Myocardial and Microvascular Injury Due to Coronavirus Disease 2019

Montone, Rocco Antonio; Iannaccone, Giulia; Meucci, Maria Chiara; Gurgoglione, Filippo Luca; Niccoli, Giampaolo

doi:10.15420/ecr.2020.22

Cited by 47 publications

(46 citation statements)

References 19 publications

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“…With this cascade come endothelial dysfunction and endothelitis, which further worsen cardiac function [ 2 ]. This phenomenon may lead to several manifestations of myocardial injury, from myocarditis and arrhythmia, to Takotsubo cardiomyopathy [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis

et al. 2020

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Introduction: The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. Methods: We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. Results: We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1–23.8% with substantial heterogeneity (I2 = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. Conclusion: The incidence of COVID-19-related myocardial injury ranges from 16.1–23.8%. Further larger studies are anticipated, as the pandemic is still ongoing.

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Section: Discussionmentioning

confidence: 99%

Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis

et al. 2020

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“…Within a month after the earthquake, 16 patients had presented with TTS, of which 11 (68.75%) were diagnosed on the day that the disaster hit. Furthermore, 13 of the patients lived in locations that recorded the greatest seismic intensities, often being near the epicenter of the earthquake 33 . A similarly large earthquake was recorded in 2011, devastating Christchurch, New Zealand, and accounting for 185 fatalities.…”

Section: Methodsmentioning

confidence: 99%

Takotsubo Syndrome and COVID-19: Associations and Implications

Shah

et al. 2021

Current Problems in Cardiology

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“…Acute coronary syndrome (ACS) in the context of viral infection may be related to atherosclerotic plaque rupture precipitated by endothelial cell damage, a cytokine storm and a heightened inflammatory state 4 Furthermore, admission with an ACS during the COVID -19 pandemic in which large numbers of patients were hospitalised with COVID-19, may increase the risk of nosocomial transmission of COVID-19 in this vulnerable patient group.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England

Rashid

Curzen

et al. 2020

Preprint

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Background: Patients with underlying cardiovascular disease and Coronavirus disease 2019 (COVID-19) infection are at increased risk of morbidity and mortality. However, there is limited information on management and outcomes of patients presenting with acute coronary syndrome (ACS) and concomitant COVID19 infection. Objectives: This multisource national analysis of live data from England was designed to characterise the presenting profile and outcomes of patients hospitalized with ACS and COVID-19 infection. Methods: Multisource data from all acute NHS hospital in England was linked to study the characteristics and outcomes of patients hospitalized with COVID-19 ACS compared to non COVID-19 ACS patients. Hierarchical multilevel models were constructed to study the association between COVID19 ACS and in-hospital and 30-day mortality. Results: Between 1st March 2020 and 31st May 2020, 517 (4.0%) were admitted with COVID- 19 ACS from a total of 12,958 ACS patients. COVID-19 ACS patients were generally older, BAME ethnicity, more comorbid and had unfavourable presenting characteristics compared to non-COVID-19 ACS patients. They were less likely to receive invasive coronary strategy in the form of coronary angiography (67.7% vs 81.0%), PCI (30.2% vs 53.9%), dual antiplatelet medication 76.3% vs 88.0%), and other important secondary medication. Patients with COVID-19 ACS had higher in-hospital (aOR 3.27 95%CI 2.41-4.42) and 30-day mortality (aOR 6.53 95%CI 5.1-8.36) compared to non COVID-19 ACS group. Conclusion: COVID-19 infection is prevalent but less frequent in the patients hospitalized with ACS in England. Presence of COVID-19 infection in patients with ACS is associated with significant mortality hazard.

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Myocardial and Microvascular Injury Due to Coronavirus Disease 2019

Cited by 47 publications

References 19 publications

Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis

Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis

Takotsubo Syndrome and COVID-19: Associations and Implications

Clinical Characteristics and Outcomes of COVID-19 Positive Acute Coronary Syndrome Patients; a multisource Electronic Healthcare Records Study from England

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