Myocardial anaerobiosis in anemia in ur?mic man

Delano, Barbara G.; Nacht, R; Friedman, Eli A.; Krasnow, Norman

doi:10.1016/0002-9149(72)90413-4

Cited by 12 publications

(2 citation statements)

References 34 publications

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“…Confirmation of in creased tissue oxygenation was afforded by a previous study noting a rise in transcutaneous oxygen pressure after rhEPO [20]. In renal dialysis patients with coronary artery disease, a reduction in the extent of S-T depression on their exercise electrocardiogram and an improvement in myocardial lactate balance could be demonstrated during step testing following blood transfusion [21].…”

Section: Discussionmentioning

confidence: 74%

Exercise in Hemodialysis Patients after Treatment with Recombinant Human Erythropoietin

Lundin

Akerman²,

Chesler³

et al. 1991

Nephron

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To assess the effect of substantial increases in blood hemoglobin (Hb) caused by treatment with recombinant human erythropoietin (rhEPO) on exercise capacity in maintenance hemodialysis patients, we evaluated 10 patients (7 men and 3 women) at a mean age of 44.3 ± 8.4 years on maintenance hemodialysis for a mean of 29.7 ± 30.2 months by treadmill exercise to exhaustion. The patients were tested before administration of rhEPO and after a minimum 1 g/dl rise in Hb. With a change in Hb from 7.1 ± 1.4 to 9.8 ± 2.1 g/dl, peak oxygen consumption (VO₂peak) with exercise increased 50.3 ± 9% (T1 = 15.1 ± 5.3, T2 = 22.7 ± 4.6 ml O₂/kg/min, p < 0.05). Respiratory exchange ratio (RER) at a given submaximal exercise level (3 mph, 6% of elevation) decreased significantly (T1 = 1.13 ± 0.24, T2 = 0.92 ± 0.08, p < 0.05). The rhEPO-mediated increase in Hb was associated with an increased VO₂ peak – an improvement of the peak exercise capacity and a reduced submaximal RER – reflecting a reduction in anaerobic metabolism at activities of daily living.

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Section: Discussionmentioning

confidence: 74%

Exercise in Hemodialysis Patients after Treatment with Recombinant Human Erythropoietin

Lundin

Akerman²,

Chesler³

et al. 1991

Nephron

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“…Delano et al. studied dialysis patients with patent coronaries and measured lactate concentration in the coronary sinus blood during stimulation with isoprenaline (157). Release of lactate was found pointing to myocardial ischemia despite the lack of obstructive lesions of the coronaries.…”

Section: Pathological Features Of Heart Morphology In Uremiamentioning

confidence: 99%

NON‐CORONARY HEART DISEASE IN DIALYSIS PATIENTS: Hypertrophy and Fibrosis in the Cardiomyopathy of Uremia—Beyond Coronary Heart Disease

Gross¹,

Ritz

2008

Seminars in Dialysis

148

131

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Cardiac disease is the leading cause of death in uremic patients. In contrast to previous opinion, coronary events account for a relatively small proportion of cardiac deaths, the most common causes being sudden death and heart failure. Against this background the current text will discuss noncoronary cardiac pathology, specifically the pathogenesis and the morphological findings caused by (pathological) cardiac hypertrophy, cardiac interstitial fibrosis and microvascular disease.

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The Management of Coronary Artery Disease in Patients with End-Stage Renal Disease

Rutsky¹,

Rostand²

1992

Cardiac Dysfunction in Chronic Uremia

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Myocardial anaerobiosis in anemia in ur?mic man

Cited by 12 publications

References 34 publications

Exercise in Hemodialysis Patients after Treatment with Recombinant Human Erythropoietin

Exercise in Hemodialysis Patients after Treatment with Recombinant Human Erythropoietin

NON‐CORONARY HEART DISEASE IN DIALYSIS PATIENTS: Hypertrophy and Fibrosis in the Cardiomyopathy of Uremia—Beyond Coronary Heart Disease

The Management of Coronary Artery Disease in Patients with End-Stage Renal Disease

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