Myocardial Deformation in the Pediatric Age Group: Normal Values for Strain and Strain Rate Using <scp>2D</scp> Magnetic Resonance Feature Tracking

Voges, Inga; Negwer, Inken; Caliebe, Amke; Grazioli, Simona Boroni; Daubeney, Piers E.F.; Uebing, Anselm; Pennell, Dudley J.; Krupičková, Sylvia

doi:10.1002/jmri.28073

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Most children were of Caucasian ethnicity. Indications for MRI were described previously by our group 16 and included: 1) nondiagnostic echocardiographic examination, 2) uncertainty about the cardiac anatomy and myocardial structure on echocardiography, 3) syncope or 4) chest pain with low prescan probability of being cardiac in origin. MRI and clinical findings as well as clinical follow‐up did not show any evidence for a cardiovascular pathology.…”

Section: Methodsmentioning

confidence: 99%

Reference Values for Pediatric Atrial Volumes Assessed by Steady‐State Free‐Precession Magnetic Resonance Imaging Using Monoplane and Biplane Area‐Length Methods

Voges

Caliebe

Hinz

et al. 2022

Magnetic Resonance Imaging

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Background: Measurement of atrial volumes by MRI is becoming increasingly important in pediatric cardiac disorders. However, MRI normal values for atrial volumes in children are lacking. Purpose: To establish pediatric reference values for atrial volumes. Study Type: Retrospective. Subjects: A total of 155 healthy children from two large institutions (103 male, age 13.9 AE 2.8 years, range 4-18 years). Field Strength/Sequence: A 1.5 T; balanced steady-state free precession (bSSFP) sequence. Assessment: The monoplane and biplane area-length methods were used to measure minimal and maximal left and right atrial volumes (LA min , LA max , RA min , and RA max ) from four-chamber (4ch) and two-chamber (2ch) MR cine images. Centile charts and tables for atrial volumes were created. Statistical Tests: Descriptive statistics, lambda-mu-sigma (LMS)-method of Cole and Green, univariable and multivariable linear regression models. A P value < 0.05 was considered to be statistically significant. Results: In the multivariable linear model, body surface area was significantly associated with all atrial volumes and sex was significantly associated with RA volumes, LA volumes measured in the 2ch-view as well as biplane LA max. Average atrial volumes measured: monoplane 4ch: LA min 13.1 AE 4.8 mL/m 2 , LA max 33.4 AE 8.8 mL/m 2 , RA min 18.5 AE 6.8 mL/m 2 , RA max 33.2 AE 9.6 mL/m 2 ; monoplane 2ch: LA min 12.7 AE 4.9 mL/m 2 , LA max 30.5 AE 9.5 mL/m 2 ; biplane: LA min 12.3 AE 4.5 mL/m 2 , LA max 30.9 AE 8.7 mL/m 2 . Data Conclusion: Pediatric MRI reference values for atrial volumes have been provided. Technical Efficacy: 2 Evidence Level: 4

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Section: Methodsmentioning

confidence: 99%

Reference Values for Pediatric Atrial Volumes Assessed by Steady‐State Free‐Precession Magnetic Resonance Imaging Using Monoplane and Biplane Area‐Length Methods

Voges

Caliebe

Hinz

et al. 2022

Magnetic Resonance Imaging

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“…Deformation imaging has the potential as a tool to detect early/subclinical changes in LV function in a variety of congenital and acquired heart diseases (12)(13)(14)(15) and as a surrogate measure of outcome in therapeutic trials (16). However, there is limited data in the pediatric population particularly with AAOCA regarding utilization of this tool (14,17,18).…”

Section: Introductionmentioning

confidence: 99%

Wall motion assessment by feature tracking in pediatric patients with coronary anomalies undergoing dobutamine stress CMR

Sachdeva,

Molossi,

Reaves-O’Neal

et al. 2024

Front. Cardiovasc. Med.

