Myocardial Cyclic Nucleotide Levels following Coronary Artery Ligation

Krause, Ernst‐Georg; Ziegelhöffer, A; Fedelsova, Margarita; Styk, J; Kostolanski, S.; Gabauer, I; Blasig, Ingolf E.; Wollenberger, A

doi:10.1159/000402012

Cited by 23 publications

(13 citation statements)

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“…Ventricular arrhythmias induced by myocardial ischaemia with or without reperfusion has been shown to be preceded by or associated with an increase in myocardial cAMP levels in the cat (Con et al 1978),'in the dog (Krause et al 1978), in the pig (Podzuweit & Lubbe 1977;Podzuweit et al 1981); and in the isolated working rat heart (Crome el al. 1983), suggesting that the eleva- tion of cAMP may predispose to ventricular arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

NALOXONE ATTENUATES AUGMENTATION OF cAMP LEVELS AND ARRHYTHMIAS FOLLOWING MYOCARDIAL ISCHAEMIA AND REPERFUSION IN THE ISOLATED PERFUSED RAT HEART

Lee

Wong

1986

Clin Exp Pharma Physio

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The effects of myocardial ischaemia and reperfusion on arrhythmias and cAMP levels were studied using the Langendoff isolated perfused rat heart preparation. Myocardial ischaemia and reperfusion caused arrhythmias and augmentation of cAMP levels concurrently, supporting the suggestion that myocardial cAMP is related to arrhythmias. Pretreatment with naloxone attenuated both arrhythmias and augmentation of cAMP levels to a similar extent. The results suggest that the anti-arrhythmic effect of naloxone may involve myocardial cAMP.

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Section: Discussionmentioning

confidence: 99%

NALOXONE ATTENUATES AUGMENTATION OF cAMP LEVELS AND ARRHYTHMIAS FOLLOWING MYOCARDIAL ISCHAEMIA AND REPERFUSION IN THE ISOLATED PERFUSED RAT HEART

Lee

Wong

1986

Clin Exp Pharma Physio

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“…Myocardial cyclic AMP levels are increased during ischaemia as a result of increased sympathetic activation (Krause et al ., 1978) and this is involved in the generation of ventricular arrhythmias that result when a coronary artery is occluded (recently reviewed by Du & Dart, 1999). In contrast, the parasympathetic nervous system, which can also be activated during myocardial ischaemia, is antifibrillatory (Corr et al ., 1986; Verrier, 1986).…”

Section: Introductionmentioning

confidence: 99%

The antiarrhythmic effects of ischaemic preconditioning in anaesthetized dogs are prevented by atropine; role of changes in baroreceptor reflex sensitivity

Babai

Papp

Parratt

et al. 2002

British J Pharmacology

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1 Dogs, anaesthetized with chloralose and urethane, were subjected to a 25 min occlusion of the left anterior descending coronary artery. This resulted in ventricular ectopic activity, a reduction in barore¯ex sensitivity (BRS, measured following the intravenous administration of phenylephrine), elevations in the epicardial ST-segment and increases in the degree of inhomogeneity of electrical activation, both measured from the ischaemic region of the left ventricular wall. 2 These changes were markedly reduced when the 25 min occlusion was preceded, 20 min earlier, by a 5 min (preconditioning) occlusion of the same coronary artery (e.g. VF during ischaemia reduced from 40% in the controls to 0%; P50.05; BRS increased from 1.22+0.23 preocclusion to 1.61+0.25 mmHg ms 71 post-occlusion in preconditioned dogs; cf. 1.28+0.29 to 0.45+0.12 mmHg ms 71 respectively in the controls, P50.05). 3 These bene®cial e ects of preconditioning were prevented by the administration, 10 min prior to the 25 min coronary artery occlusion, of atropine (1 mg kg 71 i.v. followed by a continuous infusion of 0.04 mg kg 71 h 71 ). For example, VF during occlusion was increased from 0% in the preconditioned dogs to 40% (P50.05) in the presence of atropine and BRS was again reduced during occlusion (from 1.75+0.29 to 0.30+0.08 mmHg ms 71 ; P50.05). 4 We conclude that preconditioning reduces arrhythmia severity during ischaemia by favourably modifying cardiac autonomic receptor mechanism through enhancing vagal in¯uences.

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“…In our experiments, surprisingly, the rise in the level of cyclic AMP in the overloaded non-ischaemic portion following CAL, exceeded this rise in the ischaemic part of the same heart. An elevated level of this nucleotide in the nonischaemic zone following CAL has been observed by several authors (3,7,17,31). The protracted post-CAL rise in cyclic AMP level has been suspected (17) to be largly due to catecholamines released from the adrenal medulla (5).…”

Section: Discussionmentioning

confidence: 95%

“…Whereas PGI2 or iloprost seem not to influence the latter catecbolamine release (34), a moderate effect of prostacyclin, lowering the blood noradrenaline level, has been demonstrated recently (10). Neither PGI2 nor iloprost administration caused a normalization in the cyclic AMP level to the preligation value, which has been found in the range of 0.5 to 0.7 pmol/mg wet weight in tissue freeze-clamped immediately after thoracotomy (3,7,17). However, the differences in cyclic AMP following 3 h of CAL in the examined ischaemic and non-ischaemic zone were abolished, which could be relevant for the diminution of the known arrhythmogenic effect of this nucleotide (28) by these prostanoids.…”

Section: Discussionmentioning

confidence: 99%

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Prostacyclin and iloprost: Equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation

et al. 1987

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The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 h after the onset of ischaemia, resulted in a normalization and an appreciable reduction in the loss of high energy phosphates in the non-ischaemic and ischaemic left ventricular muscle, respectively, leading to an improvement in the phosphate potential of the cardiac tissue. A reduction in the ischemia-induced rise in cAMP levels was observed, indicating a lower catecholamine overflow in the presence of these drugs. PGI2 and iloprost in the dose employed significantly decreased cardiac preload, which was found to be elevated in the untreated animals after coronary artery ligation. The observed effect of PGI2 and its mimetic on the haemodynamics, as well as on myocardial cAMP and high energy phosphate levels of the heart, may be considered helpful in the phase of temporary imbalance between energy demand and supply during acute ischaemia.

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Myocardial Cyclic Nucleotide Levels following Coronary Artery Ligation

Cited by 23 publications

References 0 publications

NALOXONE ATTENUATES AUGMENTATION OF cAMP LEVELS AND ARRHYTHMIAS FOLLOWING MYOCARDIAL ISCHAEMIA AND REPERFUSION IN THE ISOLATED PERFUSED RAT HEART

NALOXONE ATTENUATES AUGMENTATION OF cAMP LEVELS AND ARRHYTHMIAS FOLLOWING MYOCARDIAL ISCHAEMIA AND REPERFUSION IN THE ISOLATED PERFUSED RAT HEART

The antiarrhythmic effects of ischaemic preconditioning in anaesthetized dogs are prevented by atropine; role of changes in baroreceptor reflex sensitivity

Prostacyclin and iloprost: Equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation

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