Myocardial collagen, the effects of right ventricular hypertrophy and its involution induced by changes in atmospheric pressure

Caspari, P. G.; Newcomb, M.; Gibson, Keith; Harris, P.

doi:10.1093/cvr/12.3.173

Cited by 4 publications

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“…Such a manoeuvre increases the pressure work done by the heart. Since the left ventricular wall and septum comprise about 80% of the ventricular mass (Gibson & Harris, 1972;Caspari et al, 1978), it was suggested that increased workload in vitro does not affect cardiac protein degradation. More recently, Morgan et al (1980) have presented data which suggested that rat hearts performing external work in vitro exhibited a lower rate of protein degradation compared with Langendorff (1895)-perfused hearts (which do no external work).…”

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Effect of insulin and lack of effect of workload and hypoxia on protein degradation in the perfused working rat heart

Smith¹,

Sugden²

1983

Biochemical Journal

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1. Protein degradation was studied in the glucose (5 mM)-perfused working rat heart preparation of Taegtmeyer, Hems & Krebs [(1980) Biochem. J. 186. 701-711]. 2. The effects of cardiac workload were investigated in three different preparations: (a) control (low workload), (b) increased pressure workload (simulating conditions of aortic pressure in vivo) and (c) increased volume workload. There was no effect of increased workload on protein degradation in preparation (b) or (c) when compared with preparation (a). Insulin inhibited protein degradation in all three preparations. Significantly greater inhibition by insulin was observed in the increased-pressure-workload preparation (b). 3. Hypoxia was induced by the partial replacement of O2 in the gaseous phase by N2. Hearts maintained their cardiac output when O2 content was decreased from 95% to 55% by volume, but the stability of the preparation was less at 50% O2. Lactate output was significantly increased at O2 contents of 65% or less. The rate of protein degradation was not different from control values (95% O2) in perfusions with 65, 55 or 50% O2. 4. We conclude that acutely increased workload or acute hypoxia does not affect protein degradation in the perfused working rat heart when cardiac output is relatively stable.

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Effect of insulin and lack of effect of workload and hypoxia on protein degradation in the perfused working rat heart

Smith¹,

Sugden²

1983

Biochemical Journal

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Structural Alterations in the Hypertrophied and Failing Myocardium

Bishop¹

1984

Developments in Cardiovascular Medicine

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Myocardial collagen in different forms of heart hypertrophy in the rat

Medugorac

1980

Res. Exp. Med.

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The hydroxyproline concentration, representing collagen content, has been investigated in normal and hypertrophied rat hearts. Enlargement of the heart was produced by four methods: a. Experimental renal hypertension (Goldblatt rats); b. Spontaneous hypertension (SHR); c. Experimental aortic stenosis; d. Swimming training. In spontaneously hypertensive rats the free wall of the right and left ventricles and the septum were analyzed separately. Furthermore, the left ventricular free wall was divided into endomyocardial and epimyocardial slices to permit separate investigation. Otherwise, the hydroxyproline concentration was always analyzed in left ventricular tissue. In swimming rats the absolute enlargement was very slight (15%), whereas the hydroxyproline concentration remained unchanged. The degree of hypertrophy was greater in all other experimental animals and was associated with an increase in hydroxyproline concentration in hypertrophied tissue. There was a positive correlation between the rate of hydroxyproline concentration increase and the degree of hypertrophy. The findings only vary in different experimental groups of Goldblatt rats at an early stage. Four weeks after surgery we found a left ventricular hypertrophy of 34%, whereas hydroxyproline concentration in left ventricular tissue was unchanged in comparison to control values. In spontaneously hypertensive rats the increase in hydroxyproline concentration in endomyocardial areas was considerably greater than in epimyocardial areas. Significant differences in water retention and nitrogen content (microgram/mg dry tissue) of hypertrophied and normal ventricular tissue were not found.

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Myocardial collagen, the effects of right ventricular hypertrophy and its involution induced by changes in atmospheric pressure

Cited by 4 publications

References 0 publications

Effect of insulin and lack of effect of workload and hypoxia on protein degradation in the perfused working rat heart

Effect of insulin and lack of effect of workload and hypoxia on protein degradation in the perfused working rat heart

Structural Alterations in the Hypertrophied and Failing Myocardium

Myocardial collagen in different forms of heart hypertrophy in the rat

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