Myocardial abscess secondary to staphylococcal septicemia: Diagnosis with 3D echocardiography

Jariwala, Pankaj; Punjani, Arshad; Mirza, Shaeq; Boorugu, Harikishan; Madhawar, Dilip Babu

doi:10.1016/j.ihj.2012.12.005

Cited by 6 publications

(5 citation statements)

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“…S . aureus is also the most common cause of bacterial myocarditis, with fatal outcomes [ 108 – 110 ]. Currently, there are no murine models to study MRSA induced myocarditis.…”

Section: Discussionmentioning

confidence: 99%

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Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300

Nagarajan,

Scoggin,

Gupta

et al. 2024

PLoS Genet

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Staphylococcus aureus (S. aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life threatening conditions, including endocarditis, pneumonia, and sepsis. To identify host genes modulating this host-pathogen interaction, we infected 25 Collaborative Cross (CC) mouse strains with methicillin-resistant S. aureus (MRSA) and monitored disease progression for seven days using a surgically implanted telemetry system. CC strains varied widely in their response to intravenous MRSA infection. We identified eight ‘susceptible’ CC strains with high bacterial load, tissue damage, and reduced survival. Among the surviving strains, six with minimal colonization were classified as ‘resistant’, while the remaining six tolerated higher organ colonization (‘tolerant’). The kidney was the most heavily colonized organ, but liver, spleen and lung colonization were better correlated with reduced survival. Resistant strains had higher pre-infection circulating neutrophils and lower post-infection tissue damage compared to susceptible and tolerant strains. We identified four CC strains with sexual dimorphism: all females survived the study period while all males met our euthanasia criteria earlier. In these CC strains, males had more baseline circulating monocytes and red blood cells. We identified several CC strains that may be useful as new models for endocarditis, myocarditis, pneumonia, and resistance to MRSA infection. Quantitative Trait Locus (QTL) analysis identified two significant loci, on Chromosomes 18 and 3, involved in early susceptibility and late survival after infection. We prioritized Npc1 and Ifi44l genes as the strongest candidates influencing survival using variant analysis and mRNA expression data from kidneys within these intervals.

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“…S . aureus is also the most common cause of bacterial myocarditis, with fatal outcomes [ 108 – 110 ]. Currently, there are no murine models to study MRSA induced myocarditis.…”

Section: Discussionmentioning

confidence: 99%

“…Current models of IE require anesthetizing C57BL6/J mice and physically damaging their heart valve using a catheter [106,107]. S. aureus is also the most common cause of bacterial myocarditis, with fatal outcomes [108][109][110]. Currently, there are no murine models to study MRSA induced myocarditis.…”

Section: Plos Geneticsmentioning

confidence: 99%

Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300

Nagarajan,

Scoggin,

Gupta

et al. 2024

PLoS Genet

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“…However, they presented five characteristic echocardiographic findings, including prosthetic valve rocking, sinus of Valsalva aneurysm, anterior aortic root thickness of 10 mm or greater, posterior aortic root thickness of 10 mm or greater, perivalvular density in a septum of 14 mm or greater, and reported that the presence of one or more of these findings was associated with a positive predictive value of 86% and a negative predictive value of 87% for the presence of perivalvular abscess. Real-time 3D TTE in a patient without valvular inflammation has also been reported to describe detailed structure of a septal myocardial abscess with irregular septation (Jariwala et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Septal myocardial abscess in a Thoroughbred mare

Suzuki¹,

Kato²,

Yamaga³

et al. 2023

Equine Veterinary Education

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An 11-year-old multiparous Thoroughbred mare with a history of colic was referred for further evaluation. Clinical findings at the time of initial examination included arrhythmia, tachycardia, tachypnoea and hypothermia without marked signs of abdominal pain.Electrocardiography revealed ventricular tachycardia at a rate of 211 beats/min. Lidocaine was administered as a constant rate infusion to treat the arrhythmia, and the heart rate and rhythm were normalised. There were no abnormal findings on ultrasonography of the abdomen and thorax. An echocardiographic examination revealed a hypoechoic spherical area within the muscular part of the intraventricular septum. Unfortunately, the mare died suddenly 3 days after treatment. Post-mortem examination confirmed the presence of an encapsulated abscess in the intraventricular septum. Staphylococcus aureus and Staphylococcus chromogenes were isolated from the lesion. It was thought to be responsible for the arrhythmia seen in this case. This is the first case of a septal myocardial abscess in a horse.

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“…C57BL6 mice are typically used as background strains for the IE model [81]. S. aureus is also the most common cause of rare bacterial myocarditis, with fatal outcomes in some cases [82][83][84]. Currently, there are no murine models to study MRSA induced myocarditis.…”

Section: Discussionmentioning

confidence: 99%

Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistantStaphylococcus aureusUSA300

Nagarajan

Scoggin

Gupta

et al. 2023

Preprint

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Staphylococcus aureus (S. aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life-threatening conditions, including endocarditis, pneumonia, and sepsis. To identify host genes modulating this host-pathogen interaction, we infected 25 Collaborative Cross (CC) mouse strains with methicillin-resistant S. aureus (MRSA USA300) and monitored disease progression for seven days. We identified eight ‘susceptible’ CC strains with high bacterial load, tissue damage, and reduced survival. Among the surviving strains, six with minimal colonization were classified as ‘resistant’, while the remaining six tolerated higher organ colonization (‘tolerant’). The kidney was the most heavily colonized organ, but liver colonization was better correlated with reduced survival. We identified four CC strains with sex differences: females survived the study period while males met our euthanasia criteria earlier. In these CC strains, males had more baseline circulating monocytes and red blood cells. We identified several CC strains that may be useful as new models for endocarditis, myocarditis, pneumonia, and resistance to MRSA infection. Resistant strains had higher pre-infection circulating neutrophils than susceptible and tolerant strains. GM-CSF, IL-1-alpha, IL-15, IL-28, and IL-31 levels increased significantly in tolerant strains after infection. Using RNA seq, we identified two pathways, IL-1 and ERK1/ERK2, as potentially involved in the mechanism of tolerance. QTL analysis identified two significant loci, on Chromosomes 18 and 3, involved in early and late survival after infection. We prioritized Npc1 and Ifi44l genes as the strongest candidates influencing survival using variant analysis and mRNA expression data within these intervals.

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Myocardial abscess secondary to staphylococcal septicemia: Diagnosis with 3D echocardiography

Abstract: A 56 years old gentleman with staphylococcal septicemia with metastatic abscesses in spleen and heart. Real time 3D trans thoracic echocardiography could not only confirm the diagnosis of myocardial abscess but also well delineate it and identify adjacent structures.

Cited by 6 publications

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Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300

Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300

Septal myocardial abscess in a Thoroughbred mare

Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistantStaphylococcus aureusUSA300

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