Myocardial angiogenesis after chronic ghrelin treatment in a rat myocardial infarction model

Yuan, Mingjie; HeHUANG,; Hu, Hongyao; Liquan,; HongJIANG,; Huang, Congxin

doi:10.1016/j.regpep.2012.08.013

Cited by 31 publications

(20 citation statements)

References 24 publications

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“…Data are expressed as mean±SEM for n=6 animals per group the gastric mucosa of rats exposed to ischemia-reperfusion (Konturek et al 2006). Also, our results are in contrast with an earlier report using a rat model of myocardial infarction to demonstrate chronic injection of ghrelin (4 weeks) increased VEGF protein expression in the peri-infarct zone and suggested that ghrelin may induce angiogenesis after myocardial infarction (Yuan et al 2012).…”

Section: Discussioncontrasting

confidence: 99%

The Anti-Edematous Effect of Ghrelin in Brain Hypoxia is Associated with Decreasing Expression of Vascular Endothelial Growth Factor

et al. 2015

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There is increasing evidence that vascular endothelial growth factor (VEGF) has a role in the development of vascular leakage in the hypoxic brain. Our recent work showed an anti-edematous effect of ghrelin on brain hypoxia. However, the underlying mechanisms by which ghrelin exerts its anti-edematous effect are still unclear. For this purpose, we examined the effects of ghrelin on VEGF expression in the hypoxic brain. Adult male Wistar rats were divided into acute or chronic controls, acute or chronic hypoxia, and ghrelin-treated acute or chronic hypoxia groups. Systemic hypoxia was induced in rats by a hypoxic chamber (O2 10-11 %) for 2 days (acute) or 10 days (chronic). Effects of ghrelin on VEGF expression were evaluated using immunoblotting. Our data revealed that acute and chronic hypoxia increased VEGF expression in both acute and chronic hypoxia (P < 0.001). Ghrelin significantly reduced this expression in hypoxic conditions (P < 0.001). Our findings demonstrated the beneficial effects of ghrelin might be mediated, at least in part, through a decline in VEGF production.

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Section: Discussioncontrasting

confidence: 99%

The Anti-Edematous Effect of Ghrelin in Brain Hypoxia is Associated with Decreasing Expression of Vascular Endothelial Growth Factor

et al. 2015

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“…In addition to the stimulation of GH release, ghrelin has been demonstrated to influence food intake, glucose metabolism, gastrointestinal function, cardiovascular performance, and immune responses [26]. Recently, several studies have indicated that ghrelin could be a pro-angiogenic factor or anti-angiogenic factor in different cell types [27][28][29][30][31][32][33][34][35][36] and that it may serve as an endogenous regulator of angiogenesis [27][28][29][30][31][32][33][34][35][36]. These findings indicate that ghrelin may be closely related to angiogenesis, and its effects on angiogenesis may vary according to cell type.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…A number of studies have demonstrated that ghrelin may serve as an endogenous regulator of angiogenesis [27][28][29][30][31][32][33][34][35][36]. Indeed, in vitro studies have indicated that ghrelin can inhibit FGF-2-stimulated angiogenesis in rat brain microvascular endothelial cells (NECs) [27] and HUVECs [28] by inhibiting TK/MAPK-dependent cascades.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In in vivo studies, ghrelin stimulated retinal angiogenesis via GHSR1a-mediated signaling pathways in rats [31] and induced angiogenesis in rats after MI through the enhancement of vascular endothelial growth factor (VEGF) and inhibition of apoptosis [32]. However, a recent study reported that systemic administration of ghrelin did not restore angiogenesis in hindlimb ischemia in normal C57BL/6 mice and diet-induced obese mice [33].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Octanoylated ghrelin attenuates angiogenesis induced by oxLDL in human coronary artery endothelial cells via the GHSR1a-mediated NF-κB pathway

Wang

Chen

et al. 2015

Metabolism

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“…Ghrelin signaling has increasingly been recognized as a key regulator of obesity, insulin resistance and diabetes; intriguingly, many of these regulatory functions appear to be independent of ghrelin's effect on food intake (4–8). This current review is focused on the most recent findings of ghrelin in glucose homeostasis (9–11), energy-homeostasis (7, 12), heart disease (13–16), muscular atrophy (17, 18), bone metabolism (8, 19, 20), and cancer development/progression (21, 22). …”

Section: Introductionmentioning

confidence: 99%

Ghrelin

Pradhan¹,

Samson²,

Sun³

2013

Current Opinion in Clinical Nutrition and Metabolic Care

247

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Purpose of review Ghrelin is a multifaceted gut hormone which activates its receptor, growth hormone secretagogue receptor (GHS-R). Ghrelin's hallmark functions are its stimulatory effects on food intake, fat deposition and growth hormone release. Ghrelin is famously known as the “hunger hormone”. However, ample literature indicates that the functions of ghrelin go well beyond its role as an orexigenic signal. Here we have reviewed some of the most recent findings on ghrelin and its signaling in animals and humans. Recent findings Ghrelin regulates glucose hemostasis by inhibiting insulin secretion and regulating gluconeogenesis/glycogenolysis. Ghrelin signaling decreases thermogenesis to regulate energy expenditure. Ghrelin improves the survival prognosis of myocardial infarction by reducing sympathetic nerve activity. Ghrelin prevents muscle atrophy by inducing muscle differentiation and fusion. Ghrelin regulates bone formation and metabolism by modulating proliferation and differentiation of osteoblasts. Ghrelin is also involved in cancer development and metastasis; ghrelin and GHS-R mRNA are highly expressed in metastatic forms of cancers. Summary In addition to ghrelin's effects on appetite and adiposity, ghrelin signaling also plays crucial roles in glucose- and energy-homeostasis, cardioprotection, muscle atrophy, bone metabolism and cancer. These multifaceted roles of ghrelin make ghrelin and GHS-R highly attractive targets for drug development.

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Myocardial angiogenesis after chronic ghrelin treatment in a rat myocardial infarction model

Cited by 31 publications

References 24 publications

The Anti-Edematous Effect of Ghrelin in Brain Hypoxia is Associated with Decreasing Expression of Vascular Endothelial Growth Factor

The Anti-Edematous Effect of Ghrelin in Brain Hypoxia is Associated with Decreasing Expression of Vascular Endothelial Growth Factor

Octanoylated ghrelin attenuates angiogenesis induced by oxLDL in human coronary artery endothelial cells via the GHSR1a-mediated NF-κB pathway

Ghrelin

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