Myocardial blood flow evaluation with dynamic cadmium-zinc-telluride single-photon emission computed tomography: Bright and dark sides

D’Antonio, Adriana; Assante, Roberta; Zampella, Emilia; Mannarino, Teresa; Buongiorno, Pietro; Cuocolo, Alberto; Acampa, Wanda

doi:10.1016/j.diii.2023.02.001

Cited by 9 publications

(4 citation statements)

References 66 publications

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“…Indeed, various studies have demonstrated that the evaluation by CZT-SPECT of MBF and MFR, in addition to providing a good correlation not only with noninvasive but also invasive measures and good diagnostic ability in the presence of significant strictures, it can also be helpful in the identification of microvascular compromise when considered in the clinical context. 29 These findings may encourage the use of this new technique to a better risk stratification and patient management. The wide availability of CZT SPECT will facilitate the clinical use of SPECT MBF quantification, both for diagnostic and prognostic purposes.…”

mentioning

confidence: 90%

“…The new generation of solid-state CZT-SPECT cameras are taking a leading role in this competition, representing a chief technological progress in this field. 27,28 Recently, D'Antonio et al 29 summarized the state of the art on MBF and MPR evaluation by dynamic CZT-SPECT, highlighting its lights and shadows and the major issues to solve to optimize this technique. Dynamic CZT-SPECT-based MBF quantization is sure to play an increasingly important role as an alternative to PET, and new data are continually being published confirming this trend.…”

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confidence: 99%

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Including myocardial flow reserve by PET in prediction models: Ready to fly?

Petretta¹,

Panico

Mainolfi

et al. 2023

Journal of Nuclear Cardiology

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confidence: 90%

mentioning

confidence: 99%

Including myocardial flow reserve by PET in prediction models: Ready to fly?

Petretta¹,

Panico

Mainolfi

et al. 2023

Journal of Nuclear Cardiology

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“…Single Photon Emission Computed Tomography (SPECT) imaging, while widespread in nuclear cardiovascular diagnostics, faces limitations in MBF due to the low sensitivity and temporal resolution of traditional sodium iodide cameras [83]. The advent of cadmium zinc telluride detectors presents a breakthrough, significantly improving sensitivity and resolution, thus facilitating dynamic SPECT imaging for accurate MBF quantification [84]. While initial studies yield optimistic flow estimates, the advancement of SPECT imaging necessitates broader multicenter trials to enhance its processing techniques and benchmark against conventional methods for flow reserve assessment [85,86].…”

Section: Minoca 61 Pathophysiologymentioning

confidence: 99%

Transient Left Ventricular Dysfunction from Cardiomyopathies to Myocardial Viability: When and Why Cardiac Function Recovers

Trimarchi,

Teresi,

Licordari

et al. 2024

Biomedicines

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Transient left ventricular dysfunction (TLVD), a temporary condition marked by reversible impairment of ventricular function, remains an underdiagnosed yet significant contributor to morbidity and mortality in clinical practice. Unlike the well-explored atherosclerotic disease of the epicardial coronary arteries, the diverse etiologies of TLVD require greater attention for proper diagnosis and management. The spectrum of disorders associated with TLVD includes stress-induced cardiomyopathy, central nervous system injuries, histaminergic syndromes, various inflammatory diseases, pregnancy-related conditions, and genetically determined syndromes. Furthermore, myocardial infarction with non-obstructive coronary arteries (MINOCA) origins such as coronary artery spasm, coronary thromboembolism, and spontaneous coronary artery dissection (SCAD) may also manifest as TLVD, eventually showing recovery. This review highlights the range of ischemic and non-ischemic clinical situations that lead to TLVD, gathering conditions like Tako-Tsubo Syndrome (TTS), Kounis syndrome (KS), Myocarditis, Peripartum Cardiomyopathy (PPCM), and Tachycardia-induced cardiomyopathy (TIC). Differentiation amongst these causes is crucial, as they involve distinct clinical, instrumental, and genetic predictors that bode different outcomes and recovery potential for left ventricular function. The purpose of this review is to improve everyday clinical approaches to treating these diseases by providing an extensive survey of conditions linked with TLVD and the elements impacting prognosis and outcomes.

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“…However, there is a lack of studies focused on the standardization of dynamic CZT-SPECT. At the moment, different research groups are using various types of dynamic SPECT protocols, stress tests and post-processing [ 4 , 5 , 6 , 7 , 8 ]. There are data showing the need to use motion correction; however, the impact of attenuation correction has not been proven yet.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Kinetic Models and Attenuation Correction on Cadmium–Zinc–Telluride Single-Photon Emission Computed Tomography (CZT SPECT)-Derived Myocardial Blood Flow and Reserve: Correlation with Invasive Angiography Data

Mochula,

Maltseva,

Kopeva

et al. 2024

JCM

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(1) Background: The objective of this study was to determine the optimal post-processing model for dynamic cadmium–zinc–telluride single-photon emission computed tomography (CZT-SPECT). (2) Methods: A total of 235 patients who underwent diagnostic invasive coronary angiography within three months of the SPECT and those who had coronary computed tomography angiography (CCTA) before SPECT (within 3 months) were enrolled in this study. Each SPECT study was processed to obtain global and regional stress myocardial blood flow (sMBF), rest-MBF (rMBF), myocardial flow reserve (MFR) and flow difference (FD) estimates obtained with 1-tissue-compartment (1TCM) and net retention (NR) modes, both with and without attenuation correction. (3) Results: The use of AC led to significantly higher sMBF, rMBF and DF values obtained by 1TCM compared those values derived by 1TCM with NAC; the lowest values of stress MBF and rest MBF were obtained by 1TCM_NAC. The resting flow, MFR and DF were significantly (p < 0.005) higher in the AC model than in NAC. All quantitative variables were significantly (p < 0.05) higher in NR_NAC than in the 1TC_NAC model. Finally, sMBF, rMBF and FD showed significantly (p < 0.05) higher values by using 1TMC_AC compared to NR_AC. (4) Conclusions: We suggested that 1-compartment and net retention models correctly reflect coronary microcirculation and can be used for clinical practice for evaluating quantitative myocardial perfusion by dynamic SPECT. Attenuation correction is an important step in post-processing dynamic SPECT data, which increases the consistency and diagnostic accuracy of models.

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Myocardial blood flow evaluation with dynamic cadmium-zinc-telluride single-photon emission computed tomography: Bright and dark sides

Cited by 9 publications

References 66 publications

Including myocardial flow reserve by PET in prediction models: Ready to fly?

Including myocardial flow reserve by PET in prediction models: Ready to fly?

Transient Left Ventricular Dysfunction from Cardiomyopathies to Myocardial Viability: When and Why Cardiac Function Recovers

The Influence of Kinetic Models and Attenuation Correction on Cadmium–Zinc–Telluride Single-Photon Emission Computed Tomography (CZT SPECT)-Derived Myocardial Blood Flow and Reserve: Correlation with Invasive Angiography Data

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