Myocardial deformation imaging unmasks subtle left ventricular systolic dysfunction in asymptomatic and treatment-naïve HIV patients

Karavidas, Apostolos; Xylomenos, George; Matzaraki, Vassiliki; Papoutsidakis, Nikolaos; Leventopoulos, Georgios; Farmakis, Dimitrios; Lazaros, George; Perpinia, Anastasia; Arapi, Sophia; Paisios, Nikolaos; Parissis, John; Pyrgakis, Vlasios; Gargalianos, Panagiotis

doi:10.1007/s00392-015-0866-8

Cited by 13 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…But later study done by Cetin et al 16 showed positive correlation between reduced CD4 count and GLS value, though there were no significant difference between different CD4 level group below and greater than 300. There was no significant differences in conventional echocardiographic parameters between HIV population and healthy population except for transmittal E velocity (P value of 0.001) which were significantly lower in the HIV group and this finding were similar to the study done by Karavidas et al 19 and Mendes et al 15 . The diastolic function abnormalities such as reduced transmitral E velocity, an increased peak of A velocity, and an increased isovolumetric relaxation time and early filling duration has been described in HIV patients with wide variability in its incidence.…”

Section: Discussionsupporting

confidence: 89%

“…Our study evaluate the relationship of LV function with GLS in HIV patients to baseline CD4 count, HIV viral Load, duration of HIV diagnosis, HAART therapy and HAART therapy duration showed patients with CD4 count less than 300 cell/mm 3 had significantly lower GLS value less than -18% compared with higher CD4 count. Previous study done by Onur et al 18 and Karavidas et al 19 found no relationship between CD4 T-cells and systolic strain. But later study done by Cetin et al 16 showed positive correlation between reduced CD4 count and GLS value, though there were no significant difference between different CD4 level group below and greater than 300.…”

Section: Discussionmentioning

confidence: 78%

“…The strength of the present Study was that our study population included 57% female with larger sample size and younger age population compared to the previous study done by Karavidas et al 19 , Mendes et al 15 and Cetin et al 16 . Our study had tried to overcome the limitation of previous study of underrepresented female population and less sample size.…”

Section: Limitation Of the Studymentioning

confidence: 78%

“…The main analysis of the present study showed that asymptomatic HIV-infected patients without cardiovascular disease had significantly lower GLS value despite having normal LV systolic function compared to the that of healthy individuals which were similar to previous study done by Mendes et al 15 and Cetin et al 16 . There were also very few study done with Doppler/TDI strain imaging and strain rate done by Sims A et al 17 , Onur et al 18 and Karavidas et al 19 which all have demonstrated impaired strain and strain rate despite having normal systolic function in HIV patients compared to the healthy control group.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of left ventricular systolic function by Myocardial Deformation Imaging in asymptomatic HIV patients

et al. 2019

View full text Add to dashboard Cite

Background and Aims: Despite improvements in clinical care, evidence from both industrialized and developing countries indicates that the prevalence of subclinical cardiac dysfunction in individuals with well-controlled HIV infection may approach 50% and represent a newly recognized comorbid condition. The aim of our study was to reveal abnormalities in cardiac function using conventional transthoracic echocardiography and left ventricular strain imaging in HIV infected patients without cardiovascular disease. Methods: This was a hospital based, single center descriptive cross-sectional comparative study conducted in National Academy of Medical Sciences (NAMS), Bir Hospital which included HIV patients with baseline examination including a patient medical history, clinical examination, baseline CD4 count, viral load and a standardized transthoracic echocardiography and strain imaging examination and the findings were compared among age and sex frequency matched healthy adult population. Results: Our study enrolled 142 patients out of which 95 HIV positive patients (mean age 36.7±9.2 years with 58% female) and 47 healthy control (mean age 33.7±8 years with 57.4% female). The median duration of HIV diagnosis was 7 years (IQR 2, 10) and median CD4 count was 464 cells/mm3 (IQR 259,750). There was no significant difference in conventional echocardiographic parameters between two groups except for transmitral E velocity that was lower in HIV group (P value of 0.001). The HIV population has lower mean global longitudinal strain (GLS) value of -19.92% ± 2.54 SD compared to the healthy control population with mean of -21.39% ± 1.54 SD(P value of 0.001) and patients with CD4 count less than 300 cell/mm3 had GLS value significantly lower than -18% (P value of 0.05). Conclusion: HIV infected population without established cardiovascular disease have subclinical left ventricular dysfunction revealed by GLS imaging technique.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 78%

Section: Limitation Of the Studymentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of left ventricular systolic function by Myocardial Deformation Imaging in asymptomatic HIV patients

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Unfortunately, this study was did not account for the duration of HIV infection and heterogeneity of the population studied [16]. In contrast, all the patients in our study were previously healthy and were documented HIV seroconverters with an average of 10 months duration of infection prior to echocardiography.…”

Section: Discussionmentioning

confidence: 94%

Echocardiographic Assessment of Asymptomatic US Air Force Members with Early HIV Infection

Alvarado

Usry

Gore

et al. 2019

Preprint

View full text Add to dashboard Cite

Objective People living with HIV (PLHIV) are at increased risk for cardiovascular disease (CVD) and development of subclinical echocardiographic abnormalities. However, there is scant evidence of the echocardiographic changes that occur shortly after seroconversion. In this study we describe the echocardiographic evaluations of asymptomatic US Air Force members who were diagnosed with HIV infection and evaluated at the San Antonio Military Medical Center between September 1, 2015 and September 30, 2016. Results Patients (n=50) were predominantly male (96%), mostly African American (60%), with a mean age of 28 years. At HIV diagnosis, the mean viral load was 112,585 copies/mL and CD4 count was 551 cells/uL. All were found to have normal left ventricular systolic ejection fraction (EF) and global longitudinal strain (GLS) however evidence of right ventricular dilatation and left ventricular remodeling was observed in 7 (14%) and 13 (26%) patients, respectively. Subgroup analyses showed no significant differences in echocardiographic findings by HIV disease severity or CVD risk factors (p >0.05 for all).This study suggests that untreated HIV may have a low impact on the development of echocardiographic abnormalities shortly after seroconversion. Longitudinal studies are warranted to determine the optimal CVD risk assessment strategies for PLHIV.

show abstract

Intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory

et al. 2017

View full text Add to dashboard Cite

show abstract

Myocardial deformation imaging unmasks subtle left ventricular systolic dysfunction in asymptomatic and treatment-naïve HIV patients

Abstract: HIV infection itself is accompanied by subclinical systolic dysfunction, not apparent to standard echocardiography that can be unmasked though using sensitive echocardiographic techniques.

Cited by 13 publications

References 23 publications

Evaluation of left ventricular systolic function by Myocardial Deformation Imaging in asymptomatic HIV patients

Evaluation of left ventricular systolic function by Myocardial Deformation Imaging in asymptomatic HIV patients

Echocardiographic Assessment of Asymptomatic US Air Force Members with Early HIV Infection

Intra-procedural determination of viability by myocardial deformation imaging: a randomized prospective study in the cardiac catheter laboratory

Contact Info

Product

Resources

About