“Myoblastoma” of the neurohypophysis

Burston, J.; John, Roger; Spencer, Herta

doi:10.1002/path.1700830216

Cited by 50 publications

(7 citation statements)

References 9 publications

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“…These included perineural fibroblasts (Pearse, 1950) and histiocytes (Azzopardi, 1956). Smooth muscle fibres were proposed as the origin of tumours arising in the gastrointestinal tract (Churg and Work, 1959) and urinary bladder (Christ and Ozzello, 1971), and pituicytes for tumours arising in the neurohypophysis (Burston et al, 1962).…”

Section: Discussionmentioning

confidence: 99%

Granular cell myoblastoma: positive staining for carcinoembryonic antigen.

Shousha¹,

Lyssiotis²

1979

J Clin Pathol

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SUMMARY An immunoperoxidase technique for the detection of carcinoembryonic antigen was applied to 10 cases of granular cell myoblastoma. Consistent, strong, intracytoplasmic granular staining, which can be easily interpreted, was obtained in all cases. Schwannomas, neurofibromas, dermatofibromas, and leiomyomas were negative. The test is helpful in confirming doubtful cases. The results tend to support the suggestion that granular cell myoblastoma is derived from perineural rather than endoneural cells.In a recent study of carcinoembryonic antigen (CEA) in benign and malignant breast lesions using the immunoperoxidase technique, a case of granular cell myoblastoma included in the series stained very strongly for CEA (Shousha and Lyssiotis, 1978). This prompted us to review and stain other granular cell myoblastomas from various sites in an attempt to investigate the consistency of the results and the possibility of using the test in the diagnosis, and explaining the histogenesis, of these lesions. Cases and methodsTen cases diagnosed as granular cell myoblastoma were found in the files of the Histopathology Departments of the Charing Cross and Royal Free Hospitals during the period 1965 to 1976. The diagnosis was confirmed by the examination of sections stained with haematoxylin and eosin, periodic acidSchiff, reticulin and phosphotungstic acid. Sections 5 microns thick were cut from stored paraffinembedded blocks of tissue. The sections were then deparaffinised in xylene and stained for CEA using the peroxidase-labelled antibody sandwich technique, as described in detail elsewhere (Shousha and Lyssiotis, 1978). Briefly, endogenous peroxidase was blocked with 30 % hydrogen peroxide in methanol, and nonspecific background staining was reduced by 1:5 normal swine serum. The sections were then treated consecutively with 1:50 rabbit anti-CEA serum, normal swine serum, and peroxidase-labelled swine anti-rabbit IgG. Thorough

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Section: Discussionmentioning

confidence: 99%

Granular cell myoblastoma: positive staining for carcinoembryonic antigen.

Shousha¹,

Lyssiotis²

1979

J Clin Pathol

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“…Rarely, GCT also arise in the nervous system. The most common intracranial site is the region of the infundibulum [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] . However, GCT can be found in cranial and peripheral nerves 5,[22][23][24][25][26][27][28][29] as well as within cerebral hemispheres [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Morphological and immunohistochemical characterization of granular cells in non‐hypophyseal tumours of the central nervous system

Rickert¹,

Kuchelmeister

Gullotta³

1997

Histopathology

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We report 14 biopsy cases of granular cell tumours (GCT) of the central nervous system (CNS) outside the pituitary gland. In six cases the granular cells determined the morphology (actual GCT), the other eight consisted of different CNS tumours with a varying granular cell component. Pronounced immunoreactivity for ubiquitin and alpha-1-antichymotrypsin could be found in all investigated tumours, while GFAP, neuron specific enolase, von Willebrand factor, vimentin, S-100 protein, alpha-1-antitrypsin, actin, and the neurofilaments 68 kDa and 160 kDa showed mostly weak positivity in some cases. Four out of eight GCT showed no immunoreactivity for MIB1; the other four cases had a proliferation index between 0.5% and 15%. Six out of nine cases were positive for p53. We consider granular cells to originate from different cell types. Thus, although morphologically identical, GCT are actually biologically heterogeneous. GCT of the CNS may represent gliomas of mostly astrocytic origin with a metabolically induced transformation of some tumour cells into granular cells.

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“…Another possible cause of pituitary stalk enlargement is that of benign pituitary cell tumours. Over the years, they have received various names, including choristomas (Sternberg, 1921;Houtteville et al, 1977), myoblastomas (Abrikossof, 1926), and pituicytomas (Liss & Kahn, 1958;Burston et al, 1962); there is still controversy about the origin and histopathological classification of these lesions. They are generally considered to be benign withlittle growth potential (Luse & Kernohan, 1955).…”

Section: Discussionmentioning

confidence: 99%

Endocrine Aspects of Pituitary Stalk Enlargment

Puig

Webb

Pozo

et al. 1987

Clinical Endocrinology

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Four patients with various endocrine deficiencies of a predominantly hypothalamic nature are described, in whom computed topographic scans demonstrated pituitary stalk enlargement. In one, a disseminated papular skin eruption with regional pleomorphism and spontaneous regression appeared 4 years after the development of the initial symptoms of diabetes insipidus, and led to a diagnosis of xanthoma disseminatum, a rare type of histiocytosis. It is suggested that this patient's endocrine dysfunction is also due to histiocytic involvement of the hypothalamus and/or pituitary stalk. In view of the prolonged lapse of time between the initial endocrine manifestations and the eventual diagnosis, even though no cause is apparent in the other three patients, it is suggested that close follow-up be carried out to rule out such a possibility in patients with this endocrine-radiological entity.

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“Myoblastoma” of the neurohypophysis

Cited by 50 publications

References 9 publications

Granular cell myoblastoma: positive staining for carcinoembryonic antigen.

Granular cell myoblastoma: positive staining for carcinoembryonic antigen.

Morphological and immunohistochemical characterization of granular cells in non‐hypophyseal tumours of the central nervous system

Endocrine Aspects of Pituitary Stalk Enlargment

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