Myocardial Creatine Concentration in Various Nonischemic Heart Diseases Assessed by 1H Magnetic Resonance Spectroscopy

Nakae, Ichiro; Mitsunami, Kenichi; Matsuo, Shinro; Inubushi, Toshiro; Morikawa, Shigehiro; Tsutamoto, Takayoshi; Koh, Terue; Horie, Minoru

doi:10.1253/circj.69.711

Cited by 31 publications

(34 citation statements)

References 28 publications

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“…Metabolite quantification (Table 2) is consistent with previously published data on control tissue [15] and, as found using pattern recognition, showed a reduction of metabolites in ischemic and at-risk areas as compared to controls. This illustrates the possibility of using an hypothesis free approach (pattern recognition) to identify the metabolites most related to the condition under study for a more detailed analysis.…”

Section: Hr-mas Spectrasupporting

confidence: 89%

1H NMR-based metabolomic identification of at-risk areas after myocardial infarction in swine

Barba

Jaimez-Auguets

Rodríguez‐Sinovas

et al. 2007

Magn Reson Mater Phy

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At-risk and, especially, necrotic areas have a reduced concentration of NMR visible metabolites as compared to control tissue, total creatine (phosphorilated and unphosphorilated) being the single most important metabolite in the different discriminant models. Creatine concentration decreased from 18.28 +/- 0.84 micromols/g fresh weight in controls to 12.58 +/- 2.89 (P < 0.05) and 9.96 +/- 2.21 (P < 0.01) in at-risk and necrotic areas, respectively. Taurine and myo-inositol were also involved in the discriminant models. HR-MAS spectra also showed an increase in lipid signals at 0.9 and 1.28 ppm as markers of necrotic tissue. These results support the view that the analysis of in vivo (1)H MRS may have value in differentiating normal, at-risk and infarcted myocardium.

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Section: Hr-mas Spectrasupporting

confidence: 89%

1H NMR-based metabolomic identification of at-risk areas after myocardial infarction in swine

Barba

Jaimez-Auguets

Rodríguez‐Sinovas

et al. 2007

Magn Reson Mater Phy

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“…The phosphocreatine (PCr)-to-ATP ratio is decreased in many cardiac disorders, including dilated cardiomyopathy, left ventricular hypertrophy, coronary artery disease, and heart failure, as well as infarcted heart (26–28). Bioenergetic deficits may predict clinical severity (27,29,30) and are accompanied by decreased creatine content, determined by 1 H-MRS (31), which also characterizes nonviable postischemic myocardium (32). Despite normal left ventricular morphology, mass, and systolic function, diabetic heart exhibits a decreased PCr-to-ATP ratio, which is associated with underlying diastolic dysfunction (33).…”

Section: In Vivo Mrs Studies Of Human Metabolismmentioning

confidence: 99%

Magnetic Resonance Spectroscopy Studies of Human Metabolism

2011

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“…In a series of 1 H-MRS studies, Nakae et al [38, 71–73] have shown a significant reduction in myocardial creatine content in patients with heart failure secondary to non-ischaemic diseases (dilated cardiomyopathy, hypertrophic cardiomyopathy, cardiac amyloidosis or valvular heart disease). All these studies were limited by the small number of patients enrolled, which prevented a statistically powerful individual analysis of each disease.…”

Section: Creatine Metabolismmentioning

confidence: 99%

“…Myocardial creatine concentration correlated positively with cardiac function (LVEF) [38, 71, 73] and free fatty acid uptake [38] and negatively with plasma brain natriuretic peptides (BNP) levels [71, 72]. Finally, total creatine levels could potentially be predictive of subsequent heart failure; Nakae et al [73] showed that creatine levels had been lower in patients who were later admitted to hospital for heart failure in the year following the metabolic assessment (11.3 ± 1.0 vs. 18.6 ± 5.9 µmol/l). However, these findings need to be confirmed prospectively in larger studies and compared with standard predictive markers.…”

Section: Creatine Metabolismmentioning

confidence: 99%

1H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism

et al. 2012

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Magnetic resonance spectroscopy (MRS) is the only non-invasive, non-radiation-based technique for investigating the metabolism of living tissue. MRS of protons (1H-MRS), which provides the highest sensitivity of all MR-visible nuclei, is a method capable of detecting and quantifying specific cardiac biomolecules, such as lipids and creatine in normal and diseased hearts in both animal models and humans. This can be used to study mechanisms of heart failure development in a longitudinal manner, for example, the potential contribution of myocardial lipid accumulation in the context of ageing and obesity. Similarly, quantifying creatine levels provides insight into the energy storage and buffering capacity in the heart. Creatine depletion is consistently observed in heart failure independent of aetiology, but its contribution to pathophysiology remains a matter of debate. These and other questions can in theory be answered with cardiac MRS, but fundamental technical challenges have limited its use. The metabolites studied with MRS are much lower concentration than water protons, requiring methods to suppress the dominant water signal and resulting in larger voxel sizes and longer scan times compared to MRI. However, recent technical advances in MR hardware and software have facilitated the application of 1H-MRS in humans and animal models of heart disease as detailed in this review.

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Myocardial Creatine Concentration in Various Nonischemic Heart Diseases Assessed by 1H Magnetic Resonance Spectroscopy

Cited by 31 publications

References 28 publications

1H NMR-based metabolomic identification of at-risk areas after myocardial infarction in swine

1H NMR-based metabolomic identification of at-risk areas after myocardial infarction in swine

Magnetic Resonance Spectroscopy Studies of Human Metabolism

1H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism

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