Myoblast Therapies Constitute a Safe and Efficacious Platform Technology of Regenerative Medicine for the Human Health Industry

Law, Peter K.; Li, Wenbin; Song, Qibin; Song, Shi Jun; Ren, Jun; Yao, Manye; Li, Qiaoyun; Shi, Qizhong; Wang, Keqiang; Wang, Jing; Ye, Lei; Ma, Jianhua; Haider, Khawaja Husnain; Su, Liping; Lü, Ping; Cheng, Weyland; Ao, Ming Zhang; Law, Danlin M.

doi:10.1007/978-981-16-6016-0_34-1

Cited by 2 publications

(4 citation statements)

References 106 publications

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“…The earliest signs of aging are loss of energy and strength due to genetically programed degeneration of ATP-producing mitochondria (Figure 1) [4]. Mitochondrial degeneration diminishes energy production, body warmth, physical activity, leading to disuse atrophy and degeneration of fast-twitch (Type II A and B) muscle fibers [6] that account for slow movement and incoordination in the elderlies.…”

Section: Pathogenesis and Signs Of Agingmentioning

confidence: 99%

“…Thus, the FDA approved Phase II and Phase III 50-billion-MTT protocol that was demonstrated to be safe and efficacious in human clinical trials [8] literally implanted 50 billion muscle nuclei and 5 trillion mitochondria into 80 large muscle groups of single Duchenne muscular dystrophy (DMD) boys and limb-girdle muscular dystrophy (LGMD) adults. Many of these subjects demonstrated significant improvement in quality of life and life prolongation [4]. They represented a small group of seriously genetically defective individuals saved by MTT.…”

Section: Myoblast Anti-aging Therapymentioning

confidence: 99%

“…Striated muscles, cardiac muscles and smooth muscles that occupy approximately 55% by volume of the human body are constantly at work to maintain body temperature and normal metabolism. Degradation of the power network of adeno-triphosphate (ATP) production leads directly to cell apoptosis, organ malfunction and eventually human death [4].…”

Section: Myoblast Anti-aging Therapymentioning

confidence: 99%

“…MTT prevents organ failure, intervening with disease onset and/or progression, thus prolonging the life expectancy of the human subjects [3]. By maintaining normal function of various bodily organs in which myofibers are a constituent, MTT sustains the human subject in good health with a good quality of life [4]. It is an area with great promise that can be traced to one of the earliest INDs of cell therapy and gene therapy, numbered BB-IND 5108, approved on May 13, 1993 by the Food and Drug Administration (FDA) in facilitating the availability of safe and effective treatments [5].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Cell Therapy in Anti-Aging Regenerative Cosmetology

Law¹,

Ren²

2023

OJRM

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As post-WWII baby boomer approaching age 80, Anti-Aging Regenerative Cosmetology (AARC) has been developed and patented for beautifying and strengthening the human body using live cells; to enhance the appearance and function of various bodily parts to provide health and aestheticism of human being throughout life. It is a combined cosmetic and preventive medicine to intervene with and to correct the undesirable phenotypic expression of aging. The intrinsic properties of myoblasts and foreskin fibroblasts in development and regeneration are harnessed to formulate a genetic cell therapy program which is safe and efficacious as previously been tested in FDA Phase III clinical trials. Myoblasts are selected for strength development and foreskin fibroblasts for tenacity and smooth-to-the-touch. Both cell types are highly mitotic and non-carcinogenic. In additional to providing large quantities of nuclei as regenerative gene medicine, and of mitochondria as energy generators, myoblasts secret tumor necrosis factor alpha (TNF-α) for skin whitening and melanoma prevention. Myoblasts, because of their small size, spindle shape, and resilience, grow readily on collagen and laminin within wrinkles of skin surfaces, thus enhancing the color, luster, and texture of the skin "plated" with them. Alternatively, they can be injected subcutaneously as cell filler to reduce wrinkles. Intramuscular injection of myoblasts can augment the size, shape, consistency, tone, and strength of muscle groups, improving the lines, contours, and vitality to sculpt a youthful appearance. By improving cell genetics and organ functions, the program holds promise to sustain the human subject in good health and appearance, with a good quality of life and life prolongation.

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Section: Pathogenesis and Signs Of Agingmentioning

confidence: 99%

Section: Myoblast Anti-aging Therapymentioning

confidence: 99%

Section: Myoblast Anti-aging Therapymentioning

confidence: 99%