2022
DOI: 10.1371/journal.pone.0270820
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MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine

Abstract: Class II myosin complexes are responsible for muscle contraction as well as other non-sarcomeric contractile functions in cells. Myosin heavy chain molecules form the core of these structures, while light chain molecules regulate their stability and function. MYL9 is a light chain isoform that is thought to regulate non-sarcomeric myosin. However, whether this in only in specific cell types or in all cells remains unclear. To address this, we generated MYL9 deficient mice. These mice die soon after birth with … Show more

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Cited by 3 publications
(2 citation statements)
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“…The absence of MYL9 can cause diseases characterized by gastrointestinal functional obstruction [60]. MYL9 deficiency can also lead to smooth muscle dysfunction in many parts of the intestine [61]. Importantly, smooth muscle dysfunction is closely related to constipation [62].…”
Section: Discussionmentioning
confidence: 99%
“…The absence of MYL9 can cause diseases characterized by gastrointestinal functional obstruction [60]. MYL9 deficiency can also lead to smooth muscle dysfunction in many parts of the intestine [61]. Importantly, smooth muscle dysfunction is closely related to constipation [62].…”
Section: Discussionmentioning
confidence: 99%
“…These groups often have particular body deficiencies, so warm-natured drugs can help strengthen the "Qi." As stated in the Plain Questions • The Theory of Yin Yang Correspondence: "External deficiencies of the body can be treated by warming up the "QI" [38]. The phlegm obstructs the "QI," which leads to the stagnation of the "Qi" and tends to turn the depression into heat, so cold-natured drugs also account for a high proportion in treating pulmonary distension.…”
Section: Discussionmentioning
confidence: 99%