Myocardial Deformation in Patients with Beta‐Thalassemia Major: A Speckle Tracking Echocardiographic Study

Cheung, Yiu‐fai; Liang, Xue‐cun; Chan, Godfrey Chi‐Fung; Wong, Samuel Po‐Shing; Ha, Shau Yin

doi:10.1111/j.1540-8175.2009.01005.x

Cited by 37 publications

(37 citation statements)

References 40 publications

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“…Our findings of impaired myocardial deformation in the different dimensions, reduced torsion, and mechanical dyssynchrony in patients agree with those reported previously . Importantly, 3DSTE enables the comprehensive evaluation of all these parameters with a single acquisition.…”

Section: Discussionsupporting

confidence: 92%

“…5,6 Furthermore, these conventional echocardiographic indices have not been shown to correlate with myocardial iron load. On the other hand, we 7,8 and others 9,10 have demonstrated potential advantages of 2D strain imaging in unmasking subclinical impairment of left ventricular (LV) mechanics in these patients. Limited evidence further suggests that 2D strain imaging may be useful in quantifying myocardial iron deposition.…”

mentioning

confidence: 98%

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Role of Three‐Dimensional Speckle Tracking Echocardiography in the Quantification of Myocardial Iron Overload in Patients with Beta‐Thalassemia Major

Hwang

et al. 2016

Echocardiography

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 98%

Role of Three‐Dimensional Speckle Tracking Echocardiography in the Quantification of Myocardial Iron Overload in Patients with Beta‐Thalassemia Major

Hwang

et al. 2016

Echocardiography

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“…The introduction of the new STE method has enabled a more precise assessment of LV function [24] and enables regional and global assessment of the left ventricle. Previous studies have indicated that 2D STE is more sensitive than conventional echocardiography for detecting subclinical ventricular dysfunction in various clinical disorders [25,26]. Erdogan et al [27] reported that the GLS values decreased considerably in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Demirelli¹,

Değirmenci²,

Ermis³

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants' ages ranged between 18 and 40 years. PCOS was diagnosed according to the Rotterdam criteria. LV strain (LS) and strain rate (SR) were evaluated using apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) imaging. Global LS and SR were calculated as average of three apical views. The waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and fasting insulin and triglyceride levels were higher in the PCOS group than in the controls (p = 0.001, p = 0.001, p = 0.001, and p = 0.005, respectively). In the PCOS group, the mitral A wave, deceleration time (DT), and isovolumetric relaxation time (IVRT) were significantly higher than in the controls (all p < 0.05). The LV global longitudinal strain (GLS) and global longitudinal SR systolic (GLSRS) were significantly lower in the PCOS patient group (both p = 0.001). There were strong negative correlations between GLS and both fasting insulin (r = −0.64) and DT (r = -0.62) (both p < 0.05). The study demonstrated that PCOS patients had decreased LV function using STE. Therefore, STE imaging appears to be useful for the early detection of subclinical LV dysfunction in patients with PCOS.

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“…Recently it has been used to detect myocardial dysfunction related to iron overload in patients with Beta-Thalassemia [66]. Basu et al .…”

Section: Cardiac Deformation Imaging Using Speckle Tracking Echocardimentioning

confidence: 99%

Advanced Echocardiographic Imaging of the Congenitally Malformed Heart

Black

Vettukattil²

2013

CCR

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There have been significant advancements in the ability of echocardiography to provide both morphological and functional information in children with congenitally malformed hearts. This progress has come through the development of improved technology such as matrix array probes and software which allows for the off line analysis of images to a high standard. This article focuses on these developments and discusses some newer concepts in advanced echocardiography such is multi-planar reformatting [MPR] and tissue motion annular displacement [TMAD].Our aim is to discuss important aspects related to the quality and reproducibility of data, to review the most recent published data regarding advanced echocardiography in the malformed heart and to guide the reader to appropriate text for overcoming the technical challenges of using these methods. Many of the technical aspects of image acquisition and post processing have been discussed in recent reviews by the authors and we would urge readers to study these texts to gain a greater understanding [1]. The quality of the two dimensional image is paramount in both strain analysis and three dimensional echocardiography. An awareness of how to improve image quality is vital to acquiring accurate and usable data.Three dimensional echocardiography (3DE) is an attempt to visualise the dynamic morphology of the heart. Although published media is the basis for theoretical knowledge of how to practically acquire images, electronic media [eg.] is the only way of visualising the advantages of this technology in real time.It is important to be aware of the limitations of this technology and that much of the data gleaned from using these methods is at a research stage and not yet in regular clinical practice.

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Myocardial Deformation in Patients with Beta‐Thalassemia Major: A Speckle Tracking Echocardiographic Study

Abstract: Patients with beta-thalassemia major have reduced longitudinal systolic SR, longitudinal early diastolic SR, and circumferential early diastolic SR. The rates of diastolic deformation in the longitudinal and circumferential dimensions are inversely related to myocardial iron overload.

Cited by 37 publications

References 40 publications

Role of Three‐Dimensional Speckle Tracking Echocardiography in the Quantification of Myocardial Iron Overload in Patients with Beta‐Thalassemia Major

Role of Three‐Dimensional Speckle Tracking Echocardiography in the Quantification of Myocardial Iron Overload in Patients with Beta‐Thalassemia Major

The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome

Advanced Echocardiographic Imaging of the Congenitally Malformed Heart

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