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BackgroundLeft ventricular (LV) wall motion assessment is an important adjunct in addition to perfusion defects in assessing ischemic changes. This study aims to investigate the feasibility and utility of performing feature tracking (FT) in pediatric patients with coronary anomalies undergoing dobutamine stress CMR to assess wall motion abnormalities (WMA) and perfusion defects.MethodThis is a retrospective study where 10 patients with an inducible first-pass perfusion (FPP) defect and 10 without were selected. Global LV circumferential strain/strain rate (GCS/GCSR) was measured at rest and at peak stress (systole and diastole) using a commercially available feature tracking software. Peak GCS and GCSR were compared to indexed wall motion score (WMSI) between groups with and without FPP defect and in subjects with and without WMA.ResultsThe median age of patients was 13.5 years (Q1, 11 years; Q3, 15 years). Five subjects had qualitatively WMA at peak stress. A moderate correlation of GCS with WMSI at peak stress (0.48, p = 0.026) and a significant difference between GCS at rest and stress in patients with no inducible WMA (p = 0.007) were seen. No significant difference was noted in GCS between rest and stress in patients with WMA (p = 0.13). There was a larger absolute GCS/GCSR at peak stress in subjects with no inducible FPP defect or WMA.ConclusionSmaller absolute GCS and a lack of significant change in GCS at peak stress in those with inducible WMA or perfusion defect are suggestive of compromised LV deformation in subjects with inducible WMA. Given these findings, GCS derived from CMR-FT may be used to objectively assess WMA in pediatric patients undergoing stress CMR.

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Adolescent Reference Values for MR‐Derived Biventricular Strain Obtained Using Feature‐Tracking and Myocardial Tagging

Real,

Párraga,

González‐Calvo

et al. 2024

Magnetic Resonance Imaging

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BackgroundMyocardial strain is a promising marker for the detection of early left or right ventricular (LV or RV) dysfunction in pediatric populations. The reference standard for MR strain measurement is myocardial tagging (MT); however, MT has limited clinical utility because the additional acquisitions needed are time‐consuming. In contrast, MR‐feature tracking (FT) allows strain quantification from routinely acquired cine sequences. Studies providing reference values obtained with both FT and MT for adolescents are lacking.PurposeTo use MR‐FT and MT to define sex‐specific LV and RV strain reference values for adolescents.Study TypeCross‐sectional, prospective.PopulationOne hundred twenty‐three adolescents aged 15–18 years (52% girls) without known cardiovascular disease.Field Strength/SequenceBalanced steady‐state free‐precession sequence for FT analysis and a spatial modulation of magnetization hybrid TFE‐EPI sequence for MT acquisitions at 3.0‐T.AssessmentSegment Medviso software was used to obtain longitudinal (LS) and circumferential (CS) strain for both ventricles, and radial strain (RS) for LV.Statistical TestsThe Student t‐test was used for between‐sex comparisons of continuous variables. Sex‐specific percentiles were calculated using the weighted average method. Intraobserver and interobserver agreement was assessed in 30 randomly selected studies using intraclass correlation coefficients (ICC). A P‐value <0.05 was considered statistically significant.ResultsFT‐derived LVLS and LVCS were significantly higher in girls than in boys (−19.8% vs. −17.8% and −22.2% vs. −21.0%, respectively), as they were with MT (LVLS: −18.1% vs. −16.8%; LVCS: −20.8% vs. −19.7%). FT‐LVRS was higher in girls than in boys (44.8% vs. 35.1%), while MT‐LVRS was the opposite (18.6% vs. 22.7%). FT‐RVLS was higher in girls (−23.4% vs. −21.3%), but there were no between‐sex differences in MT‐derived RVLS or RVCS. ICC values for intraobserver agreement were ≥0.89, whereas for interobserver agreement were <0.80 for MT‐LVRS and ≥0.80 for all remaining parameters.Data ConclusionThis study provides sex‐specific reference biventricular strain values obtained with MR‐MT and MR‐FT for adolescents aged 15–18 years. MR‐FT may be a valid method for obtaining strain values in pediatric populations.Evidence Level1Technical EfficacyStage 3

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Myocardial Deformation in the Pediatric Age Group: Normal Values for Strain and Strain Rate Using 2D Magnetic Resonance Feature Tracking

Cited by 5 publications

References 33 publications

Reference Values for Pediatric Atrial Volumes Assessed by Steady‐State Free‐Precession Magnetic Resonance Imaging Using Monoplane and Biplane Area‐Length Methods

Reference Values for Pediatric Atrial Volumes Assessed by Steady‐State Free‐Precession Magnetic Resonance Imaging Using Monoplane and Biplane Area‐Length Methods

Wall motion assessment by feature tracking in pediatric patients with coronary anomalies undergoing dobutamine stress CMR

Adolescent Reference Values for MR‐Derived Biventricular Strain Obtained Using Feature‐Tracking and Myocardial Tagging

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