Myocardial <i>meta</i>-[<sup>125</sup>I]iodobenzylguanidine uptake in awake genetically hypertensive rats at different ages: an autoradiographic study

Schwebel, Carole; Durand, Andrée; Godin‐Ribuot, Diane; Provendier, O; Demenge, Pierre

doi:10.1139/y99-033

Cited by 3 publications

(2 citation statements)

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“…The result indicated that the hypertrophied heart in SHRs becomes heavier during the progression of LVH, which is in accordance with that reported by other authors. 3,45 In summary, we found that the earliest stage when dynamic SPECT with 123 I-MIBG can detect an abnormality in the LV of SHRs is at 6 months. Dynamic SPECT with 201 Tl can detect perfusion abnormalities in the LV of SHRs at 18 months.…”

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confidence: 61%

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Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography

et al. 2015

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The objective of this work was to evaluate the sympathetic nervous system and structure remodeling during the progression of heart failure in a rodent model using dynamic cardiac single-photon emission computed tomography (SPECT). The spontaneously hypertensive rat (SHR) model was used to study changes in the nervous system innervation and perfusion in the left ventricular (LV) myocardium with the progression of left ventricular hypertrophy (LVH) to heart failure. Longitudinal dynamic SPECT studies were performed with seven SHR and seven Wistar-Kyoto (WKY) rats over 1.5 years using a dual-head SPECT scanner with pinhole collimators. Time-activity curves (TACs) of the 123I-MIBG and 201Tl distribution in the LV blood pool and myocardium were extracted from dynamic SPECT data and fitted to compartment models to determine the influx rate, washout rate, and distribution volume (DV) of 123I-MIBG and 201Tl in the LV myocardium. The standardized uptake values (SUVs) of 123I-MIBG and 201Tl in the LV myocardium were also calculated from the static reconstructed images. The influx and washout rates of 123I-MIBG did not show a significant difference between SHRs and WKY rats. The DVs of 123I-MIBG were greater in the SHRs than in the WKY rats (p = .0028). Specifically, the DV of 123I-MIBG became greater in the SHRs by 6 months of age (p = .0017) and was still significant at the age of 22 months. The SUV of 123I-MIBG in SHRs exhibited abnormal values compared to WKY rats from the age of 18 months. There was no difference in the influx rate and the washout rate of 201Tl between the SHRs and WKY rats. The SHRs exhibited greater DV of 201Tl than WKY rats after the age of 18 months (p = .034). The SUV of 201Tl in SHRs did not show any significant difference from WKY at all ages. The higher DV of 123I-MIBG in the LV myocardium reveals abnormal nervous system activity of the SHRs at an age of 6 months, whereas a greater DV of 201Tl in the LV myocardium can only be detected at an age of 18 months. The results show that the abnormal nervous system activity appears earlier than perfusion. Furthermore, the comparison between the DV and the SUV indicates that dynamic SPECT with 123I-MIBG and 201Tl with the kinetic parameter DV is capable of detecting abnormalities of the LV at an early age.

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confidence: 61%

“…The result indicated that the hypertrophied heart in SHRs becomes heavier during the progression of LVH, which is in accordance with that reported by other authors. 3,45…”

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confidence: 99%

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography

et al. 2015

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Preclinical Evaluations of Cardiac Sympathetic Innervation Radiotracers

Raffel

2014

Autonomic Innervation of the Heart

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Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

et al. 2019

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The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of sympathetic nerves projecting to the heart has been observed in several cardiovascular diseases, and sympathetic dysfunction contributes to cardiac pathology. Wistar Kyoto rats are a common model for the study of cardiovascular diseases, but we lack a profile of the baseline transcriptomic and neurochemical characteristics of their cardiac sympathetic neurons. Most studies of cardiovascular disease have used male animals only, but in the future both male and female animals will be used for these types of studies; therefore, we sought to characterize the transcriptome of male and female stellate ganglia and to correlate that with catecholamine and acetylcholine content in the heart. We have generated a dataset of baseline RNA expression in male and female Wistar Kyoto rat stellate ganglia using RNA-seq, and have measured neurotransmitter levels in heart and stellate ganglia using HPLC and mass spectrometry. We identified numerous gene expression differences between male and female stellates, including genes encoding important developmental factors, receptors and neuropeptides. Female hearts had significantly higher neurotransmitter content than male hearts; however, no significant differences were detected in expression of the genes encoding neurotransmitter synthetic enzymes. Similarly, no statistically significant differences were identified between the sexes in cardiac tyrosine hydroxylase levels.

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Myocardial meta-[¹²⁵I]iodobenzylguanidine uptake in awake genetically hypertensive rats at different ages: an autoradiographic study

Cited by 3 publications

References 21 publications

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography

Preclinical Evaluations of Cardiac Sympathetic Innervation Radiotracers

Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

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Myocardial meta-[125I]iodobenzylguanidine uptake in awake genetically hypertensive rats at different ages: an autoradiographic study

Cited by 3 publications

References 21 publications

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography

Preclinical Evaluations of Cardiac Sympathetic Innervation Radiotracers

Sex differences in sympathetic gene expression and cardiac neurochemistry in Wistar Kyoto rats

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Product

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Myocardial meta-[¹²⁵I]iodobenzylguanidine uptake in awake genetically hypertensive rats at different ages: an autoradiographic study