Myocardial flow reserve (MFR) with positron emission tomography (PET)/computed tomography (CT): clinical impact in diagnosis and prognosis

Ziadi, Maria C.

doi:10.21037/cdt.2017.04.10

Cited by 53 publications

(50 citation statements)

References 54 publications

(56 reference statements)

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“…Однако метод имеет ряд ограничений, связанных с полуколичественным характером оценки нарушений перфузии, когда за "норму" принимают область миокарда с максимальным накоплением перфузионного индикатора [3,4]. В отличие от ОФЭКТ, нагрузочная позитронная эмиссионная томография (ПЭТ), демонстрирует более высокую специфичность и точность за счет количественной оценки миокардиального кровотока (МК) и резерва миокардиального кровотока (РМК) в бассейне каждой артерии [5][6][7]. Однако техническая сложность, невысокая доступность и большие операционные расходы существенно ограничивают применение ПЭТ в реальной клинической практике.…”

Section: роль нагрузочной динамической однофотонной эмиссионной компьunclassified

Role of stress in dynamic single-photon emission computed tomography with myocardial perfusion reserve determination in assessing the severity of coronary artery stenosis

et al. 2019

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Aim. To assess the role of global and selected scintigraphic scores of myocardial perfusion, blood flow and reserve in the anatomical and functional significance of coronary artery (CA) stenosis.Material and methods. The double-blind comparative study included 23 patients (mean age 61,2±6,8 years, 12 (52%) women, 11 (48%) men). All patients underwent stress dynamic single-photon emission computed tomography (SPECT) with adenosine triphosphate (ATP) (140 µg/kg/min in 6 minutes). Myocardial perfusion disorders were assessed by a semi-quantitative method, the total Summed Stress Score (SSS), the Summed Rest Score (SRS), and the Summed Difference Score (SDS) were determined. Global (g) and regional (r) myocardial perfusion (MP) were evaluated; myocardial perfusion reserve (MPR) was calculated as the ratio of MP at stress and at rest. Coronary angiography (CAG) was performed within 1 week after SPECT, the amount of CA narrowing was evaluated by diameter. Stenoses >50% were considered anatomically significant. The assessment of the fractional flow reserve (FFR) was performed by the ratio of the mean intracoronary pressure at the CA ostia to the pressure distal to the stenosis at the ATP infusion peak. FFR ≤0,80 was considered a sign of hemodynamically significant stenosis. Results. Neither regional nor global scintigraphic scores reflecting myocardial perfusion showed statistical significance as markers of CA stenosis >50%. Among perfusion markers, only SSSg (>4) showed good sensitivity and specificity in the diagnosis of hemodynamically significant (FFR ≤0,80) stenoses (AUC 0,76; p=0,002; sensitivity 81,8%, specificity 83,3%). The following regional flow scores allowed identification of hemodynamically significant CA: stress MPr ≤0,54 ml/min/g (AUC 0,8; p=0,0003; sensitivity 57%, specificity 92%) and MPR ≤1,5 (AUC 0,86; p< 0,0001; sensitivity 71,4%, specificity 92,8%).Conclusion. It is proved that global and regional scintigraphic scores of MP and MPR are sensitive and specific markers of hemodynamically significant (FFR ≤0,80) coronary stenosis. It can be more useful for localization diagnosis of the lesion than standard SPECT.

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Section: роль нагрузочной динамической однофотонной эмиссионной компьunclassified

Role of stress in dynamic single-photon emission computed tomography with myocardial perfusion reserve determination in assessing the severity of coronary artery stenosis

et al. 2019

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“… 1 , 3 The combination of MPI PET/CT with MBF quantification can further improve risk and treatment stratification, disease detection, and the ability to monitor lifestyle modifications or therapeutic interventions. 1 , 3 , 4 The capability to routinely and non-invasively quantify MBF in mL/min/gram is unique to PET/CT. 4 …”

Section: Introductionmentioning

confidence: 99%

“… 1 , 3 , 4 The capability to routinely and non-invasively quantify MBF in mL/min/gram is unique to PET/CT. 4 …”

Section: Introductionmentioning

confidence: 99%

The continual innovation of commercial PET/CT solutions in nuclear cardiology: Siemens Healthineers

Bendriem

Reed

McCullough

et al. 2018

Journal of Nuclear Cardiology

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Cardiac PET/CT is an evolving, non-invasive imaging modality that impacts patient management in many clinical scenarios. Beyond offering the capability to assess myocardial perfusion, inflammatory cardiac pathologies, and myocardial viability, cardiac PET/CT also allows for the non-invasive quantitative assessment of myocardial blood flow (MBF) and myocardial flow reserve (MFR). Recognizing the need for an enhanced comprehension of coronary physiology, Siemens Healthineers implemented a sophisticated solution for the calculation of MBF and MFR in 2009. As a result, each aspect of their innovative scanner and image-processing technology seamlessly integrates into an efficient, easy-to-use workflow for everyday clinical use that maximizes the number of patients who potentially benefit from this imaging modality.Electronic supplementary materialThe online version of this article (10.1007/s12350-018-1262-3) contains supplementary material, which is available to authorized users.

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“…[5][6][7][8] However, its diffuse application in the clinical scenario is limited by the technical complexity and elevated operative costs. 9 Previous studies investigated the feasibility of MFR quantification using dynamic scintigraphy and 99m Tc tracers in humans. [10][11][12][13][14] Nevertheless, the dynamic collection of tomographic data, necessary to obtain MBF and MFR accurate measurements, is limited using conventional SPECT systems.…”

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confidence: 99%

Myocardial perfusion reserve by using CZT: It’s a long way to the top if you wanna standardize

Zampella

Assante

Gaudieri

et al. 2021

Journal of Nuclear Cardiology

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Myocardial flow reserve (MFR) with positron emission tomography (PET)/computed tomography (CT): clinical impact in diagnosis and prognosis

Cited by 53 publications

References 54 publications

Role of stress in dynamic single-photon emission computed tomography with myocardial perfusion reserve determination in assessing the severity of coronary artery stenosis

Role of stress in dynamic single-photon emission computed tomography with myocardial perfusion reserve determination in assessing the severity of coronary artery stenosis

The continual innovation of commercial PET/CT solutions in nuclear cardiology: Siemens Healthineers

Myocardial perfusion reserve by using CZT: It’s a long way to the top if you wanna standardize

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