The gingiva (29%) was the most affected site, followed by palate (25%) and lip (21%). There were different forms and combinations of treatments: manual removal of larvae and surgical debridement, application of asphyxiating substances, antibiotic therapy, and use of ivermectin. The condition predominantly affects individuals with neurological and/or locomotor disabilities, of low socioeconomic status, with poor oral hygiene and chemical dependence and individuals with previous injuries or with the absence of lip sealing. The establishment of a standard treatment protocol, enabling comparison in future studies and providing uniformity in treatment strategies offered by health services is strongly recommended.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Oral myiasis: Analysis of cases reported in the English literature from 1990 to 2020

Passos

Coelho

Arruda

et al. 2020

Special Care in Dentistry

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“…Treatment should aim to remove maggots completely, and the simplest measures are irrigation and mechanical removal [10]. Surgical debridement of local site with the use of topical agents, like turpentine oil, chloroform, ethyl chloride, phenol, and olive oil, and systemic treatment with ivermectin were described to be effective in the literature [15,16]. Although topical and systemic treatments were shown to be effective in the management of myiasis, it should be kept in mind that such insecticides kill larvae in the deep layers of the wound and without removal of neutralized decomposing larvae body intoxication can be initiated.…”

Section: Discussionmentioning

confidence: 99%

Massive Orbital Myiasis Caused by Sarcophaga argyrostoma Complicating Eyelid Malignancy

Ayalon

Paitan

Szpila

et al. 2020

Case Reports in Ophthalmological Medicine

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Purpose. To report a case of massive orbital myiasis caused by the larvae of Sarcophaga argyrostoma, complicating eyelid malignancy. Observations. A 98-year-old man first presented to our clinic noted to have a fast-growing lesion on his right upper and lower eyelids. Squamous cell carcinoma of the eyelids was highly suspected, and surgical excision was advised, but the patient refused any surgical or nonsurgical intervention. For the next eight months, the patient’s family members continued to observe a high rate of tumor growth accompanied by deterioration of the general condition. During this whole period, the patient rejected admission to the hospital and was observed by nursing home staff. He was admitted to the emergency room in cachexic, unresponsive condition with fetid discharge and multiple live maggots crawling out from a large necrotic mass over the right orbit. On examination, no eyelids, eyeball, or other ocular tissue could be seen, while an extension of necrotic mass to forehead and midcheek was noted. Manual removal of larvae was performed. The patient passed away eight hours after his admission and larval removal. The maggots were identified as the third-instar larvae of Sarcophaga argyrostoma. Conclusions and Importance. This is the first reported case of home-acquired, massive orbital myiasis by S. argyrostoma. This case illustrates the crucial role of fly control as part of medical and home care in immobile patients. Moreover, it shows the importance of awareness by nursing home staff, paramedical, and medical personnel of possible myiasis, especially in bed-bound patients with skin malignancies and open wounds.

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“…Myiasis is a parasitic disease caused by certain y larvae at some stage of their development, in which human and animal tissues form part of their diet [1] and can be classi ed as primary and secondary. In the primary, the larvae feed on living tissue, and on the secondary tissue necrotic tissue [2]. Socioeconomic conditions are associated with disease risk factors, including advanced age, lack of hygiene, previous diabetes, housing in rural areas, homelessness, neurological diseases, and low purchasing power [3].…”

Section: Introductionmentioning

confidence: 99%

“…Socioeconomic conditions are associated with disease risk factors, including advanced age, lack of hygiene, previous diabetes, housing in rural areas, homelessness, neurological diseases, and low purchasing power [3]. It a ects many regions of the body: nasal mucosa, ear canal, urogenital mucosa, and may occur associated with other pathologies such as squamous cell carcinoma in the oral region, or in traumatized areas [1,2,[4][5][6]. Its treatment is generally performed by debridement, larvae and devitalized tissue removal associated with the administration of ivermectin and antibiotics [7,8].…”

Section: Introductionmentioning

confidence: 99%

Primary Myiasis in Surgical Wound of Mandible Symphisis Fracture

Lauand

Lima

Silva

et al. 2019

Case Reports in Pathology

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A 42 year old patient was referred to the Department of Oral and Maxillofacial Surgery of the Federal University of Uberlândia, for treatment of mandibular fractures (condyles and symphysis), a victim of a run over. The symphysis was surgically approached, using as surgical access the pre-existing laceration in the submental region. Five days after discharge, the patient returned with dehiscence of the wound and physical examination showed infestation by larvae in the symphysis. Mechanical removal and debridement were performed under local anesthesia, where plate exposure was noted. The patient underwent oral ivermectin therapy, intravenous antibiotic therapy and a thorough debridement was performed under general anesthesia due to the invasion of deep spaces in the supra-hyoid region. After 2 weeks, it presented with purulent drainage at the site. The miniplates were replaced by a 2.4 mm reconstruction plate and antibiotic therapy was maintained. Due to the social risk, the patient remained hospitalized for 45 days, when he was discharged with outpatient return, but did not attend the returns.

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Myiasis in patients with oral squamous cell carcinoma—a systematic review and protocol for management

Cited by 16 publications

References 18 publications

Oral myiasis: Analysis of cases reported in the English literature from 1990 to 2020

Oral myiasis: Analysis of cases reported in the English literature from 1990 to 2020

Massive Orbital Myiasis Caused by Sarcophaga argyrostoma Complicating Eyelid Malignancy

Primary Myiasis in Surgical Wound of Mandible Symphisis Fracture

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