MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with α- and β-tubulin

Francke, Felix; Buck, Friedrich; Bächner, Dietmar

doi:10.1016/j.bbrc.2005.07.027

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Because the abnormal methylation of diphthamide occurs in cells with a deletion of EHMT1, it is unlikely that this protein has a role in the abnormal methylation we observed. ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 and to the N termini of ␣-tubulin and ␤-tubulin (33,34). The function of ZMYND19 is not clear.…”

Section: Discussionmentioning

confidence: 99%

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene

Wei

Bera

Wayne

et al. 2013

Journal of Biological Chemistry

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Background: Some children with leukemia do not respond to an immunotoxin containing Pseudomonas exotoxin A. Results:We isolated a resistant cell line and showed that a WDR85 gene deletion causes immunotoxin resistance by allowing formation of diphthamide containing an extra methyl group. Conclusion: Low WDR85 expression can cause immunotoxin resistance in patients. Significance: Analysis of EF2 may reveal why some patients fail therapy.

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Section: Discussionmentioning

confidence: 99%

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene

Wei

Bera

Wayne

et al. 2013

Journal of Biological Chemistry

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Section: Introductionmentioning

confidence: 95%

“…This proposal was generally supported by their primary functional roles in these eukaryotic systems, such as chromatin structure and dynamics (e.g. PHD, ZZ and MYND), the ubiquitin system (RING and B-box), 28 the cytoskeleton (ZZ and MYND), 29,30 and cellular lipidmembranes and lipid-based signaling (C1 and FYVE). [31][32][33][34][35] In our earlier work on the origin of the ubiquitin system we had used contextual information from conserved geneneighborhoods to show that a phylogenetically diverse group of bacteria possess systems combining genes encoding E1s, E2s, JAB domain peptidases and Ub-like proteins.…”

Section: Introductionmentioning

confidence: 95%

Functional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin system

2011

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Recent studies point to a diverse assemblage of prokaryotic cognates of the eukaryotic ubiquitin (Ub) system. These systems span an entire spectrum, ranging from those catalyzing cofactor and amino acid biosynthesis, with only adenylating E1-like enzymes and ubiquitin-like proteins (Ubls), to those that are closer to eukaryotic systems by virtue of possessing E2 enzymes. Until recently E3 enzymes were unknown in such prokaryotic systems. Using contextual information from comparative genomics, we uncover a diverse group of RING finger E3s in prokaryotes that are likely to function with E1s, E2s, JAB domain peptidases and Ubls. These E1s, E2s and RING fingers suggest that features hitherto believed to be unique to eukaryotic versions of these proteins emerged progressively in such prokaryotic systems. These include the specific configuration of residues associated with oxyanion-hole formation in E2s and the C-terminal UFD in the E1 enzyme, which presents the E2 to its active site. Our study suggests for the first time that YukD-like Ubls might be conjugated by some of these systems in a manner similar to eukaryotic Ubls. We also show that prokaryotic RING fingers possess considerable functional diversity and that not all of them are involved in Ub-related functions. In eukaryotes, other than RING fingers, a number of distinct binuclear (chelating two Zn atoms) and mononuclear (chelating one zinc atom) treble clef domains are involved in Ub-related functions. Through detailed structural analysis we delineated the higher order relationships and interaction modes of binuclear treble clef domains. This indicated that the FYVE domain acquired the binuclear state independently of the other binuclear forms and that different treble clef domains have convergently acquired Ub-related functions independently of the RING finger. Among these, we uncover evidence for notable prokaryotic radiations of the ZF-UBP, B-box, AN1 and LIM clades of treble clef domains and present contextual evidence to support their role in functions unrelated to the Ub-system in prokaryotes. In particular, we show that bacterial ZF-UBP domains are part of a novel cyclic nucleotide-dependent redox signaling system, whereas prokaryotic B-box, AN1 and LIM domains have related functions as partners of diverse membrane-associated peptidases in processing proteins. This information, in conjunction with structural analysis, suggests that these treble clef domains might have been independently recruited to the eukaryotic Ub-system due to an ancient conserved mode of interaction with peptides.

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“…For example, MSTRG.12440.1 and its target FFAR4 exhibited crosstalk through miR-141-y and miR-200-y response elements, ENSSSCT00000085972 and its target LEP showed crosstalk through miR-10391, ENSSSCT00000050073 and its target CEBPA exhibited crosstalk through miR486-y, and novel_circ_011355 and its targets PARM1 , ZMYND19, and ADAMTS8 showed crosstalk through miR-196a. FFAR4 , LEP , PARM1 , CEBPA , ZMYND19 , and ADAMTS8 have been reported to be involved in fat metabolism [ 70 , 71 , 72 ]. In addition, several nodes were found to be shared by both lncRNA–miRNA–mRNA co-regulatory networks and circRNA–miRNA–mRNA co-regulatory networks, namely ssc-miR-196a, ZMYND19 , PARM1 , and ATAMTS8 .…”

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes and Regulatory Competitive Endogenous RNA (ceRNA) Networks Underlying Intramuscular Fat Content in Yorkshire Pigs with Extreme Fat Deposition Phenotypes

Ding

Hou

Ling

et al. 2022

IJMS

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Intramuscular fat (IMF) content is vital for pork quality, serving an important role in economic performance in pig industry. Non-coding RNAs, with mRNAs, are involved in IMF deposition; however, their functions and regulatory mechanisms in porcine IMF remain elusive. This study assessed the whole transcriptome expression profiles of the Longissimus dorsi muscle of pigs with high (H) and low (L) IMF content to identify genes implicated in porcine IMF adipogenesis and their regulatory functions. Hundreds of differentially expressed RNAs were found to be involved in fatty acid metabolic processes, lipid metabolism, and fat cell differentiation. Furthermore, combing co-differential expression analyses, we constructed competing endogenous RNAs (ceRNA) regulatory networks, showing crosstalk among 30 lncRNAs and 61 mRNAs through 20 miRNAs, five circRNAs and 11 mRNAs through four miRNAs, and potential IMF deposition-related ceRNA subnetworks. Functional lncRNAs and circRNAs (such as MSTRG.12440.1, ENSSSCT00000066779, novel_circ_011355, novel_circ_011355) were found to act as ceRNAs of important lipid metabolism-related mRNAs (LEP, IP6K1, FFAR4, CEBPA, etc.) by sponging functional miRNAs (such as ssc-miR-196a, ssc-miR-200b, ssc-miR10391, miR486-y). These findings provide potential regulators and molecular regulatory networks that can be utilized for research on IMF traits in pigs, which would aid in marker-assisted selection to improve pork quality.

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MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with α- and β-tubulin

Cited by 7 publications

References 17 publications

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene

A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene

Functional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin system

Identification of Candidate Genes and Regulatory Competitive Endogenous RNA (ceRNA) Networks Underlying Intramuscular Fat Content in Yorkshire Pigs with Extreme Fat Deposition Phenotypes

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