2024
DOI: 10.3390/jcm13071994
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Myocardial Expression of Pluripotency, Longevity, and Proinflammatory Genes in the Context of Hypercholesterolemia and Statin Treatment

Konstantinos S. Mylonas,
Michail Peroulis,
Emmanouil I. Kapetanakis
et al.

Abstract: Background: This study sought to assess the effect of statin therapy on myocardial inflammation in a White New Zealand rabbit model of atherogenesis. Methods: The mRNA expression levels of pro-inflammatory, pluripotency, and aging-related markers were quantified following a controlled feeding protocol and statin treatments. Results: Following high-cholesterol diet induction, we observed significant upregulation in the myocardial mRNA levels of MYD88, NF-κB, chemokines (CCL4, CCL20, and CCR2), IFN-γ, interleuki… Show more

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“…Klotho predominantly resides in renal distal convoluted tubules, parathyroid glands, and the choroid plexus. Recent findings also show its presence in vascular tissues and the myocardium [13,14,30,31], The gene for Klotho is found on chromosome 13q13.1, and it is responsible for producing a family of enzymes including α-Klotho, which is the most prevalent, as well as βand γ-Klotho [13].…”
Section: Klotho Structure and Functionmentioning
confidence: 99%
“…Klotho predominantly resides in renal distal convoluted tubules, parathyroid glands, and the choroid plexus. Recent findings also show its presence in vascular tissues and the myocardium [13,14,30,31], The gene for Klotho is found on chromosome 13q13.1, and it is responsible for producing a family of enzymes including α-Klotho, which is the most prevalent, as well as βand γ-Klotho [13].…”
Section: Klotho Structure and Functionmentioning
confidence: 99%